Naturally Acquired Immunity as an Element in Strategies for the Control of Ticks on Livestock

  • John E. George
Natural Resistance to Ticks


Risk-benefit considerations have stimulated efforts to develop technology to overcome the limitations of procedures that place excessive reliance on the use of acaricides for the control of ticks affecting cattle. One of the alternatives to acaricides is the selection and use of breeds of cattle with a natural propensity for developing acquired resistance to ticks. The literature on aspects of the modes of expression and mechanisms of resistance of cattle to ticks, is reviewed along with information on the successful efforts in Australia to develop productive Bos indicus × Bos taurus breeds with the ability to develop high levels of resistance. The use of cattle resistant to ticks is discussed in relation to other factors that should be considered in the design of a programme for tick control.

Key Words

Acquired immunity resistance tick control Boophilus microplus heritable cattle Ixodes holocyclus Hyalomma anatolicum Amblyomma americanum 


Les considérations des risques et des avantages ont commencé les efforts pour développer une technologie qui surmonterait les restrictions des procédures qui comptent trop sur l’utilisation des acaricides pour contrôler les coutils qui affectent le bétail. Une autre alternative au lieu des acaricides est la sélection et l’utilisation d’un élevage de bétail qui a une inclination naturelle pour développer une résistance acquise contre les coutils. La littérature actuelle est analysée à propos des aspects et des modes d’expression et des mécanismes de résistance du bétail contre les coutils. Il y a aussi une analyse de l’information à propos des efforts qui ont eu du succès en Australie pour développer les élévages Bos indicus × Bos taurus. Ces élévages sont très productifs et possèdent la capacité de développer une grande résistance contre les coutils. On discute l’utilisation du bétail qui résiste les coutils à propos des autres facteurs qui sont importants et qui mèritent considération en développant une programme de contrôle contre les coutils.


