Veterinary Research Communications

, Volume 23, Issue 6, pp 361–368 | Cite as

Modification of the Pharmacokinetics and Dosage of Cefuroxime by Endotoxin-induced Fever in Buffalo Calves

  • R.K. Chaudhary
  • A.K. Srivastava
  • S. Rampal


The effect of endotoxin-induced fever on the pharmacokinetics and dosage regimen of cefuroxime was investigated in buffalo calves following a single intravenous dose of 10 mg/kg body weight. The fever was induced by intravenous administration of E. coli endotoxin at a dose of 1 μg/kg body weight. The distribution and elimination half-lives were 0.100 h and 1.82 h, respectively, in healthy and 0.109 h and 2.28 h, respectively, in febrile buffalo calves. About 91% of the administered dose was excreted in the urine within 24 h. There was no effect of fever on the plasma protein binding of cefuroxime. The dosage regimen for intravenous administration of cefuroxime may be reduced in febrile conditions but the probability of this was only 0.3.

buffalo cefuroxime dosage endotoxin excretion fever pharmacokinetics plasma urine 


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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • R.K. Chaudhary
    • 1
  • A.K. Srivastava
    • 1
  • S. Rampal
    • 1
  1. 1.Department of Pharmacology and Toxicology, College of Veterinary SciencePunjab Agricultural UniversityLudhianaIndia

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