Breast Cancer Research and Treatment

, Volume 46, Issue 2–3, pp 215–223

Meta-analyses of dietary fats and mammary neoplasms in rodent experiments

  • Michael P. Fay
  • Laurence S. Freedman
Article

Abstract

We review two meta-analyses of experiments on dietary fat and mammary tumor incidence in rodents, emphasizing a recent meta-analysis on the effects of different types of dietary fatty acids. This analysis shows that n-6 polyunsaturated fatty acids most strongly enhance mammary tumors in rodents, and saturated fats also enhance these tumors but less strongly. Further, the analysis shows that energy restriction protects against mammary tumors. We show that these results agree qualitatively with estimates of effects on human breast cancer derived from international correlations.

breast cancer monounsaturated fats n-3 fatty acids n-6 fatty acids saturated fats 

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References

  1. 1.
    Tannenbaum A: The dependence of tumor formation on the degree of caloric restriction. Cancer Res 5:609–615, 1945Google Scholar
  2. 2.
    Tannenbaum A: The dependence of tumor formation on the composition of the caloric-restricted dict as well as on the degree of restriction. Cancer Res 5:616–625, 1945Google Scholar
  3. 3.
    Gammal EB, Carroll KK, Plunkett ER: Effects of dietary fat on mammary carcinogenesis by 7,12-dimethylbenzanthracene in rats. Cancer Res 27:1737–1742, 1967PubMedGoogle Scholar
  4. 4.
    Carroll KK, Khor HT: Dietary fat in relation to tumorigenesis. Progr Biochem Pharmacol 10:308–353, 1975Google Scholar
  5. 5.
    Welsch CW: Review of the effects of dietary fat on experimental mammary gland tumorigenesis: role of lipid peroxidation. Free Radical Biology and Medicine 18:757–773, 1995CrossRefPubMedGoogle Scholar
  6. 6.
    Noguchi M, Rose DP, Earashi M, Miyazaki I: The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma. Oncology 52:265–271, 1995PubMedGoogle Scholar
  7. 7.
    Welsch CW: Relationship between dietary fat and experimental mammary tumorigenesis: a review and critique. Cancer Res (Suppl) 52:2040s–2048s, 1992PubMedGoogle Scholar
  8. 8.
    Cave WT: Dietary n-3 (θ-3) polyunsaturated fatty acid effects on animal tumorigenesis. FASEB J 5: 2160–2166, 1991PubMedGoogle Scholar
  9. 9.
    Carroll KK, Gammal EB, Plunkett ER: Dietary fat and mammary cancer. Can Med Assoc J 98:590–594, 1968PubMedGoogle Scholar
  10. 10.
    Prentice RL, Kakar F, Hursting S, Sheppard L, Klien R, Kushi LH: Aspects and rationale for the Women's Health Trial. J Natl Cancer Inst 80:802–814, 1988PubMedGoogle Scholar
  11. 11.
    Prentice RL, Sheppard L: Dietary fat and cancer: consistency of the epidemiologic data, and disease prevention that may follow from a practical reduction in fat consumption. Cancer Causes and Control 1:81–97, 1990PubMedGoogle Scholar
  12. 12.
    Howe GR, Hirohata T, Hislop TG, Iscovich JM, Yuan J-M, Katsouyanni K, Lubin F, Marubini E, Modan B, Rohan T, Toniolo P, Shunzhang Y: Dietary factors and risk of breast cancer: combined analysis of 12 case-control studies. J Natl Cancer Inst 82:561–569, 1990PubMedGoogle Scholar
  13. 13.
    Boyd NF, Martin IJ, Noffel M, Lockwood GA, Tritchler DL: A meta-analysis of studies of dietary fat and breast cancer risk. Br J Cancer 68:627–636, 1993PubMedGoogle Scholar
  14. 14.
    Tominaga S: Cancer incidence in Japanese in Japan, Hawaii, and Western United States. Monogr Natl Cancer Inst 69:83–92, 1985Google Scholar
  15. 15.
    Hunter DJ, Spiegelman D, Adami H-O, Beeson L, van den Brandt PA, Folsom AR, Fraser GE, Goldbohm RA, Graham S, Howe GR, Kushi LH, Marshall JR, McDermott A, Miller AB, Speizer FE, Wolk A, Yaun S-S, Willett W: Cohort studies of fat intake and the risk of breast cancer — a pooled analysis. N Engl J Med 334:356–361, 1996Google Scholar
  16. 16.
    Women's Health Initiative Study Group. Design of the Women's Health Initiative clinical trial and observational study. to appear in Controlled Clinical Trials.Google Scholar
  17. 17.
    Prentice RL: Dietary fat reduction as a hypothesis for the prevention of postmenopausal breast cancer, and a discussion of hypothesis testing research strategies. In: Weisburger EK (ed) Diet and Breast Cancer. "Advances in Experimental Medicine and Biology" series, Plenum Press, New York, 1994, pp 25–34Google Scholar
