Breast Cancer Research and Treatment

, Volume 44, Issue 1, pp 1–22 | Cite as

Defining a role for c-Myc in breast tumorigenesis

  • Sharyl J. Nass
  • Robert B. Dickson


The proto-oncogene c-myc is commonly amplified and overexpressed in human breast tumors, and the tumorigenic potential of c-myc overexpression in mammary tissue has been confirmed by both in vitro and in vivo models of breast cancer. However, the mechanisms by which Myc promotes tumorigenesis are not well understood. Recent evidence indicates that Myc can promote cell proliferation as well as cell death via apoptosis. These studies provide new insight and impetus in defining a role for c-Myc in breast tumorigenesis and may point toward novel targets for breast cancer therapy.

apoptosis cell cycle amplification overexpression breast neoplasia c-Myc 


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Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • Sharyl J. Nass
    • 1
  • Robert B. Dickson
    • 1
  1. 1.Department of Cell Biology and Vincent T. Lombardi Cancer CenterGeorgetown UniversityWashington DCUSA

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