Antonie van Leeuwenhoek

, Volume 76, Issue 1–4, pp 383–389

Immunomodulatory function of lactic acid bacteria

  • Hisako Yasui
  • Kan Shida
  • Takeshi Matsuzaki
  • Teruo Yokokura


Using mice, we found that oral administration of Bifidobacterium breve YIT4064 (B. breve) activated the humoral immune system, augmented anti-rotavirus IgA production or anti-influenza virus (IFV) IgG production and protected against rotavirus infection or influenza infection, respectively. Furthermore, when the B. breve was given to infants from an infant home, there was a significant reduction of the frequency of rotavirus shedding in stool samples during the administration of the bacteria. It was also found, again using mice, that oral administration of Lactobacillus casei strain Shirota (LcS) stimulated type 1 helper T (Th1) cells, activated the cellular immune system and inhibited incidence of tumors and IgE production. These results demonstrated that these two strains of lactic acid bacteria modulated the different immune systems each in its own way and prevented against various diseases.

Bifidobacterium breve Lactobacillus casei immunomodulation IgG IgA IgE prevention against diseases rotavirus infection influenza virus infection tumor 


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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Hisako Yasui
    • 1
  • Kan Shida
    • 1
  • Takeshi Matsuzaki
    • 1
  • Teruo Yokokura
    • 1
  1. 1.Yakult Central Institute for Microbiological ResearchTokyoJapan

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