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  1. Allen J. R., Doube B. M., Kemp D. H. (1977) Histology of bovine skin reactions to Ixodes holocyclus Neumann. Can. J. comp. Med. 41, 26–35.PubMedPubMedCentralGoogle Scholar
  2. Allen J. R. and Kemp D. H. (1982) Observations on the behaviour of Dermacentor andersoni larvae. Parasitology 84, 195–204.CrossRefGoogle Scholar
  3. Allen J. R. and Nelson W. A. (1982) Immunological responses to ectoparasites. In Fortschritte der Zoologie, Band 27. Zbl. Bakt. Suppl. 12: Immune Reactions to Parasites, pp. 169–180. Gustav Fischer Verlag, Stuttgart.Google Scholar
  4. Alexander G. I., Reason G. K. and Clark C. H. (1984a) The development of the Australian Friesian Sahiwal, a tick resistant dairy breed. World Anim. Rev. July–September, 27–34.Google Scholar
  5. Alexander G. L, Reason G. K., Gale G. M. R. and Clark C. H. (1984b) The performance of the Australian Freisian Sahiwal cattle. World Anim. Rev. October–December, 13–52.Google Scholar
  6. Bennett G. F. (1969) Boophilus microplus (Acarina: Ixodidae): Experimental infestations on cattle restrained from grooming. Exp. Parasitol. 26, 323–328.CrossRefGoogle Scholar
  7. Binta M. G. and Cunningham M. P. (1984) Cutaneous responses of cattle to extracts from Rhipicephalus appendiculatus larvae. Vet. Parasitol. 15, 67–73.CrossRefGoogle Scholar
  8. Binta M. G., Cunningham M. P. and Mushi E. Z. (1984a) Effect of some drugs on the skin response of tick-resistant cattle to an allergenic extract of larval Rhipicephalus appendicular. Vet. Res. Com. 8, 275–282.CrossRefGoogle Scholar
  9. Binta M. G., Cunningham M. P. and Rurangirwa F. R. (1984b) Bovine homocytotropic antibody in the sera of cattle resistant to infestation with Rhipicephalus appendicular. Vet. Res. Com. 8, 269–274.CrossRefGoogle Scholar
  10. Brossard M. (1976) Relations immunologiques entre Bovins et Tiques, plus particulierement entre Bovins et Boophilus microplus. Acta Tropica 33, 15–36.PubMedPubMedCentralGoogle Scholar
  11. Brown S. J., Barker, R. W. and Askenase P. W. (1984) Bovine resistance to Amblyomma americanum ticks: An acquired immune response characterized by cutaneous basophil infiltrates. Vet. Parasitol. 16, 147–165.CrossRefGoogle Scholar
  12. de Castro J.J., Newson R.M. and Herbert I.V.(1989) Resistance in cattle against Rhipicephalus appendiculatus with an assessment of cross-resistance to R. pulchellus (Acari: Ixodidae). Exp. Appl. Acarol. 6, 237–244.CrossRefGoogle Scholar
  13. Doube B.M. and Kemp D.H. (1975) Paralysis of cattle by Ixodes holocyclus Neumann. Aust. J. agric. Res. 26, 635–640.CrossRefGoogle Scholar
  14. Doube B. M. and Wharton R. H. (1980) The effect of locality, breed and previous tick experience on seasonal changes in the resistance of cattle to Boophilus microplus (Ixodoidea: Ixodidae). Experientia 36, 1178–1179.CrossRefGoogle Scholar
  15. George J. E., Osbum R. L. and Wikel S. K. (1985) Acquisition and expression of resistance by Bos indicus and Bos indicus × Bos taurus calves to Amblyomma americanum infestations. J. Parasitol. 71, 174–182.CrossRefGoogle Scholar
  16. Gill H. S. (1986) Kinetics of mast cell, basophil and eosinophil populations at Hyalomma anatolicum anatolicum feeding sites on cattle and the acquisition of resistance. Parasitology 93, 305–313.CrossRefGoogle Scholar
  17. Gladney W. J., Graham O. H., Trevino J. L. and Ernst S. E. (1973) Boophilus annulatus: Effect of host nutrition on development of female ticks. J. Med. Entomol. 10, 123–130.CrossRefGoogle Scholar
  18. Gomes A., Honer M. R., Schenk M. A. M. and Curvo J. B. E. (1989) Populations of the cattle tick (Boophilus microplus) on purebred Nellore, Ibage and Nellore × European crossbreds in the Brazilian savanna. Trop. Anim. Hlth. Prod. 21, 20–24.CrossRefGoogle Scholar
