Health Status in 52 Long-term Survivors of Pediatric Brain Tumors
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The percentage of children who survive childhood brain tumors is increasing. A number have neurological and other sequelae which impact on the quality of their survival. We reviewed long-term survivors using a standardized health status instrument. The mothers of 52 survivors of brain tumors were surveyed. Eight different aspects (attributes) of health status were scored. The first 6 of these attributes were scored in a health status index (HSI) developed at McMaster University. Subgroup analysis was performed. Limitation in the quality of life was found in one of the 8 attributes in all but 2 of the subjects. The health status index (HSI) score using the first 6 attributes of this survey had a median of 0.73 (range 0.16–1.00). This score is lower than that found in previously surveyed survivors of leukemia or other childhood cancers. Examination of age at diagnosis, extent of surgery, sex and therapeutic modalities used showed no correlation with HSI score. Those with supratentorial astrocytomas had a lower HSI score (0.65) than those with infratentorial astrocytomas (0.85) (p=0.05). Children with craniopharyngiomas had a poor score (0.64). This survey shows that the survivors of brain tumors have an appreciable burden of morbidity. Most have deficits in health status that affect many areas of their lives. Apart from site of the primary tumor, there was little correlation between subgroups studied and health status. The health status of children who survive brain tumors is lower than that of survivors of other childhood malignancies.
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- 1.Barr RD, Feeny D, Furlong W, Weitzman S, Torrance GW: Apreference-based approach to health-related quality of life for children with cancer. Inter J Pediatr Hematol Oncol 2: 305–315, 1995Google Scholar
- 8.Martinez-Climent J, Castel Sanchez V, Esquembre C, Verquer Miralles A, Ferris Jortajuda J: Scale for assessing quality of life of children survivors of cranial posterior fossa tumors. J Neuro-Oncol 22: 67–76, 1994Google Scholar
- 9.Donavan K, Sanson-Fisher RW, Redman S: Measuring the quality of life in cancer patients. J Clin Oncol 7: 959, 1989Google Scholar
- 10.Feeny D, FurlongW, Barr RD, TorranceGW, Rosenbaum P, Weitzman S: A comprehensive multi-attribute system for classifying the health status of survivors of childhood cancer. J Clin Oncol 10: 923–928, 1989Google Scholar
- 11.Feeney D, TorranceGW, Furlong WJ: Health utilities index. In: Spicer B (ed) 'Quality of Life and Pharmacoeconomics in Clinical Trials'. 2nd ed. Philadelphia: Lippincott-Raven, 1996, pp 239–252Google Scholar
- 12.Torrance GW, Boyle MH, Horwood SP: Application of multi-attribute utility theory to measure social preferences for health states. Operations Research 30: 1043–1069, 1992Google Scholar
- 13.Cadman D, Goldsmith C, TorranceGW, Boyle MH, Furlong W: Development of a health status index for Ontario children. Final report to the Ontario Ministry of Health on research grant DM648 (00633). Hamilton, Ontario: McMaster University, 1986Google Scholar
- 14.Cadman D, Goldsmith C, Bashim P: Values, preferences and decisions in the care of children with developmental disabilities. Dev Behav Pediatr 5: 60–64, 1984Google Scholar
- 15.Billson AL, Walker DA: Assessment of health status in survivors of cancer. Arch Dis Child 70: 200–204, 1994Google Scholar
- 16.Feeny D, Leiper A, Barr RD, Furlong W, Torrance GW, Rosenbaum P, Weitzman S: The comprehensive assessment of health status in survivors of childhood cancer: application to high-risk acute lymphoblastic leukaemia. B J Cancer 67: 1047–1052, 1993Google Scholar
- 21.Duffner PK, Cohen ME (eds): Craniopharyngiomas. In 'Brain Tumors in Children' 2nd ed. Raven Press Books LTD, New York, 1994Google Scholar