Biotechnology Letters

, Volume 22, Issue 16, pp 1281–1285 | Cite as

Separation of ergot alkaloids by adsorption on silicates

  • Jaroslav Votruba
  • Miroslav Flieger


A mixture of ergot alkaloids (agroclavine, elymoclavine, chanoclavine, and chanoclavine aldehyde) was separated from the Claviceps purpureafermentation broth by adsorption on inorganic adsorbents containing silica. The uptake of alkaloids depended on the concentration of adsorbent and pH. The adsorption capacity for of inorganic materials increased with increasing content of inorganic oxides such as MgO and CaO in the adsorbent. Using statistical thermodynamics, a simple mathematical model describing the multicomponent adsorption equilibrium is proposed and a numerical method suitable for fast computer simulation of multicomponent adsorption was developed.

Claviceps purpurea ergot alkaloids multicomponent adsorption silica sorbent 


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Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Jaroslav Votruba
    • 1
  • Miroslav Flieger
    • 1
  1. 1.Institute of MicrobiologyAcademy of Sciences of the Czech RepublicPrague 4Czech Republic

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