  19. Granado A., Gutierrez M., Saez C. and Figueredo J. M. (1987) Resistencia genetica a la infestacion de garrapatas in dosniveles de cruzamiento Hostein-Cebu. Rvta. Cub. Cienc. Vet. 18, 171–180.Google Scholar
  20. Hayman R. H. (1972) Bos indicus and Bos taurus crossbred dairy cattle in Australia: I. Crossbreeding with selection among filial generations. Aust. J. agric. Res. 23, 519–532.CrossRefGoogle Scholar
  21. Hewetson R. W. (1971) Resistance by cattle to the cattle tick, Boophilus micro plus. III. The development of resistance to experimental infestations by purebred Sahiwal and Australian Illawarra Shorthorn cattle. Aust. J. agric. Res. 22, 331–342.CrossRefGoogle Scholar
  22. Johnston T. H. and Bancroft M. J. (1918) A tick resistant condition in cattle. Proc. R. Soc. Qd. 30, 219–317.Google Scholar
  23. Kaiser M. N., Sutherst R. W. and Bourne A. S. (1982) Relationship between ticks and Zebu cattle in southern Uganda. Trop. Anim. Hlth. Prod. 14, 63–74.CrossRefGoogle Scholar
  24. Kaiser M. N., Sutherst R. W., Bourne A. S., Gorissen L. and Floyd R. B. (1988) Population dynamics of ticks on Ankole cattle in five ecological zones in Burundi and strategies for their control. Prev. Vet. Med. 6, 199–222.CrossRefGoogle Scholar
  25. Kemp D. H., Koudstaal D., Roberts J. A. and Kerr J. D. (1976) Boophilus microplus: the effect of host resistance on larval attachments, and growth. Parasitology 73, 123–136.CrossRefGoogle Scholar
  26. Kemp D.H. and Bourne A. (1980) Boophilus microplus: The effect of histaine on the attachment of cattle-tick larvae-studies in vivo and in vitro. Parasitology 80, 487–496.CrossRefGoogle Scholar
  27. Koudstaal D., Kemp D. H. and Ken J. D. (1978) Boophilus microplus: Rejection of larvae from British breed cattle. Parasitology 76, 379–386.CrossRefGoogle Scholar
  28. Latif A. A. (1984a) Resistance to natural tick infestations in different breeds of cattle in the Sudan. Insect Sci. Applic. 5, 95–97.Google Scholar
  29. Latif A. A. (1984b) Resistance to Hyalomma anatolicum anatolicum Koch (1844) and Rhipicephalus evertsi Neumann (1897) (Ixodoidea: Ixodidae) by cattle in the Sudan. Insect Sci. Applic. 5, 509–511.Google Scholar
  30. Lemos A.M., Teodoro R.L., Oliveira G.P., Madalena F. E. (1985) Comparative performance of six Holstein-Friesian Guzera grades in Brazil. 3. Burdens of Boophilus microplus under field conditions. Anim. Prod. 41, 187–191.CrossRefGoogle Scholar
  31. Mangold A. J., Aguirre D. H., Bermudez A. C, Kuhne G. I. and Guglielmone A. A. (1986) Infestaciones naturales de bovinos Hereford, Criollos y Nelore con Boophilus microplus. Vet. Arg. 3, 238–246.Google Scholar
  32. Matthewson M. D. (1984) The future of tick control: A review of the chemical and non-chemical options. Prev. Vet. Med. 2, 559–568.CrossRefGoogle Scholar
  33. Mohler J. R. (1906) Texas or tick fever and its prevention. Farmers’ Bull. No. 258. US Department of Agriculture, Washington, DC.Google Scholar
  34. Norton G. A., Sutherst R. W. and Maywald G. F. (1983) A framework for integrating control methods against the cattle tick, Boophilus microplus in Australia. J. Appl. Ecol. 20, 489–505.CrossRefGoogle Scholar
  35. Norval R. A. I. (1978) Repeated feedings of Amblyomma hebraeum (Acarina: Ixodidae) immatures on laboratory hosts. Host effects on tick yield, engorged weight and engorgement period. J. Parasitol. 64, 910–917.CrossRefGoogle Scholar
  36. Norval R. A. I. (1983) Arguments against intensive dipping. Zimbabwe Vet. J. 14, 19–25.Google Scholar
  37. Norval R. A. I., Floyd R. B. and Kerr J. D. (1988) Ability of adults of Amblyomma hebraeum (Acarina: Ixodidae) to feed repeatedly on sheep and cattle. Vet. Parasitol. 29, 351–355.CrossRefGoogle Scholar
