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Biotechnology Letters

, Volume 21, Issue 3, pp 253–257 | Cite as

Production of statins by filamentous fungi

  • Matilde Manzoni
  • Silvia Bergomi
  • Manuela Rollini
  • Valeria Cavazzoni
Article

Abstract

Several Monascus and Aspergillus strains were screened for statins production. Lovastatin, monacolin J, pravastatin and mevastatin were produced, with higher yields from the A. terreus strains than from Monascus species. Of all the strains investigated M. paxii AM12M, an isolated spontaneous mutant, yielded 127 mg lovastatin/l and 53 mg pravastatin/l at 21 days, and 18 mg pravastatin/l at 16 days employing a whole soybean flour medium; A. terreus BST yielded 230 mg lovastatin/l and 118 mg pravastatin/l at 14 days employing a defatted soybean flour medium. Statins recovery showed that pravastatin was, in both strains, mostly found in both the mycelium and the culture filtrate, while lovastatin remained closely associated (83%) to the A. terreus mycelium or was mainly released into the culture filtrate (64%) of M. paxii culture.

Aspergillus Monascus statins production statins recovery 

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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Matilde Manzoni
    • 1
  • Silvia Bergomi
    • 1
  • Manuela Rollini
    • 1
  • Valeria Cavazzoni
    • 1
  1. 1.Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche, Sezione di Microbiologia IndustriaUniversità degli StudiMilanoItaly

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