Breast Cancer Research and Treatment

, Volume 47, Issue 2, pp 111–120

Insulin and related factors in premenopausal breast cancer risk

  • M. Elisabeth Del Giudice
  • I. George Fantus
  • Shereen Ezzat
  • Gail McKeown-Eyssen
  • David Page
  • Pamela J. Goodwin
Article

DOI: 10.1023/A:1005831013718

Cite this article as:
Del Giudice, M.E., Fantus, I.G., Ezzat, S. et al. Breast Cancer Res Treat (1998) 47: 111. doi:10.1023/A:1005831013718

Abstract

Background: Insulin and insulin-like growth factor I (IGF-I) are important mitogens in vitro and in vivo. It has been hypothesized that these factors may play an important role in the development of breast cancer. Methods: A case-control study comparing plasma insulin levels in 99 premenopausal women with newly diagnosed node-negative invasive carcinoma of the breast and 99 age-matched controls with incident biopsied non-proliferative breast disease (NP) was conducted. Women with known diabetes were excluded. Results: For the entire study group, mean age was 42.6 ± 5.1 years and mean weight was 62.9 ± 10.3 kg. After adjustment for age and weight, elevated insulin levels were significantly associated with breast cancer, Odds Ratio (OR) for women in the highest insulin quintile versus the lowest quintile=2.83 (95% Confidence Interval [CI] 1.22–6.58). There were no statistically significant differences between cases and controls for IGF-I and IGFBP-1 levels. However, after adjustment for age, the association between plasma levels of insulin-like growth factor binding protein 3 (IGFBP-3) and breast cancer approached statistical significance; OR for highest quintile versus lowest quintile of IGFBP-3 being 2.05 (95% CI, 0.93–4.53). All results were independent of diet and other known risk factors for breast cancer. Conclusion: Circulating insulin levels and possibly IGFBP-3 levels are elevated in women with premenopausal breast cancer. This association may reflect an underlying syndrome of insulin resistance that is independent of obesity.

insulin breast cancer premenopausal risk 

Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • M. Elisabeth Del Giudice
    • 1
    • 2
    • 3
  • I. George Fantus
    • 1
    • 4
  • Shereen Ezzat
    • 5
  • Gail McKeown-Eyssen
    • 3
  • David Page
    • 6
  • Pamela J. Goodwin
    • 1
    • 2
  1. 1.Department of MedicineMount Sinai HospitalCanada
  2. 2.Division of Clinical EpidemiologySamuel Lunenfeld Research InstituteCanada
  3. 3.Department of Preventive Medicine and BiostatisticsUniversity of TorontoTorontoCanada
  4. 4.Banting and Best Diabetes CentreUniversity of TorontoTorontoCanada
  5. 5.Department of MedicineWellesley Hospital and Department of Medicine at Wellesley HospitalCANADA
  6. 6.Department of Pathology atVanderbilt UniversityNashvilleUSA

Personalised recommendations