Veterinary Research Communications

, Volume 23, Issue 6, pp 361–368 | Cite as

Modification of the Pharmacokinetics and Dosage of Cefuroxime by Endotoxin-induced Fever in Buffalo Calves

  • R.K. Chaudhary
  • A.K. Srivastava
  • S. Rampal
Article

Abstract

The effect of endotoxin-induced fever on the pharmacokinetics and dosage regimen of cefuroxime was investigated in buffalo calves following a single intravenous dose of 10 mg/kg body weight. The fever was induced by intravenous administration of E. coli endotoxin at a dose of 1 μg/kg body weight. The distribution and elimination half-lives were 0.100 h and 1.82 h, respectively, in healthy and 0.109 h and 2.28 h, respectively, in febrile buffalo calves. About 91% of the administered dose was excreted in the urine within 24 h. There was no effect of fever on the plasma protein binding of cefuroxime. The dosage regimen for intravenous administration of cefuroxime may be reduced in febrile conditions but the probability of this was only 0.3.

buffalo cefuroxime dosage endotoxin excretion fever pharmacokinetics plasma urine 

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REFERENCES

  1. Ahmad, A.H., Bahga, H.S. and Sharma, L.D., 1994. Pharmacokinetics of gentamicin following single dose intravenous administration in normal and febrile goats. Journal of Veterinary Pharmacology and Therapeutics, 17, 369–373Google Scholar
  2. Arret, B., Johnson, D.P. and Krishbaum, A., 1971. Outline of details of microbiological assay of antibiotics. Journal of Pharmaceutical Sciences, 60, 1689–1694Google Scholar
  3. Bundtzen, R.W., Toothaker, R.D., Nielson, O.S., Madsen, P.O., Welling, P.G. and Craig, W.A., 1981. Pharmacokinetics of cefuroxime in normal and impaired renal function: comparison of high pressure liquid chromatography and microbiological assays. Antimicrobial Agents and Chemotherapy, 19, 443–449Google Scholar
  4. Burrows, G.E., 1985. Effect of experimentally induced P. haemolytica pneumonia on the pharmacokinetics of erythromycin in calf. American Journal of Veterinary Research, 46, 798–803Google Scholar
  5. Foord, R.D., 1976. Cefuroxime: human pharmacokinetics. Antimicrobial Agents and Chemotherapy, 9, 741–747Google Scholar
  6. Frazier, D.L., Aucoin, D.P. and Riviere, J.E., 1988. Gentamicin pharmacokinetics and nephrotoxicity in naturally acquired and experimentally induced disease in dog. Journal of American Veterinary Medical Association, 192, 57–63Google Scholar
  7. Gibaldi, M. and Perrier, D., 1982. Appendix C: method of residuals. Pharmacokinetics (Marcel Dekker, New York), 433–444Google Scholar
  8. Kunin, C.M., Dornbush, A.C. and Finland, M., 1959. Distribution and excretion of four tetracycline analogues in normal young men. Journal of Clinical Investigations, 38, 1950–1963Google Scholar
  9. Lohuis, J.A.C.M., Verheijden, J.H.M., Burvenich, C. and Van Miert, A.S.J.P.A.M., 1988. Pathophysiolo-gical effects of endotoxin in ruminants. Veterinary Quarterly, 10, 109–125Google Scholar
  10. Mandell, G.L., 1979. The cephalosporins. In: G.L. Mandell, R.G. Douglas Jr and J.E. Bernelt (eds), Principles and Practices of Infectious Diseases, (Wiley, New York), 238–248Google Scholar
  11. Mandell, G.L. and Sande, M.A., 1991. Penicillins, cephalosporins and other beta-lactam antibiotics. In: A.G. Gilman, T.W. Rall, A.S. Nies and P. Taylor (eds), Goodman and Gilman's The Pharmacological Basis of Therapeutics, (Maxwell Macmillan, Singapore), 1065–1097Google Scholar
  12. O'Callaghan, C.H., Sykes, R.B., Ryan, D.M., Foord, R.D. and Muggleton, P.W., 1976. Cefuroxime-a new cephalosporin antibiotic. Journal of Antibiotics, 29, 29–37Google Scholar
  13. Pennington, J.E., Dale, D.C., Regnolds, H.Y. and Haclowry, J.D., 1975. Gentamicin sulphate pharmaco-kinetics lower levels of gentamicin in blood during fever. Journal of Infectious Diseases, 132, 270–275Google Scholar
  14. Pilload, M., 1973. Pharmacokinetics, plasma protein binding and dosage regimen of oxytetracycline in cattle and horses. Research in Veterinary Science, 15, 224–230Google Scholar
  15. Snedecor, G.W. and Cochran,W.G., 1967. Statistical Methods (Oxford and IBH, Calcutta), 37–52Google Scholar
  16. Soback, S., Ziv, G. and Kokhe, E.I., 1989. Probenecid e¡ect on cefuroxime pharmacokinetics in calves. Journal of Veterinary Pharmacology and Therapeutics, 12, 87–93Google Scholar
  17. Van Miert, A.S.J.P.A.M., 1987. Fever, anorexia and forestomach hypomobility in ruminants. Veterinary Research Communications, 11, 407–422Google Scholar

Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • R.K. Chaudhary
    • 1
  • A.K. Srivastava
    • 1
  • S. Rampal
    • 1
  1. 1.Department of Pharmacology and Toxicology, College of Veterinary SciencePunjab Agricultural UniversityLudhianaIndia

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