Bulletin of Experimental Biology and Medicine

, Volume 130, Issue 11, pp 1038–1040 | Cite as

Cardiotropic effects of met-enkephalin and somatostatin under conditions of neurotensin receptor blockade

  • O. E. Osadchii
  • E. K. Totskaya
  • V. M. Pokrovskii
  • A. N. Kurzanov
Physiology
  • 15 Downloads

Abstract

Pretreatment with the neurotensin receptor antagonist decreased the severity and time of Metenkephalin-induced inhibition of vagal chronotropic effects in cats. The opiate receptor antagonist naloxone produced a delayed inhibitory effect on the synchronizing component of the vagal chronotropic effect under conditions of neurotensin receptor blockade. Cardiotropic effects of somatostatin remained unchanged during neurotensin receptor blockade. These data indicate one-way and two-way interactions between peptides modulating parasympathetic cardiac regulation.

Key Words

neurotensin Met-enkephalin somatostatin cardiac regulation 

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References

  1. 1.
    E. V. Montsevichyute-Eringene,Pat. Fiziol., No. 4, 71–78 (1964).Google Scholar
  2. 2.
    O. E. Osadchii and V. M. Pokrovskii,Ros. Fiziol. Zh.,85, No. 5, 628–636 (1999).Google Scholar
  3. 3.
    O. E. Osadchii and V. M. Pokrovskii,Ibid.,,85, No. 8, 1051–1059 (1999).Google Scholar
  4. 4.
    O. E. Osadchii, V. M. Pokrovskii, and E. K. Totskaya,Mechanisms of Functioning of Visceral Systems [in Russian], St. Petersburg (1999), p. 243.Google Scholar
  5. 5.
    G. Campbell, I. L. Gibbins, J. L. Morris,et al., Neuroscience,7, No. 9, 2013–2023 (1982).PubMedCrossRefGoogle Scholar
  6. 6.
    T. Hokfelt,Neuron,7, 867–879 (1991).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 2000

Authors and Affiliations

  • O. E. Osadchii
    • 1
  • E. K. Totskaya
    • 1
  • V. M. Pokrovskii
    • 1
  • A. N. Kurzanov
    • 1
  1. 1.Department of Normal PhysiologyKuban Medical AcademyKrasnodar

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