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Breast Cancer Research and Treatment

, Volume 53, Issue 1, pp 87–91 | Cite as

Male breast cancer in the hereditary nonpolyposis colorectal cancer syndrome

  • Jeff Boyd
  • Esther Rhei
  • Mark G. Federici
  • Patrick I. Borgen
  • Patrice Watson
  • Barbara Franklin
  • Beth Karr
  • Jane Lynch
  • Stephen J. Lemon
  • Henry T. Lynch
Article

Abstract

A male member of a large HNPCC kindred, affected by primary malignancies of the breast and colon, was identified. This individual was found to harbor a germline mutation of the MLH1 mismatch repair gene previously shown to segregate with disease in this kindred. The breast tumor exhibited somatic reduction to homozygosity for the MLH1 mutation, and microsatellite instability was evident in the breast tumor. We conclude that hereditary male breast cancer can occur as an integral tumor in the HNPCC syndrome.

hereditary HNPCC male breast cancer MLH1 microsatellite instability mismatch repair 

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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Jeff Boyd
    • 1
  • Esther Rhei
    • 1
  • Mark G. Federici
    • 1
  • Patrick I. Borgen
    • 1
  • Patrice Watson
    • 2
  • Barbara Franklin
    • 2
  • Beth Karr
    • 2
  • Jane Lynch
    • 2
  • Stephen J. Lemon
    • 2
  • Henry T. Lynch
    • 2
  1. 1.Department of SurgeryMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  2. 2.Department of Preventive Medicine and Public HealthCreighton UniversityOmahaUSA

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