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Journal of Neuro-Oncology

, Volume 34, Issue 1, pp 61–78 | Cite as

Oligodendrogliomas. Part II: A new grading system based on morphological and imaging criteria

  • Catherine Daumas-Duport
  • Marie-Louise Tucker
  • Harry Kolles
  • Pascale Cervera
  • Fréderic Beuvon
  • Pascale Varlet
  • Naoko Udo
  • Maria Koziak
  • Jean-Paul Chodkiewicz
Article

Abstract

This second part of our study of ‘pure’ oligodendrogliomas focuses on survival data analysis. In order to identify potentially useful prognostic factors and to assess the effectiveness of a new grading system, the 79 patients in the previously analyzed series for whom adequate follow-up could be obtained (52%) were entered in the present analysis. Statistical analysis demonstrated that contrast enhancement and endothelial hyperplasia had powerful and similar influence on survival. Median survival with and without contrast enhancement were: 3 versus 11 years, and with or without endothelial hyperplasia were: 3.5 versus 11 years. Conversely, the degree of nuclear atypia and presence or absence of mitosis or necrosis were not correlated with survival. These findings allowed us to devise a simple grading system which discriminates two malignancy grades as follows: absence of endothelial hyperplasia and of contrast enhancement=Grade A, presence of endothelial hyperplasia and/or of contrast enhancement=Grade B. Of the 79 oligodendrogliomas in this study, 59 tumors were categorized as grade A and 20 as grade B. Median survival were: 11 years in grade A and 3.5 years in grade B. Five-year and 8-year survival rates were: 89% and 60% in grade A and: 33% and 15% in grade B. Double blind grading between two independent observers was concordant in 96% of the cases. Application of this simple efficient and reproducible grading scheme should permit reliable comparison of retrospective or prospective therapeutic data emanating from various institutions.

oligodendroglioma grading system prognostic factors outcome radiology 

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Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • Catherine Daumas-Duport
    • 1
  • Marie-Louise Tucker
    • 1
  • Harry Kolles
    • 1
  • Pascale Cervera
    • 1
  • Fréderic Beuvon
    • 1
  • Pascale Varlet
    • 1
  • Naoko Udo
    • 2
  • Maria Koziak
    • 2
  • Jean-Paul Chodkiewicz
    • 2
  1. 1.Department of Pathology-NeurooncologyFrance
  2. 2.Department of NeurosurgeryHôpital Sainte-Anne and Faculté Cochin Port-RoyalParisFrance

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