Journal of Neuro-Oncology

, Volume 33, Issue 1–2, pp 163–169 | Cite as

In vivo diagnosis of human malignant melanoma with positron emission tomography using specific melanoma-seeking 18F-DOPA analogue

  • Yutaka Mishima
  • Yoshio Imahori
  • Chihiro Honda
  • Junichi Hiratsuka
  • Satoshi Ueda
  • Tatsuo Ido


Detection and diagnosis of human malignant melanoma byPositron Emission Tomography (PET) using 18F-10B-L-BPA, a specificmelanogenesis-seeking compound synthesized for use in Boron NeutronCapture Therapy for malignant melanoma (NCT), has beendeveloped. This resulted in a novel, highly effectivemethodology for the selective three dimensional imaging ofmetastatic malignant melanomas, and for accurate determination of10B concentration in the tumor and surrounding tissue,providing almost all diagnostic information necessary for completenon-invasive radiation dose planning in the treatment ofmalignant melanoma both for NCT as well asother therapeutic modalities.

melanoma PET 18F-DOPA analogue melanoma neutron capture therapy 10B-p-boronophenyl-alanine malignant melanoma melanoma brain metastasis 


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Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • Yutaka Mishima
    • 1
  • Yoshio Imahori
    • 2
  • Chihiro Honda
    • 3
  • Junichi Hiratsuka
    • 4
  • Satoshi Ueda
    • 2
  • Tatsuo Ido
    • 5
  1. 1.Mishima Institute for Dermatological ResearchKobe
  2. 2.Department of NeurosurgeryKyoto Prefectural UniversityKyoto
  3. 3.Department of DermatologyHyogo Pref. Kakogawa HospitalJapan
  4. 4.Department of RadiologyKawasaki Medical SchoolKurashiki
  5. 5.Cyclotron and Radioisotope CenterTohoku UniversitySendaiJapan

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