Kinematic analysis of left ventricular deformation in myocardial infarction using magnetic resonance cardiac tagging

  • Frank W.L. Aelen
  • Theo Arts
  • Dave G.M. Sanders
  • Guillaume R.P. Thelissen
  • Frits W. Prinzen
  • Robert S. Reneman


The Magnetic Resonance (MR) tagging technique provides detailed information about 2D motion in the plane of observation. Interpretation of this information as a reflection of the 3D motion of the entire cardiac wall is a major problem. In finite element models of the mechanics of the infarcted heart, an infarcted region causes motional asymmetry, extending far beyond the infarct boundary. Here we present a method to quantify such asymmetry inamplitude and orientation. For this purpose images of a short-axis cross-section of the ejecting left ventricle were acquired from 9 healthy volunteers and 5 patients with myocardial infarction. MR-tags were applied in a 5 mm grid at end-diastole. The tags were tracked by video-image analysis. Tag motion was fitted to a kinematic model of cardiac motion. For the volunteers and the patients the center of the cavity displaced by about the same amount(p=0.11) during the ejection phase: 3.8 ± 1.4 and 3.0 ± 0.9 mm (mean ± sd), respectively. Cross-sectional rotation and the decrease in cross-sectional area of the cavity were both greater in the volunteers than in the patients: 6.4 ± 1.5 vs. 3.0 ± 0.8 degrees (p<0.001), and 945 ± 71 vs. 700 ± 176 mm 2 (p=0.02), respectively. In the patients, asymmetry of wall motion, as expressed by a sine wave dependency of contraction around the circumference, was significantly enlarged (p=0.02). The proposed method of kinematic analysis can be used to assess cardiac deformation in humans. We expect that by analyzing images of more cross-sections simultaneously, the 3D location and the degree of infarction can be assessed efficiently.

left ventricle magnetic resonance imaging spatial modulation of magnetization myocardial deformation Myocardial infarction 


