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Digestive Diseases and Sciences

, Volume 45, Issue 2, pp 252–257 | Cite as

Gastric Emptying and Dyspeptic Symptoms in Patients with Nonautoimmune Fundic Atrophic Gastritis

  • Cesare Tosetti
  • Vincenzo Stanghellini
  • Antonio Tucci
  • Loris Poli
  • Beatrice Salvioli
  • Guido Biasco
  • Giovanni Francesco Paparo
  • Maurizio Levorato
  • Roberto Corinaldesi
Article

Abstract

Our aim was to evaluate the relationship between gastric emptying and demographic, clinical, histological, and secretory features in patients with nonautoimmune fundic atrophic gastritis. Only 31% of 45 patients with fundic atrophic gastritis presented with achlorhydria. Scintigraphic gastric emptying of solids was delayed compared to healthy controls. Patients with achlorhydria showed gastric emptying rates lower than those with preserved acid secretion. Significant, but weak, correlations were observed between emptying rates and both peak acid output (Rs = 0.33) and serum gastrin levels (Rs = −0.36), but not with grading of mucosal atrophy. No symptom differences were observed between patients with or without achlorhydria, but a weak correlation was detected between peak acid output and the severity of epigastric pain (Rs = 0.40). In conclusion, patients with fundic atrophic gastritis present delayed gastric emptying that is weakly related to the reduction of the acid secretion and the raising of serum gastrin levels rather than to the severity of the atrophy.

gastric emptying dyspepsia atrophic gastritis acid secretion gastrin 

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Copyright information

© Plenum Publishing Corporation 2000

Authors and Affiliations

  • Cesare Tosetti
    • 1
    • 2
  • Vincenzo Stanghellini
    • 1
    • 2
  • Antonio Tucci
    • 1
    • 2
  • Loris Poli
    • 1
    • 2
  • Beatrice Salvioli
    • 1
    • 2
  • Guido Biasco
    • 1
    • 2
  • Giovanni Francesco Paparo
    • 1
    • 2
  • Maurizio Levorato
    • 1
    • 2
  • Roberto Corinaldesi
    • 1
    • 2
  1. 1.Department of Internal Medicine and GastroenterologyUniversity of BolognaItaly
  2. 2.Department of Nuclear MedicineS. Orsola-Malpighi HospitalBolognaItaly

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