Genetica

, Volume 108, Issue 3, pp 259–262 | Cite as

Molecular Cloning and Chromosomal Localization of Human Salt-Tolerant Protein

  • Emiko Tsuji
  • Yuji Tsuji

Abstract

We have isolated a novel human cDNA coding for human salt-tolerant protein (HSTP), that is a homologue of the rat salt-tolerant protein (STP) and may contribute to salt-induced hypertension by modulating renal cation transport. The nucleotide sequence (1988 bp) of the HSTP cDNA contains an open reading frame encoding a polypeptide comprising 545 amino acids, two residues fewer than the rat STP cDNA. The predicted amino acid sequence exhibits 92% identity to that of the rat protein. HSTP contains predicted coiled-coil domains and Src Homology 3 domain, and shows a high degree of identity to CIP4 (Cdc42 target protein) and human Trip 10 (thyroid-hormone receptor interacting protein). We have mapped the HSTPgene to human chromosome 19 by fluorescence in situhybridization.

hypertension salt sensitivity SH3 domain 

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Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Emiko Tsuji
    • 1
  • Yuji Tsuji
    • 2
  1. 1.Second Department of Internal MedicineFukuoka UniversityFukuokaJapan
  2. 2.Department of Urology, School of MedicineFukuoka UniversityFukuokaJapan

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