Journal of Neuro-Oncology

, Volume 45, Issue 3, pp 237–240 | Cite as

Choroid Plexus Metastasis from Carcinoma of the Bladder: Case Report and Review of the Literature

  • Raed Qasho
  • Vangelista Tommaso
  • Giovanni Rocchi
  • Umberto Simi
  • Roberto Delfini


We present here a case report of a 40-year old male with adenocarcinoma of the bladder and solitary metastasis to the choroid plexus of the right lateral ventricle. This is the first such report of such a metastasis in association with bladder carcinoma. Systemic metastases frequently occur in patients with carcinoma of the bladder but involvement of central nervous system is relatively uncommon: less than 1% of patients with carcinoma of the bladder present an intracerebral metastasis. In the majority of cases there are either multiple CNS metastases or other distant metastases. A few cases present with solitary metastases to the CNS without evidence of recurrent or disseminated disease.

bladder carcinoma metastasis central nervous system 


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  1. 1.
    Babaian RJ, Johnson RJ, Lamas L, Ayala AG: Metastases from transitional cell carcinoma of urinary bladder. Urology 16: 142–144, 1980PubMedGoogle Scholar
  2. 2.
    Fetter TR, Bogalev JH, McCuskey B, Seres JL: Carcinoma of the bladder: Sites of metastases. J Urol 81: 746–748, 1959PubMedGoogle Scholar
  3. 3.
    Goldman SM, Fajardo AA, Naraval RC, Madewell JE: Metastatic transitional cell cancer of the bladder: Radiographic manifestations. AJR 132: 419–425, 1979PubMedGoogle Scholar
  4. 4.
    Hust MH, Pfitzer P: Cerebrospinal fluid and metastases of transitional cell carcinoma of the bladder. Acta Cytol 26: 217, 1982PubMedGoogle Scholar
  5. 5.
    LeadbetterWF, Colston JAC: Brain metastases in carcinoma of the bladder. J Urol 38: 267–277, 1937Google Scholar
  6. 6.
    Paillas JE, PelletW: Brain metastases. In: Vinken PJ, Bruyn GW (eds) Handbook of Clinical Neurology Vol. 18, American Elsevier Publishing Co, Inc., New York, pp. 201–232Google Scholar
  7. 7.
    Stortebecker JP: Metastatic tumor of the brain from a neurological point of view: A follow-up study of 158 cases. J Neurosurg 11: 84–111, 1954PubMedGoogle Scholar
  8. 8.
    Vinchon M, Ruchoux MM, Sueur JP, Assaker R, Chirstiaens JL: Solitary brain metastasis as only recurrence of a carcinoma of the bladder. Clin Neuropathol 13(6): 338–340, 1994PubMedGoogle Scholar
  9. 9.
    Whitmore WF Jr, Batata MA, Ghoneim MA, Grabstald H, Unal A: Radical cystectomy with or without prior irradiation in the treatment of bladder cancer. J Urol 118: 184, 1977PubMedGoogle Scholar
  10. 10.
    Baker AB: Metastatic tumors of the nervous system. Arch Pathol 34: 495–537, 1942Google Scholar
  11. 11.
    Walther HE: Krebsmetastaten. Benno Schwabe & Co Verlag, Basel, 1948, p. 485Google Scholar
  12. 12.
    Murphy GP: The current status of bladder cancer. Surg Annu 7: 175–218, 1975PubMedGoogle Scholar
  13. 13.
    Murphy P, Alexander P, Kirkham N, Fleming J, Taylor I: Pattern of spread of bloodborne tumour. Br J Surg, 73 Oct: 829–834, 1986PubMedGoogle Scholar
  14. 14.
    Shamads GJ, MacLaren GD, Grimm T, Everson LK: Solitary cerebellar metastasis from transitional cell carcinoma of bladder. Urology 40: 50–53, 1992PubMedGoogle Scholar
  15. 15.
    Carincross JG, Posner JB: The management of brain metastase. In:Walker MD (ed) Oncology of the Nervous System. Martinus nijhoff Publishers, Hingham, Mass., 1983, pp 341–378Google Scholar
  16. 16.
