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Journal of Neuro-Oncology

, Volume 47, Issue 3, pp 189–194 | Cite as

Surgical Pathology of Intramedullary Spinal Cord Neoplasms

  • Douglas C. Miller
Article

Abstract

The surgical pathology of intramedullary spinal cord neoplasms is most accurately based on radical resection specimens rather than on small biopsies, which may be highly misleading. A review of the neuropathology files at NYU Medical Center revealed 294 surgical specimens of intramedullary cord lesions examined between January 1, 1991 and December 31, 1998. Of these 117 were from children (age less than 21 years) and 177 were from adults (21 and over). While most types of central nervous system tumors known to occur in the brain also occur in the spinal cord, the different proportions of these tumors by histologic type, and the differences in the proportions of tumor types in children compared to adults, are both significant. In adults ependymomas are the predominant tumor type (93 total) while in children astrocytomas and mixed neuronal-glial tumors are virtually equally common and outnumber ependymomas. In this period no cord Primitive Neuroectodermal Tumors were identified. Among the astrocytic neoplasms and other gliomas, high grade tumors were distinctly uncommon in children and only slightly more common in adults, in sharp contrast with the brain, where the majority of adult intra-axial tumors are high grade.

spinal cord intramedullary neoplasms pathology astrocytoma ependymoma ganglioglioma 

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Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Douglas C. Miller
    • 1
  1. 1.Departments of Pathology (Division of Neuropathology) and NeurosurgeryNew York University School of Medicine, and the Kaplan Comprehensive Cancer Center of NYUNew YorkUSA

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