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Journal of Bioenergetics and Biomembranes

, Volume 31, Issue 4, pp 335–345 | Cite as

Progress on the Mitochondrial Permeability Transition Pore: Regulation by Complex I and Ubiquinone Analogs

  • Eric Fontaine
  • Paolo Bernardi
Article

Abstract

This review summarizes recent progress on the regulation of the mitochondrial permeabilitytransition pore, an inner membrane channel that may play a role in cell death. We brieflycover its key control points as emerged over the last few years from studies on isolatedmitochondria; and describe in some detail our recent results indicating that the pore is modulatedby the respiratory chain complex I and can be specifically blocked by selected ubiquinoneanalogs. We discuss the potential relevance of these findings for the structural definition ofthe permeability transition pore and illustrate the pharmacological perspectives they offer indiseases where mitochondrial dysfunction is suspected to play a key role.

Mitochondrial channels respiratory chain complex I ubiquinone cell death disease aging 

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Copyright information

© Plenum Publishing Corporation 1999

Authors and Affiliations

  • Eric Fontaine
    • 1
  • Paolo Bernardi
    • 2
    • 3
  1. 1.Laboratoire de Bioénergétique Fondamentale et AppliquéeUniversité J. FourierGrenobleFrance
  2. 2.Consiglio Nazionale delle Ricerche Unit for the Study of Biomembranes and the Laboratory of Biophysics and Membrane Biology, Department of Biomedical SciencesUniversity of Padova Medical SchoolPadovaItaly
  3. 3.Dipartimento di Scienze Biomediche SperimentaliPadovaItaly

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