Journal of Inherited Metabolic Disease

, Volume 23, Issue 4, pp 321–324

The influence of L-dopa on methylation capacity in aromatic L-amino acid decarboxylase deficiency: Biochemical findings in two patients

  • C. Bräutigam
  • R. A. Wevers
  • K. Hyland
  • R. K. Sharma
  • A. Knust
  • G. F. Hoffmann
Article

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REFERENCES

  1. Abeling NGGM, Bräutigam C, Hoffmann GF et al (2000) Pathobiochemical implications of hyperdopaminuria in patients with aromatic L-amino acid decarboxylase deficiency. J. Inherit Metab Dis 23: 325–328.Google Scholar
  2. Hyland K, Clayton PT (1992a) Aromatic L-amino acid decarboxylase deficiency: diagnostic methodology. Clin Chem 38: 2405–2410.Google Scholar
  3. Hyland K, Surtees RAH, Rodeck C, Clayton PT (1992b) Aromatic L-amino acid decarboxylase deficiency: clinical features, diagnosis, and treatment of a new inborn error of neurotransmitter amine synthesis. Neurology 42: 1980–1988.Google Scholar
  4. Hyland K, Chang YT, Arnold LA, Bräutigam C, Sharma RK, Hoffmann G (1998) Aromatic L-amino acid decarboxylase deficiency responsive to levodopa: identification of an active site glycine in exon three. J Inherit Metab Dis 21: 4.Google Scholar
  5. Kuhn W, Roebroek R, Blom H, et al (1998) Elevated plasma levels of homocysteine in parkinson's disease. Eur Neurol 40: 225–227.Google Scholar
  6. Surtees R, Hyland K (1990) L-3,4–Dihydroxyphenylalanine (levodopa) lowers central nervous system S-adenosylmethionine concentrations in humans. J. Neurol Neurosurg Psychiatry 53: 569–572.Google Scholar

Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • C. Bräutigam
    • 1
  • R. A. Wevers
    • 2
  • K. Hyland
    • 3
  • R. K. Sharma
    • 3
  • A. Knust
    • 4
  • G. F. Hoffmann
    • 1
  1. 1.University Children's Hospital MarburgGermany
  2. 2.University Hospital NijmegenThe Netherlands
  3. 3.Institute of Metabolic DiseaseBaylor University Medical CenterDallasUSA
  4. 4.Children's Hospital SiegenGermany

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