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  1. 1.
    Lima JAC, Ferrari VA, Reichek N, Kramer CM, Palmon L, Llaneras MR, et al. Segmental motion and deformation of transmurally infarcted myocardium in acute postinfarct period. Am J Physiol 1995; 268 (Heart Circ. Physiol. 37): H1304-12.Google Scholar
  2. 2.
    Maier SE, Fischer SE, McKinnon GC, Hess OM, Krayenbuehl HP, Boesiger P. Evaluation of left ventricular segmental wall motion in hypertrophic cardiomyopathy with myocardial tagging. Circulation 1992; 86: 1919-28.Google Scholar
  3. 3.
    Prinzen FW, Arts T, Hoeks APG, Reneman RS. Discrepancies between myocardial blood flow and fiber shortening in the ischemic border zone as assessed with video mapping of epicardial deformation. Eur J Physiol 1989; 415: 220-9.Google Scholar
  4. 4.
    Young AA, Kramer CM, Ferrari VA, Axel L, Reichek N. Three-dimensional left ventricular deformation in hypertrophic cardiomyopathy. Circulation 1994; 90: 854-67.Google Scholar
  5. 5.
    Axel L, Dougherty L. MR imaging of motion with spatial modulation of the magnetization. Radiology 1989; 171: 841-5.Google Scholar
  6. 6.
    Axel L, Gonçalves RC, Bloomgarden D. Regional heart wall motion: two-dimensional analysis and functional imaging with MR imaging. Radiology 1992; 183: 745-50.Google Scholar
  7. 7.
    Zerhouni EA, Parish DM, Rogers WJ, Yang A, Shapiro EA. Human heart: tagging with MR imaging — a method for non-invasive assessment of myocardial motion. Radiology 1988; 169: 59-63.Google Scholar
  8. 8.
    McVeigh ER. MRI of myocardial function: motion tracking techniques. Magn Reson Imaging 1996; 14(2): 137-50.Google Scholar
  9. 9.
    Young AA, Imai H, Chang CN, Axel L. Two-dimensional left ventricular deformation during systole using Magnetic Resonance imaging with Spatial Modulation of Magnetization. Circulation 1994; 89: 740-52.Google Scholar
  10. 10.
    Kraitchman DL, Young AA, Chang C-N, Axel L. Semiautomatic tracking of myocardial motion in MR-tagged images. IEEE T Med Imaging 1995; 14(3): 422-33.Google Scholar
  11. 11.
    Kumar S, Goldgof D. Automatic tracking of SPAMM grid and the estimation of deformation parameters from cardiac MR images. IEEE T Med Imaging 1994; 13(1): 122-32.Google Scholar
  12. 12.
    Axel L, Bloomgarden DC, Chang C-N, Fayad ZA, Kraitchman DL, Young AA. An integrated program for 2-D and 3-D analysis of heart wall motion from Magnetic Resonance Imaging; Computers in Cardiology, Vienna, 1995: 625-7.Google Scholar
  13. 13.
    Bovendeerd PHM, Arts T, Delhaas T, Huyghe JM, Van Campen DH, Reneman RS. Regional wall mechanics in the ischemic left ventricle: numerical modeling and dog experiments. Am J Physiol 1996; 270(270): H398-410.Google Scholar
  14. 14.
    Lessick J, Sideman S, Azhari H, Shapiro E, Weiss JL, Beyar R. Evaluation of regional load in accute ischemia by three-dimensional curvatures analysis of the left ventricle. Ann Biomed Eng 1993; 21: 147-61.Google Scholar
  15. 15.
    Press WH, Flannery BP, Teukolsky SA, Vetterling WT. Numerical recipes — The art of scientific computing. Cambridge: Cambridge University Press, 1988.Google Scholar
  16. 16.
    Muijtjens AMM, Roos JMA, Arts T, Hasman A, Reneman RS. Extrapolation of incomplete marker tracks by Lower Rank Approximation. Int J Biomed Comput 1993; 33: 219-39.Google Scholar
  17. 17.
    Arts T, Hunter WC, Douglas A, Muytjens AMM, Reneman RS. Description of the deformation of the left ventricle by a kinematic model. J Biomechanics 1992; 25(10): 1119-27.Google Scholar
  18. 18.
    Clark NR, Reichek N, Bergey P, Hoffman EA, Brownson D, Palmon L, et al. Circumferential myocardial shortening in the normal human left ventricle — assessment by Magnetic Resonance imaging using Spatial Modulation of Magnetization. Circulation 1991; 84: 67-74.Google Scholar
  19. 19.
    Guttman MA, Prince JL, McVeigh ER. Tag and contour detection in tagged MR images of the left ventricle. IEEE Trans Med Imaging 1994; 13(1): 74-88.Google Scholar
  20. 20.
    O'Dell WG, Moore CC, Hunter WC, Zerhouni EA, McVeigh ER. Three-dimensional myocardial deformations: calculation with displacement field fitting to tagged MR images. Radiology 1995; 195: 829-35.Google Scholar
  21. 21.
    Kramer CM, Rogers WJ, Theobald TM, Power TP, Petruolo S, Reichek N. Remote noninfarcted region dysfunction soon after first anterior myocardial infarction. A Magnetic Resonance Tagging study. Circulation 1996; 94: 660-6.Google Scholar
  22. 22.
    Marcus JT, Gotte JW, Van Rossum AC, Kuijer JPA, Heethaar RM, Axel L, et al. Myocardial function in infarcted and remote regions early after infarction in man: Assessment by Magnetic Resonance tagging and strain analysis. MRM 1997; 38: 803-10.Google Scholar
  23. 23.
    Fischer SE, McKinnon GC, Maier SE, Boesiger P. Improved myocardial tagging contrast. Magn Reson Med 1993; 30: 191-200.Google Scholar
  24. 24.
    McVeigh ER, Atalar E. Cardiac tagging with breath-hold cine MRI. Magn Res Med 1992; 28: 318-27.Google Scholar
  25. 25.
    Tang C, McVeigh ER, Zerhouni EA. Multi-shot EPI for improvement of myocardial tagging contrast: comparison with segmented SPGR. Magn Res Med 1995; 33(3): 443-7.Google Scholar
  26. 26.
    Qi P, Thomsen C, Ståhlberg F, Henriksen O. Normal left ventricular wall motion measured with two-dimensional myocardial tagging. Acta Radiol 1993; 34(5): 450-6.Google Scholar
  27. 27.
    Rogers WJ, Shapiro EP, Weiss JL, Buchalter MB, Rademakers FE, Weisfeldt ML, et al. Quantification of and correction for left ventricular long-axis shortening by Magnetic Resonance tissue tagging and slice isolation. Circulation 1991; 84: 721-31.Google Scholar
  28. 28.
    Azhari H, Weiss JL, Rogers WJ, Siu CO, Zerhouni EA, Shapiro EP. Noninvasive quantification of principal strains in normal canine hearts using tagged MRI images in 3-D. Am J Physiol 1993; 264(Heart Circ Physiol 33): H205-16.Google Scholar
  29. 29.
    Young AA, Axel L. Three-dimensional motion and deformation of the heart wall: estimation with Spatial Modulation of Magnetization — a model-based approach. Radiology 1992; 185: 241-7.Google Scholar

Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Frank W.L. Aelen
    • 1
  • Theo Arts
    • 1
  • Dave G.M. Sanders
    • 2
  • Guillaume R.P. Thelissen
    • 2
  • Frits W. Prinzen
    • 3
  • Robert S. Reneman
    • 3
  1. 1.Departments of Biophysics, Cardiovascular Research Institute MaastrichtMaastricht Uni-versityMaastrichtThe Netherlands
  2. 2.Department of Diagnostic RadiologyUniversity Hospital MaastrichtMaastrichtThe Netherlands
  3. 3.Departments of Physiology, Cardiovascular Research Institute MaastrichtMaastricht Uni-versityMaastrichtThe Netherlands

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