Plant Molecular Biology

, Volume 43, Issue 5–6, pp 643–657

Regulation of histone gene expression during the cell cycle

  • Tetsuo Meshi
  • Ken-ichiro Taoka
  • Masaki Iwabuchi

DOI: 10.1023/A:1006421821964

Cite this article as:
Meshi, T., Taoka, K. & Iwabuchi, M. Plant Mol Biol (2000) 43: 643. doi:10.1023/A:1006421821964


The steady-state level of histone mRNAs fluctuates coordinately with chromosomal DNA synthesis during the cell cycle. Such an S phase-specific expression pattern results from transcriptional activation of histone genes coupled with the onset of replication and from transcriptional repression of the genes as well as specific destabilization of histone mRNAs around the end of the S phase. Proliferation-coupled and S phase-specific expression of histone genes is primarily achieved by the activities of the proximal promoter regions, where several conserved cis-acting elements have been identified. Among them, three kinds of Oct-containing composite elements (OCEs) play a pivotal role in S phase-specific transcriptional activation. Other ones, such as Nona, solo-Oct, and CCGTC motifs, appear to modulate the functions of OCEs to enhance or repress the transcriptional level, possibly depending on the state of the cells. Here, we review the growing evidence concerning the regulatory mechanisms by which plant histone genes are expressed S phase-specifically in proliferating cells.

cell cycle gene regulation histone proliferation S phase-specific expression 


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Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Tetsuo Meshi
    • 1
  • Ken-ichiro Taoka
    • 2
  • Masaki Iwabuchi
    • 3
  1. 1.Department of Botany, Graduate School of ScienceKyoto University, Sakyo-kuKyotoJapan
  2. 2.Graduate School of Biological SciencesNara Institute of Science and TechnologyIkomaJapan
  3. 3.Research Institute for Biological Sciences (RIBS)OkayamaJapan

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