  18. 18.
    Prentice RL: Measurement error and results from analytic epidemiology: dietary fat and breast cancer. J Natl Cancer Inst 88:1738–1747, 1996PubMedGoogle Scholar
  19. 19.
    Pariza MW, Boutwell RK: Historical perspective: calories and energy expenditure in carcinogenesis. Am J Clin Nutr 45:151–156, 1987PubMedGoogle Scholar
  20. 20.
    Freedman LS, Clifford C, Messina M: Analysis of dietary fat, calories, body weight, and the development of mammary tumors in rats and mice: a review. Cancer Res 50:5710–5719, 1990PubMedGoogle Scholar
  21. 21.
    Fay MP, Freedman LS, Clifford C, Midthune DN: Effect of different types and amounts of fat on the development of mammary tumors in rodents: a review. (to appear in Cancer Res)Google Scholar
  22. 22.
    U.S. Department of Agriculture. Composition of Foods: Fats and Oils. U.S. Government Printing Office, Washington D.C. 20402, 1979Google Scholar
  23. 23.
    Atwater WO, Bryand AP: Connecticut (Storrs) agricultural experiment station 12th annual report, pp 73–123, Storrs, CT, 1900Google Scholar
  24. 24.
    Freedman LS, Clifford C: Meta-analysis of animal experiments: elucidating relationships between dietary fat and mammary tumor development in rodents. In: Weisburger EK (ed) Diet and Breast Cancer. "Advances in Experimental Medicine and Biology" series, Plenum Press, New York, 1994, pp 93–100Google Scholar
  25. 25.
    Freedman LS: Meta-analysis of animal experiments on dietary fat intake and mammary tumors. Stat Med 13:709–718, 1994PubMedGoogle Scholar
  26. 26.
    Fay MP, Graubard BI, Freedman LS, Midthune DN: Conditional logistic regression with sandwich estimators: application to a meta-analysis. unpublished manuscript 1996Google Scholar
  27. 27.
    Horrobin DF: The role of essential fatty acids and prostaglandins in breast cancer. In: Reddy BS, Cohen LA (eds) Diet, Nutrition and Cancer: A Critical Evaluation. Volume I: Macronutrients and Cancer. CRC Press, Boca Raton FL, 1986Google Scholar
  28. 28.
    Fleiss, JL: Statistical Methods for Rates and Proportions, 2d edition. John Wiley & Sons, New York, 1981Google Scholar
  29. 29.
    Hursting SD, Thornquist M, Henderson MM: Types of dietary fat and the incidence of cancer at five sites. Prev Med 19:242–253, 1990CrossRefPubMedGoogle Scholar
  30. 30.
    Waterhouse J, Shanmugaratham K, Muir C: Cancer Incidence in Five Continents, vol. 4, IARC, Lyon, France, 1982Google Scholar
  31. 31.
    Food and Agriculture Organization of the United Nations. Food balance sheets, 1975–1977 average. FAO, Rome, 1980Google Scholar
  32. 32.
    Lancet [editorial]. Eskimo diets and diseases. Lancet 1(8334):1139-1141, 1983Google Scholar
  33. 33.
    Kaizer L, Boyd NF, Kriukov V, Tritchler D: Fish consumption and breast cancer risk: an ecological study. Nutr Cancer 12:61–68, 1989PubMedGoogle Scholar
  34. 34.
    Sasaki S, Horacsek M, Kesteloot H: An ecological study of the relationship between dietary fat intake and breast cancer mortality. Prev Med 22:187–202, 1993CrossRefPubMedGoogle Scholar
  35. 35.
    Caygill CPJ, Charlett A, Hill MJ: Fat, fish, fish oil and cancer. Br J Cancer 74:159–164, 1996PubMedGoogle Scholar
  36. 36.
    Martin-Moreno JM, Willett WC, Gorgojo L, Banegas JR, Rodriguez-Artalejo F, Fernandez-Rodriguez JC, Maisonneuve P, Boyle P: Dietary fat, olive oil intake and breast cancer risk. Int J Cancer 774–780, 1994Google Scholar
  37. 37.
    Trichopoulou A, Katsouyanni K, Stuver S, Tzala L, Gnardellis C, Rimm E, Trichopoulos D: Consumption of olive oil and specific food groups in relation to breast cancer risk in Greece. J Natl Cancer Inst 87:110–116, 1995PubMedGoogle Scholar
  38. 38.
    La Vecchia C, Negri E, Franceschi S, Decarli A, Giacosa A, Lipworth L: Olive oil, other dietary fats, and the risk of breast cancer (Italy). Cancer Causes and Control 6:545–550, 1995PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • Michael P. Fay
    • 1
  • Laurence S. Freedman
    • 1
  1. 1.Biometry Branch, Division of Cancer Prevention and ControlNational Cancer InstituteBethesdaUSA

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