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Journal of Neuro-Oncology

, Volume 44, Issue 1, pp 15–21 | Cite as

An Indwelling Brachytherapy Balloon Catheter: Potential Use as an Intracranial Light Applicator for Photodynamic Therapy

  • Henry Hirschberg
  • Steen Madsen
  • Knut Lote
  • Tuan Pham
  • Bruce Tromberg
Article

Abstract

An indwelling balloon applicator developed for postoperative intracavity afterloading brachytherapy was evaluated for photodynamic therapy (PDT). Following tumor resection, the applicator is positioned in the center of the resultant cavity and the balloon is inflated with a scattering solution. The liquid-filled balloon stabilizes the resection cavity ensuring a constant and simple geometric shape during treatment. The catheter is brought out through the skin and adjusted so that 1–2 cm projects above the scalp surface.

Measurements of light distribution in a phantom model surrounding the balloon catheter, show that it may be used to deliver sufficiently uniform light doses during PDT. The light distribution is uniform to within 5% when the balloon is filled with a scattering medium. Based on simple assumptions, it is shown that the applicator can be used to deliver a sufficient optical dose to brain tissue at a depth of 1 cm in less than 1 h.

The applicator has already been used for brachytherapy in 72 patients with few complications. A new treatment protocol employing the combination of both fractionated intracavity brachytherapy and PDT is currently being planned.

brain tumor brachytherapy photodynamic therapy 

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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Henry Hirschberg
    • 1
  • Steen Madsen
    • 2
  • Knut Lote
    • 1
  • Tuan Pham
    • 3
  • Bruce Tromberg
    • 3
  1. 1.Department of Neurosurgery, Rikshospitalet, Department of OncologyThe Norwegian Radium HospitalOsloNorway
  2. 2.Department of Health PhysicsUniversity of NevadaLas VegasUSA
  3. 3.Laser Microbeam and Medical Program (LAMMP)Beckman Laser Institute and Medical Clinic, University of CaliforniaIrvineUSA

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