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Biotechnology Letters

, Volume 23, Issue 4, pp 289–293 | Cite as

A DNA fragment from Streptomyces peucetius activates biosynthesis of actinorhodin in Streptomyces lividans and daunomycin in the original strain

  • Grisel Rosabal
  • Caridad Rodríguez
  • Ricardo del Sol
  • Silvia Planas
  • Carlos Vallín
  • Francisco Malpartida
Article

Abstract

A chromosomal DNA fragment from Streptomyces peucetius SGF-107 (a producer of daunomycin) which activates the biosynthesis of two polyketide antibiotics, daunomycin and actinorhodin, has been cloned and sequenced. Partial DNA sequencing of the activating fragment revealed the presence of two open reading frames whose deduced products exhibit similarities with that of other known transcriptional regulators of the MarR and ArsR family, respectively.

anthracycline antibiotic doxorubicin pleiotropic activation 

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Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • Grisel Rosabal
    • 1
    • 2
  • Caridad Rodríguez
    • 1
  • Ricardo del Sol
    • 1
  • Silvia Planas
    • 1
    • 2
  • Carlos Vallín
    • 1
  • Francisco Malpartida
    • 1
  1. 1.Centro de Química FarmacéuticaHavanaCuba
  2. 2.Centro Nacional de BiotecnologíaCampus de la U.A.M.CantoblancoSpain

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