Digestive Diseases and Sciences

, Volume 45, Issue 7, pp 1439–1443 | Cite as

Binding of Hydrogen Sulfide by Bismuth Does Not Prevent Dextran Sulfate-Induced Colitis in Rats

  • Julie K. Furne
  • Fabrizis L. Suarez
  • Stephen L. Ewing
  • John Springfield
  • Michael D. Levitt


Several lines of evidence suggest that ulcerative colitis could be caused by excessive bacterial production of H2S in the colon. A rodent model of colitis involves the feeding of nonabsorbable, carbohydrate-bound sulfate in the form of dextran sulfate or carrageenan. The observation that metronidazole blocks the development of this colitis suggested that the injurious agent could be a sulfur-containing compound (such as H2S) that is released during the bacterial metabolism of the nonabsorbed sulfate. We tested this possibility by feeding rats dextran sulfate, with or without bismuth subsalicylate, a compound that avidly binds H2S. Bismuth subsalicylate reduced the fecal release of H2S in dextran sulfate-treated rats to values well below that of controls. Nevertheless, all the animals developed colitis. We conclude that excessive H2S production does not play a role in the dextran sulfate model of colitis.

hydrogen sulfide bismuth colitis rats 


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Copyright information

© Plenum Publishing Corporation 2000

Authors and Affiliations

  • Julie K. Furne
    • 1
  • Fabrizis L. Suarez
    • 1
  • Stephen L. Ewing
    • 1
  • John Springfield
    • 1
  • Michael D. Levitt
    • 1
  1. 1.Research ServiceMinneapolis VA Medical CenterMinneapolis

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