    Baston OV: The vertebralvein system. Am J Rontgenol 78: 195–212, 1957Google Scholar
  17. 17.
    Baston OV: The function of the vertebral veins and their role in the spread of metastases. Ann Surg 112: 138, 1940Google Scholar
  18. 18.
    Moanz comment to Davisi's. Isolated central nervous system metastasis from transitional cell carcinoma of the bladder: Report of a case and review of the literature. Neurosurgery 18: 622–624, 1986Google Scholar
  19. 19.
    Lower WE, Watkins RM: A case of primary carcinoma of the bladder with metastasis to the brain. Am J Med Sci 167: 434–437, 1924Google Scholar
  20. 20.
    Fujiwara S, Takak T, Hikita T, Kanazaki H, Kuroiwa S: Brain metastasis from urachal carcinoma. Surg Neurol 29: 475–476, 1988PubMedGoogle Scholar
  21. 21.
    Scott AR, El-Mahdi A, Kuban D, Higgins EM: Brain metastases from transitional cell carcinoma of urinary bladder. Urology 39: 17–20, 1992PubMedGoogle Scholar
  22. 22.
    Sheldon CA, Clayman RV, Gonzalez R, Williams RD, Fraley EE: Malignant urachal lesions. J Urol 131: 1–8, 1984PubMedGoogle Scholar
  23. 23.
    Tewari MK, Virinder K Khosla, Sharma BS, Rakesh K, Vashistha, Path MR, Khandelwal, Dip MD and VijayKKak: Brain Metastasis from urachal carcinoma: Case report. Surg Neurol 42: 340–342, 1994PubMedGoogle Scholar
  24. 24.
    Ross JA, Newall J: Unusual metastases in bladder carcinoma. J R Coll Surg Edinb 6: 51–58, 1961Google Scholar
  25. 25.
    Kabalin JN, Freiha FS, Torti FM: Brain metastases from transitional cell carcinoma of the bladder. J Urol 140: 820, 1988PubMedGoogle Scholar
  26. 26.
    Kart BH, Reddy SC, Rao GR, Poveda H: Choroid plexus metastasis. CT appearance. J Comput Assist Tomogr 10: 537–540, 1986PubMedGoogle Scholar
  27. 27.
    Kendall B, Reider-Grosswasser I, Valentine A: Diagnosis of masses presenting within the ventricles on computed tomography. Neuroradiology 25: 11–22, 1983PubMedGoogle Scholar
  28. 28.
    Lewis P: Carcinoma of the choroid plexus. Brain 90(1): 177–186, 1967PubMedGoogle Scholar
  29. 29.
    Mizuno M, Asakura K, Nakajima S, Sampei T, Sayama I, Kawamura S, Yasui S, Fukazawa H: Renal cell carcinoma metastasizing to choroid plexus of lateral ventricle: A case report. No-Shinkei-Geka (Tokyo) 20: 469–474, 1992Google Scholar
  30. 30.
    Michihiro Kohno, Masao Matsutani, Tomio Sasaki, Kintomo Takura. Solitary metastasis to the choroid plexus of the lateral ventricle. J Neuro-Oncol. 27: 47–52, 1996Google Scholar
  31. 31.
    Nakabayashi H, Murata K, Sakaguchi S, Nakajima K, Katsuyama J: Choroid plexus metastasis from gastric cancer. Case report. Neurol Med Chir (Tokyo) 34: 183–186, 1994Google Scholar
  32. 32.
    Suetake K, Shinya T, Takeda M:Achoroid plexus metastasis of a renal cell carcinoma: a case report. Jpn J Neurosurg (Tokyo) 3: 436–441, 1994Google Scholar
  33. 33.
    Tanimoto M, Tatasumi S, Tominaga S, Kamikawa S, Nagao T, Tamaki N, Matsumoto S: Choroid plexus metastasis of lung carcinoma. Case report. Neurol Med Chir (Tokyo) 3l: 152–155, 1991Google Scholar
  34. 34.
    Shigemori M, Shimamoto H, Noguchi S, Yoshitake Y, Sugita Y, Kuramoto S: Choroid plexus metastasis of renalcell carcinoma. CT Kenkyu (Japan) 9: 603–606, 1987Google Scholar

Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Raed Qasho
    • 1
  • Vangelista Tommaso
    • 1
  • Giovanni Rocchi
    • 1
  • Umberto Simi
    • 2
  • Roberto Delfini
    • 1
  1. 1.Department of Neurological Sciences, Neurosurgery, ‘La Sapienza’University of RomeItaly
  2. 2.A.S.L.H. 6LivorhoItaly

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