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Journal of Neuro-Oncology

, Volume 44, Issue 3, pp 223–231 | Cite as

Effects of Radiation on a Model of Malignant Glioma Invasion

  • Glenn S. Bauman
  • Warren MacDonald
  • Emi Moore
  • David A. Ramsey
  • Barbara J. Fisher
  • Verena R. Amberger
  • Rolando M. Del Maestro
Article

Abstract

We sought to characterize the effects of radiation alone and in combination with BCNU and dexamethasone on malignant glioma invasion. A model of malignant glioma invasion into a gel matrix of collagen type I was used to characterize response to radiation treatment for four malignant glioma cell lines (C6, U251, U373, A172) and nine primary human glioblastoma explants. A radiation dose dependent inhibition of invasion was noted for the C6 astrocytoma cell line but not the other cell lines or explants. Addition of BCNU and dexamethasone to radiation produced additional inhibition of invasion among the cell lines and explants but could not suppress invasion entirely.

glioma invasion radiation 

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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Glenn S. Bauman
    • 1
  • Warren MacDonald
    • 2
  • Emi Moore
    • 2
    • 5
  • David A. Ramsey
    • 3
  • Barbara J. Fisher
    • 1
  • Verena R. Amberger
    • 2
  • Rolando M. Del Maestro
    • 4
    • 2
  1. 1.Department of Radiation Oncology, London Regional Cancer Clinic and Department of OncologyUniversity of Western OntarioCanada
  2. 2.Brain Research Laboratory, Experimental Research Unit, Division of NeurosurgeryLondon Health Sciences CentreUK
  3. 3.Department of PathologyLondon Health Sciences CentreUK
  4. 4.Division of Neurosurgery, Department of Clinical Neurological SciencesUniversity of Western OntarioCanada
  5. 5.Brain Tumor Tissue BankLondon Health Sciences CentreUK

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