Journal of Neuro-Oncology

, Volume 35, Issue 2, pp 161–167 | Cite as

Treatment and outcome of brain metastasis as first site of distant metastasis from breast cancer

  • W. Boogerd
  • A.A.M. Hart
  • I.S. Tjahja


Twenty-eight consecutive patients with breast cancer were analyzedwho presented with a single brain metastasis asfirst site of distant metastasis. The response tosurgery with postoperative radiation therapy (RT) (9 patients)and to non-surgical therapy as first-line treatment was100% and 89% respectively with a significant differencein median recurrence-free intervals of 23 months andof 5 months respectively (p=0.033). Retreatmentof a local relapse by surgery (± RT,± chemotherapy) or by non-surgical treatment resulted ina response in 6 of the 7 operatedpatients and in 5 of the 6 non-operatedpatients with a median duration of response of7 months (range 2–20 months) and of 3months (range 2–4 months) respectively. The overall mediansurvival of the 28 patients with a singlebrain metastasis was 16 months (range 2–39 months).The median survival in the primarily operated patientswas 23 months, in the primarily not-operated group10 months, and in the never-operated group 9months. In comparison, the response to non-surgical treatmentin 20 consecutive patients who presented with multiplebrain metastases as first site of distant metastasiswas 55% with a median recurrence free intervalof 4 months. The median survival in thisgroup was 4 months, which was significantly shorterthan survival of patients with single brain metastasis(p=0.0036). These results suggest that breastcancer patients with a single brain metastasis asfirst presentation of relapse constitute a specific subgroupwith a favorable response to treatment and along survival especially if they can be treatedby surgery with postoperative RT.

brain metastasis breast cancer surgery radiotherapy chemotherapy 


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Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • W. Boogerd
    • 1
  • A.A.M. Hart
    • 2
  • I.S. Tjahja
    • 3
  1. 1.Departments of NeurologyThe Netherlands
  2. 2.RadiotherapyThe Netherlands
  3. 3.Cancer Institute/Antonie van LeeuwenhoekhuisAmsterdamThe Netherlands

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