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Digestive Diseases and Sciences

, Volume 45, Issue 9, pp 1754–1762 | Cite as

Long-Term Effects of Helicobacter pylori Eradication on Intestinal Metaplasia in Patients with Duodenal and Benign Gastric Ulcers

  • Nayoung Kim
  • Seon Hee Lim
  • Kye Heui Lee
  • Shin Eun Choi
  • Hyun Chae Jung
  • In Sung Song
  • Chung Yong Kim
Article

Abstract

This study was conducted to investigate whether or not the eradication of H. pylori could lead to the regression of intestinal metaplasia (IM) in patients with either duodenal ulcer (DU) or benign gastric ulcer (BGU). The initial antral IM grade was 0.21 in the 72 patients of the H. pylori-eradicated DU group, this decreased to 0.17, 0.14, 0.13, and 0.09 after periods of four weeks, one year, two years, and four years, respectively, but without statistical significance. In the corpus of the DU group, where IM grade was low (0.02), there was no detectable change in IM. The initial antral IM grade of 0.69 in the 41 patients of the H. pylori-eradicated BGU group decreased substantially to 0.61, 0.44, and 0.39 after periods of four weeks and one and two years, respectively, but again without statistical significance. The initial corporal IM grade of the BGU group of 0.27 decreased to 0.20, 0.15, and 0.06 after periods of four weeks and one and two years, again without statistical significance. In contrast, the IM grades of the noneradicated DU group (N = 20) and the BGU group (N = 16) showed nearly no change in the antrum and corpus. Gastritis grades of antrum and corpus in the H. pylori-eradicated DU or BGU group significantly decreased with respect to time (P = 0.0001), but there were no significant changes in the corresponding noneradicated groups. Although there was no statistical significance, IM decreased in the antrum and corpus of the stomach with BGU and in antrum of those with DU over a two to four-year period after H. pylori eradication, suggesting the possible reversibility of IM.

Helicobacter pylori intestinal metaplasia eradication duodenal ulcer gastric ulcer 

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Copyright information

© Plenum Publishing Corporation 2000

Authors and Affiliations

  • Nayoung Kim
    • 1
    • 2
  • Seon Hee Lim
    • 1
    • 2
  • Kye Heui Lee
    • 1
    • 2
  • Shin Eun Choi
    • 1
    • 2
  • Hyun Chae Jung
    • 1
    • 2
  • In Sung Song
    • 1
    • 2
  • Chung Yong Kim
    • 1
    • 2
  1. 1.Departments of Internal Medicine and Anatomical PathologyKangnam General Hospital, Public CorporationKorea
  2. 2.Department of Internal MedicineSeoul National University College of Medicine and Liver Research InstituteSeoulKorea

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