  38. O’Kelly J. C. and Seifert G. W. (1969) Relationships between resistance to Boophilus microplus, nutritional status, and blood composition in Shorthorn × Hereford cattle. Aust. J. biol. Sci. 22, 1497–1506.CrossRefGoogle Scholar
  39. O’Kelly J. C. and Spiers W. G. (1976) Resistance to Boophilus microplus (Canestrini) in genetically different types of calves in early life. J. Parasitol. 2, 312–317.CrossRefGoogle Scholar
  40. O’Kelly J. C. (1984) Decreased resistance of Bos taurus cattle on a diet supplemented with whole cotton seed to the tick Boophilus microplus (Canestrini). Vet. Parasitol. 15, 151–157.CrossRefGoogle Scholar
  41. Pegram R. G., Lemche J., Chizyuka H. G. B., Sutherst R. W., Floyd R. B., Kerr J. D. and McCosker P. J. (1989) Ecological aspects of cattle tick control in central Zambia. Med. Vet. Entomol. 3, 307–312.CrossRefGoogle Scholar
  42. Reich C. I. and Zorzopulos J. (1980) Boophilus microplus: Cattle antienzymes to larval phosphomonoesterases. Exp. Parasitol. 50, 272–277.CrossRefGoogle Scholar
  43. Riek R. F. (1962) Studies on the reactions of animals to infestation with ticks. VI. Resistance of cattle to infestation with the tick Boophilus microplus (Canestrini). Aust. J. agric. Res. 13, 532–550.CrossRefGoogle Scholar
  44. Roberts J. A. (1968a) Acquisition by the host of resistance to the cattle tick, Boophilus microplus (Canestrini). J. Parasitol. 54, 657–662.CrossRefGoogle Scholar
  45. Roberts J.A. (1968b) Resistance of cattle to the tick Boophilus microplus (Canestrini). II. Stages of the life cycle of the parasite against which resistance is manifest. J. Parasitol. 54, 667–673.CrossRefGoogle Scholar
  46. Roberts J.A. and Kerr J.D. (1976) Boophilus microplus: Passive transfer of resistance in cattle. J. Parasitol. 62, 485–488.CrossRefGoogle Scholar
  47. Schleger A. V., Lincoln D. T., McKenna R. V., Kemp D. H. and Roberts J. A. (1976) Boophilus microplus: Cellularresponses to larval attachment and their relationship to host resistance. Aust. J. Biol. Sci. 29, 499–512.CrossRefGoogle Scholar
  48. Schleger A. V., Lincoln D.T. and Kemp D.H. (1981) A putative role for eosinophils in tick rejection. Experientia 37, 49–50.CrossRefGoogle Scholar
  49. Seifert G. W. (1971) Variations between and within breeds of cattle in resistance to field infestations of the cattle tick Boophilus microplus. Aust. J. agric. Res. 22, 159–168.CrossRefGoogle Scholar
  50. Seifert G. W. (1984) Selection of beef cattle in northern Australia for resistance to the cattle tick (Boophilus microplus): Rescaich and application. Prev. Vet. Med. 2, 553–558.CrossRefGoogle Scholar
  51. Strother G. R., Burns E. C, and Smart L. I. (1974) Resistance of purebred Brahman, Hereford, and Brahman × Hereford crossbred cattle to the lone star tick, Amblyomma americanum (Acarina: Ixodidae). J. Med. Entomol. 5, 559–563.Google Scholar
  52. Sutherst R. W., Roberts J. A. and Wagland B. M. (1979a) Resistance in cattle to Haemaphysalis (kaiseriana) longicornis. Int. J. Parasitol. 9, 183–188.CrossRefGoogle Scholar
  53. Sutherst R. W., Wharton R. H., Cook I. M., Sutherland I. D. and Bourne A. S. (1979b) Long-term population studies on the cattle tick (Boophilus microplus) on untreated cattle selected for different levels of tick resistance. Aust. J. agric. Res. 30, 353–368.CrossRefGoogle Scholar
  54. Sutherst R. W. (1981) Is the Australian pest management approach to tick control relevant to Africa? In Tick Biology and Control (Edited by Whitehead G. B. and Gibson J. D.), pp. 79–85. TickResearch Unit, Grahamstown, South Africa.Google Scholar
  55. Tatchell R. J. and Moorhouse D. E. (1968) The feeding processes of the cattle tick Boophilus microplus (Canestrini). II. The sequence of host-tissue changes. Parasitology 58, 441–459.CrossRefGoogle Scholar
  56. Tatchell R. J. (1987) Interactions between ticks and their hosts. Int. J. Parasitol. 17, 597–605.CrossRefGoogle Scholar
