Journal of Neuro-Oncology

, Volume 31, Issue 1, pp 115–122

A possible growth factor role of IL-6 in neuroectodermal tumours

  • E. Candi
  • R.A. Knight
  • A. Spinedi
  • P. Guerrieri
  • G. Melino
Article

DOI: 10.1023/A:1005706019048

Cite this article as:
Candi, E., Knight, R., Spinedi, A. et al. J Neurooncol (1997) 31: 115. doi:10.1023/A:1005706019048

Abstract

Preliminary data have shown that IL-6 may act as an autocrine growth factor to control proliferation. We further characterised the role of IL-6 in tumour growth as an autocrine/paracrine growth factor in neuroectodermal tumours. We evaluated the production and secretion of IL-6 by seven human melanoma, five neuroblastoma and one glioblastoma cell lines. Moreover, we determined their IL-6-dependent growth in serum free-medium or under minimal growth-supplement conditions: IL-6 dependent growth was observed in two non-IL-6 producing melanoma and in one neuroblastoma cell lines. In addition, expression of IL-6 mRNA and peptide was increased by retinoic acid. The data support the hypothesis that IL-6 contributes to neuroectodermal tumour growth, even though it shows a less potent effect than other reported growth factor such as IGF-II.

IL-6 neuroblastoma melanoma retinoic acid 

Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • E. Candi
    • 1
  • R.A. Knight
    • 2
  • A. Spinedi
    • 1
  • P. Guerrieri
    • 1
  • G. Melino
    • 3
  1. 1.IDI-IRCCS Biochemistry Laboratory, Department of Experimental Medicine and Biochemical SciencesUniversity of Rome ‘Tor Vergata’Italy
  2. 2.Department of Cystic FibrosisBrompton Hospital, NHLILondonUK
  3. 3.Department of BiologyUniversity of L'AquilaItaly

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