Journal of Neuro-Oncology

, Volume 48, Issue 1, pp 27–40 | Cite as

Tolerance of the Normal Canine Brain to Epithermal Neutron Irradiation in the Presence of p-boronophenylalanine

  • Jeffrey A. Coderre
  • Patrick R. Gavin
  • Jacek Capala
  • Ruimei Ma
  • Gerard M. Morris
  • Terry M. Button
  • Tariq Aziz
  • Nancy S. Peress


Twelve normal dogs underwent brain irradiation in a mixed-radiation, mainly epithermal neutron field at the Brookhaven Medical Research Reactor following intravenous infusion of 950 mg of 10B-enriched BPA/kg as its fructose complex. The 5 × 10 cm irradiation aperture was centered over the left hemisphere. For a subgroup of dogs reported previously, we now present more detailed analyses including dose–volume relationships, longer follow-ups, MRIs, and histopathological observations. Peak doses (delivered to 1 cm3 of brain at the depth of maximum thermal neutron flux) ranged from 7.6 Gy (photon-equivalent dose: 11.8 Gy-Eq) to 11.6 Gy (17.5 Gy-Eq). The average dose to the brain ranged from 3.0 Gy (4.5 Gy-Eq) to 8.1 Gy (11.9 Gy-Eq) and to the left hemisphere, 6.6 Gy (10.1 Gy-Eq) to 10.0 Gy (15.0 Gy-Eq). Maximum tolerated ‘threshold’ doses were 6.7 Gy (9.8 Gy-Eq) to the whole brain and 8.2 Gy (12.3 Gy-Eq) to one hemisphere. The threshold peak brain dose was 9.5 Gy (14.3 Gy-Eq). At doses below threshold, some dogs developed subclinical MRI changes. Above threshold, all dogs developed dose-dependent MRI changes, neurological deficits, and focal brain necrosis.

boron neutron capture therapy boronophenylalanine BNCT brain epithermal neutrons irradiation normal tissue tolerance 


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Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Jeffrey A. Coderre
    • 1
  • Patrick R. Gavin
    • 2
  • Jacek Capala
    • 1
  • Ruimei Ma
    • 1
  • Gerard M. Morris
    • 3
  • Terry M. Button
    • 4
  • Tariq Aziz
    • 5
  • Nancy S. Peress
    • 5
  1. 1.Medical DepartmentBrookhaven National LaboratoryUptonUSA
  2. 2.Veterinary Clinical SciencesWashington State UniversityPullmanUSA
  3. 3.Research InstituteUniversity of Oxford, Churchill HospitalOxfordUK
  4. 4.Department of Radiology, Neuropathology Division, School of MedicineState University of New York at Stony BrookStony BrookUSA
  5. 5.Department of Pathology, Neuropathology Division, School of MedicineState University of New York at Stony BrookStony BrookUSA

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