  57. Utech K. B. W., Seifert G. W. and Wharton R. H. (1978a) Breeding Australian Illawarra Shorthorn cattle for resistance to Boophilus microplus. I. Factors affecting resistance. Aust. J. agric. Res. 29, 411–422.CrossRefGoogle Scholar
  58. Utech K. B. W. and Wharton R. H. (1978b) Resistance to Boophilus microplus in different breeds of cattle. Aust. J. agric. Res. 29, 885–895.CrossRefGoogle Scholar
  59. Utech K.B.W. and Wharton R.H. (1982) Breeding for resistance to Boophilus microplus in Australian Illawarra Shorthorn and Brahman × Australian Illawarra Shorthorn cattle. Aust. Vet. J. 58, 41–46.CrossRefGoogle Scholar
  60. Wagland B. M. (1975) Host resistance to cattle tick (Boophilus microplus) in Brahman (Bos indicus) cattle. I. Responses of previously unexposed cattle to four infestations with 20,000 larvae. Aust. J. agric. Res. 26, 1073–1080.CrossRefGoogle Scholar
  61. Wagland B. M. (1978) Host resistance to cattle tick (Boophilus microplus) in Brahman (Bos indicus) cattle. II. The dynamics of resistance in previously unexposed and exposed cattle. Aust. J. agric. Res. 29, 395–400.CrossRefGoogle Scholar
  62. Wagland B. M. (1979) Host resistance to cattle tick (Boophilus microplus) in Brahman (Bos indicus) cattle. IV. Ages of ticks rejected. Aust. J. agric. Res. 30, 211–218.CrossRefGoogle Scholar
  63. Waters K. S. (1982) Controlling cattle ticks by breeding and selection in north Queensland. Queensland agric. J. July–August, 200–202.Google Scholar
  64. Waters K. S. (1985) A north Queensland field exercise in selection for tick resistance. Queensland agric. J. May–June 161–162.Google Scholar
  65. Wellcome Research Organization (1976) Cattle Tick Control, p. 3. Clunbaury Cottrell Press, Berkhamsted.Google Scholar
  66. Wharton R. H., Harley K. L. S., Wilkinson P. R., Utech K. B. and Kelley B. M. (1969) A comparison of cattle tick control by pasture spelling planned dipping, and tick-resistant cattle. Aust. J. agric. Res. 20, 783–797.CrossRefGoogle Scholar
  67. Wharton R. H., Utech K. B. W. and Turner H. G. (1970) Resistance to the cattle tick, Boophilus microplus in a herd of Australian Illawarra Shorthorn cattle: Its assessment and heritability. Aust. J. agric. Res. 21, 163–181.CrossRefGoogle Scholar
  68. Wharton R. H. and Norris K. R. (1980) Control of parasitic arthropods. Vet. Parasitology 6, 135–164.CrossRefGoogle Scholar
  69. Wikel S. K. (1982) Histamine content of tick attachment sites and the effects of H1 and H2 histamine antagonists on the expression of resistance. Ann. Trop. Med. Parasitol. 76, 179–185.CrossRefGoogle Scholar
  70. Willadsen P., Williams P. G., Roberts J. A. and Kerr J. D. (1978) Responses of cattle to allergens from Boophilus microplus. Parasitology 8, 89–95.Google Scholar
  71. Willadsen P., Wood G. M. and Riding G. A. (1979) The relation between skin histamine concentration, histamine sensitivity, and the resistance of cattle to the tick, Boophilus microplus. Z. Parasitenk. 59, 87–93.CrossRefGoogle Scholar
  72. Willadsen P. (1980) Immunity to ticks. Adv. Parasitol. 18, 293–313.CrossRefGoogle Scholar
  73. Willadsen P. and McKenna R. V. (1983) Binding of antigens to tissues: The example of Boophilus microplus and bovine skin. Int. J. Parasitol. 13, 593–598.CrossRefGoogle Scholar
  74. Wilkinson P. R. (1955) Observations on infestations of undipped cattle of British breeds with the cattle tick, Boophilus microplus (Canestrini). Aust. J. agric. Res. 6, 655–656.CrossRefGoogle Scholar

Copyright information

© ICIPE 1992

Authors and Affiliations

  • John E. George
    • 1
  1. 1.US Department of Agriculture, Agricultural Research ServiceKnipling-Bushland US Livestock Insects Research LaboratoryKerrvilleUSA

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