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Journal of Neuro-Oncology

, Volume 44, Issue 2, pp 137–145 | Cite as

Phase II Studies of RMP-7 and Carboplatin in the Treatment of Recurrent High Grade Glioma

  • A. Gregor
  • M. Lind
  • H. Newman
  • R. Grant
  • D.M. Hadley
  • T. Barton
  • C. Osborn
Article

Abstract

The selective bradykinin analogue, RMP-7, transiently increases the permeability of the blood brain barrier and the delivery of hydrophilic agents into brain tumours. In 87 recurrent glioma patients (WHO Grade III/IV, median age 46, Karnofsky 70%) clinical and Magnetic Resonance Imaging (MRI) responses to i.v. cycles (q 28 days) of RMP-7 (300 ng/kg given as a 10 min infusion) and carboplatin (AUC 4-9) were assessed. 45 of these patients were chemotherapy naive (CN-RMP) and 42 had received one prior course of chemotherapy (CP-RMP). Neurological impairment, performance status and steroid use were measured prior to dosing at each cycle and tumour volume by 3-D MRI at the end of cycles 2, 4, 6, 9 and 12. Clinical evaluation of response demonstrated that 61% of CN-RMP patients were either stable or improved whilst this was 39% for CP-RMP patients, of which 37% and 8% improved respectively. Radiological evaluation showed 79% of CN-RMP patients were either stable, partial or complete responses and 24% for CP-RMP patients, of which 32% and 5% were CR or PR respectively.

The median duration of response was 30.3 weeks in CN-RMP patients and 19.6 weeks in the CP-RMP group. Lack of response was associated with substantial baseline tumour volume. Drug toxicity was as previously reported for carboplatin. 11 patients had treatment-associated transient focal seizures. These results indicate that RMP-7 and carboplatin have significant activity in recurrent malignant glioma following radiotherapy.

glioma RMP-7 carboplatin 

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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • A. Gregor
    • 1
  • M. Lind
    • 2
  • H. Newman
    • 3
  • R. Grant
    • 1
  • D.M. Hadley
    • 4
  • T. Barton
    • 5
  • C. Osborn
    • 5
  1. 1.Department of Clinical OncologyUniversity of Edinburgh, Western General HospitalEdinburghUK
  2. 2.Department of Clinical Oncology, Northern Centre for Cancer Treatment, Newcastle General HospitalUniversity of Newcastle upon TyneNewcastle upon TyneUK
  3. 3.Department of Clinical OncologyBristol Oncology CentreBristolUK
  4. 4.Department of NeuroradiologyInstitute of Neurological SciencesGlasgowUK
  5. 5.Alkermes Europe Ltd, The QuorumCambridgeUK

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