Breast Cancer Research and Treatment

, Volume 56, Issue 1, pp 67–78

Prognostic factors predicting survival from first recurrence in patients with metastatic breast cancer: analysis of 439 patients

  • Amelia Insa
  • Ana Lluch
  • Felipe Prosper
  • Isabel Marugan
  • Angel Martinez‐Agullo
  • Javier Garcia‐Conde
Article

DOI: 10.1023/A:1006285726561

Cite this article as:
Insa, A., Lluch, A., Prosper, F. et al. Breast Cancer Res Treat (1999) 56: 67. doi:10.1023/A:1006285726561

Abstract

We have analyzed retrospectively 439 women with recurrent breast cancer, followed at a single institution, in order to define potential prognostic factors for survival at the time of first recurrence. Median age at the time of first recurrence was 58 and the median disease free interval (DFI) from initial diagnoses to recurrence was 33 months. Thirteen percent of the patients did not receive any adjuvant therapy while 87% received different combinations of chemotherapy, radiotherapy and hormone therapy as adjuvant treatment. With a median follow‐up of 44 months from the time of recurrence the median survival (MSR) was 24 months (SE 1.24) and five‐year overall survival was 18% (SE 2.02). On the univariate analysis, pathological tumor size (pT) at diagnosis (p<0.0006), axillary lymph node status at diagnosis (p<0.00001), negative estrogen receptor (ER) status (p<0.0001), negative progesterone receptor (PgR) status (p<0.0001), adjuvant chemotherapy (p<0.001), disease free interval (p<0.00001), location of recurrence (p<0.0002) and number of metastatic sites (≥3: p, ≤ 0.0003), were significantly associated with shorter survival from first relapse. On the multivariate analysis, only the site of recurrence, axillary lymph node status at diagnosis, ER status and DFI remained independently associated with decreased MSR after first relapse.

disease free interval dominant site of relapse estrogen receptor status median survival post‐relapse metastatic breast cancer prognostic factors 

Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Amelia Insa
    • 1
  • Ana Lluch
    • 1
  • Felipe Prosper
    • 1
  • Isabel Marugan
    • 1
  • Angel Martinez‐Agullo
    • 2
  • Javier Garcia‐Conde
    • 1
  1. 1.Department of Hematology and Medical OncologyHospital Clinico UniversitarioValenciaSpain
  2. 2.Department of SurgeryHospital Clinico UniversitarioValenciaSpain

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