Journal of Neuro-Oncology

, Volume 37, Issue 3, pp 285–293 | Cite as

Bone marrow metastasis in astrocytic gliomata

  • E. Hsu
  • D. Keene
  • E. Ventureyra
  • M.A. Matzinger
  • C. Jimenez
  • H.S. Wang
  • L. Grimard


With the increasing survival time of many pediatric patients with malignancies, unexpected symptoms or signs require diligent search for rare complications or second cancers related to the disease or treatment. We recently encountered a patient with extensive glioblastoma multiforme who developed pancytopenia six months after completion of treatment with craniospinal radiation and chemotherapy with etoposide and cyclophosphamide. Bone marrow aspirate and biopsy confirmed bone marrow metastasis from the brain tumor. He showed good partial remission with chemotherapy with carmustine and cis-platinum as demonstrated by serial bone marrow aspirate for cytology and cytogenetics and enjoyed good quality of life for eight months. 14 other patients with astrocytic glioma, two of whom are children, are reported in the literature to have diffuse bone marrow metastasis. Therefore, in patients with malignant astrocytic tumor, bone marrow metastasis, though not common, should be considered when bone pain or cytopenias occur, especially when prolonged.

astrocytoma extraneural metastasis bone marrow 


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Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • E. Hsu
    • 1
  • D. Keene
    • 1
  • E. Ventureyra
    • 1
  • M.A. Matzinger
    • 1
  • C. Jimenez
    • 1
  • H.S. Wang
    • 1
  • L. Grimard
    • 2
  1. 1.Pediatric Neuro-oncology ServiceChildren's Hospital of EasternOntario
  2. 2.Department of Radiation OncologyOttawa Regional Cancer Centre and the University of OttawaOttawaCanada

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