Breast Cancer Research and Treatment

, Volume 46, Issue 2–3, pp 215–223

Meta-analyses of dietary fats and mammary neoplasms in rodent experiments

  • Michael P. Fay
  • Laurence S. Freedman


We review two meta-analyses of experiments on dietary fat and mammary tumor incidence in rodents, emphasizing a recent meta-analysis on the effects of different types of dietary fatty acids. This analysis shows that n-6 polyunsaturated fatty acids most strongly enhance mammary tumors in rodents, and saturated fats also enhance these tumors but less strongly. Further, the analysis shows that energy restriction protects against mammary tumors. We show that these results agree qualitatively with estimates of effects on human breast cancer derived from international correlations.

breast cancer monounsaturated fats n-3 fatty acids n-6 fatty acids saturated fats 


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Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • Michael P. Fay
    • 1
  • Laurence S. Freedman
    • 1
  1. 1.Biometry Branch, Division of Cancer Prevention and ControlNational Cancer InstituteBethesdaUSA

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