Journal of Neuro-Oncology

, Volume 49, Issue 1, pp 1–7

Progesterone Receptor Isoforms Expression Pattern in Human Chordomas

  • Ignacio Camacho-Arroyo
  • Gabriela González-Agüero
  • Armando Gamboa-Domínguez
  • Marco A. Cerbón
  • Rodolfo Ondarza
Article

DOI: 10.1023/A:1006412000726

Cite this article as:
Camacho-Arroyo, I., González-Agüero, G., Gamboa-Domínguez, A. et al. J Neurooncol (2000) 49: 1. doi:10.1023/A:1006412000726

Abstract

Steroid hormone receptors are involved in the regulation of tumor growth. Two progesterone receptor (PR) isoforms have been identified in humans: a larger form (PR-B) and the N-terminally truncated one (PR-A). PR isoforms can exert opposite functions and are differentially regulated by estrogens. PR have been detected in several brain tumors including chordomas, however, it is unknown which PR isoform is expressed in brain tumors. The aim of this study was to determine by reverse transcription-polymerase chain reaction (RT-PCR) and by immunohistochemistry the expression pattern of PR isoforms in chordomas as well as its correlation with the expression of estrogen receptor α (ER-α). All studied chordomas expressed both PR and ER-α. PR-B was the predominant isoform in chordomas both at the mRNA and at the protein level. These data suggest that PR-B should be the predominant PR isoform expressed in human chordomas.

chordoma progesterone receptors estrogen receptors 

Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Ignacio Camacho-Arroyo
    • 1
  • Gabriela González-Agüero
    • 1
  • Armando Gamboa-Domínguez
    • 2
  • Marco A. Cerbón
    • 1
  • Rodolfo Ondarza
    • 3
  1. 1.Departamento de Biología, Facultad de QuímicaUniversidad Nacional Autónoma de MéxicoMexico
  2. 2.Departamento de PatologíaInstituto Nacional de la NutriciónMexico CityMéxico
  3. 3.Departamento de NeurocirugíaInstituto Nacional de Neurología y NeurocirugíaMexico CityMéxico

Personalised recommendations