Biotechnology Letters

, Volume 21, Issue 6, pp 467–479

Metabolic engineering of plant secondary metabolite pathways for the production of fine chemicals

  • R. Verpoorte
  • R. van der Heijden
  • H.J.G. ten Hoopen
  • J. Memelink
Article

Abstract

The technology of large-scale plant cell culture is feasible for the industrial production of plant-derived fine chemicals. Due to low or no productivity of the desired compounds the economy is only in a few cases favorable. Various approaches are studied to increase yields, these encompass screening and selection of high producing cell lines, media optimization, elicitation, culturing of differentiated cells (organ cultures), immobilization. In recent years metabolic engineering has opened a new promising perspectives for improved production in a plant or plant cell culture.

genetic modification metabolic engineering phytochemicals plant cell biotechnology plant cell culture plant secondary metabolism 

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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • R. Verpoorte
    • 1
  • R. van der Heijden
    • 1
  • H.J.G. ten Hoopen
    • 2
  • J. Memelink
    • 3
  1. 1.Division of Pharmacognosy, Leiden/Amsterdam Center for Drug ResearchLeiden UniversityLeidenThe Netherlands
  2. 2.Department of Biochemical EngineeringDelft University of TechnologyDelftThe Netherlands
  3. 3.Institute of Molecular Plant SciencesLeiden UniversityLeidenThe Netherlands

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