Journal of Muscle Research & Cell Motility

, Volume 21, Issue 2, pp 115–130

Actin and the smooth muscle regulatory proteins: a structural perspective

  • Julie L. Hodgkinson

DOI: 10.1023/A:1005697301043

Cite this article as:
Hodgkinson, J.L. J Muscle Res Cell Motil (2000) 21: 115. doi:10.1023/A:1005697301043


The structural details of the smooth muscle acto-myosin interaction and its functional implications have been much discussed in recent years, however other, smooth muscle specific, actin-binding proteins have received much less attention. With increasing technical advances in structural biology a great deal of structural information is now coming to light, information that can provide useful insight into the mechanism of action for many important non-motor actin-binding proteins. The purpose of the review is to distil the current knowledge on the structure, and interaction sites on F-actin, of the major, non-motor actin-binding proteins from smooth muscle, proposed to have a role in regulation. In the light of the recent structural studies the probable roles of the various actin-binding proteins will be discussed with particular reference to structure–function relationships.

Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Julie L. Hodgkinson
    • 1
  1. 1.Imperial College of Science Technology and MedicineThe National Heart and Lung InstituteLondonUK

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