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Antiparasitic Compounds from East African Plants: Isolation and Biological Activity of Anonaine, Matricarianol, Canthin-6-One and Caryophyllene Oxide

  • F. Bettarini
  • G. E. Borgonovi
  • T. Fiorani
  • I. Gagliardi
  • V. Caprioli
  • P. Massardo
  • J. I. J. Ogoche
  • A. Hassanali
  • E. Nyandat
  • A. Chapya
Research Article

Abstract

Five natural compounds possessing antiparasitic activity were isolated from East African plants and tested, together with some semisynthetic derivatives, against micro-organisms and arthropods of agricultural interest. Anonaine (1), from Annona squamosa, canthin-6-one (8) and 5-methoxycanthin-6-one (9), from Fagaropsis angolensis, showed fungicidal activity. E,Z-matricarianol (4), from Hoehnelia vernonioides was fungicidal, insecticidal and acarlcldal. Caryophyllene oxide (12), isolated from Uvaria sp., turned out to be insecticidal and antifeedant. Canthin-6-one (8) and its dihydroderivative 11 were the most effective antimicrobial compounds tested. The possibility of using some of the isolated compounds as leads for new synthetic chemicals is discussed.

Key Words

Antiparasitic activity fungicidal activity insecticidal activity anonaine Annona squamosa canthin-6-one Fagaropsis angolensis Zanthoxylum usambarensis E,Z-matricarianol Hoehnelia vernonioides caryophyllene oxide Uvaria sp 

Résumé

Cinq produits naturels ayant de l’activité antiparasitaire étaient isolés de plantes de l’Afrique Orientale et évalués, avec quelques dérivés semisynthétiques, contre des microrganismes et des arthropodes d’intérêt agricole. L’anonaine (1), isolée del’ Annona squamosa, le cantin-6-one (8) et le 5-methoxycantin-6-one (9), isolés de la Fagaropsis angolensis, montraient de l’activité fongicide. L’ E,Z-matricarianol (4), isolé de l’Hoehnelia vernonioides, se revelait fongicide, insecticide et acaricide. L’époxide de B-caryophyllène (12), isolé de l’ Uvria sp., se révélait insecticide et antiappetant. Le cantin-6-one (8) et son dihidroderivé 11 étaient les plus actifs parmi les produits antimicrobiens évalués. On discute la possibilité d’utiliser quelques-uns des produits isolés comme souches de nouveaux produits synthétiques.

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Copyright information

© ICIPE 1993

Authors and Affiliations

  • F. Bettarini
    • 1
  • G. E. Borgonovi
    • 1
  • T. Fiorani
    • 1
  • I. Gagliardi
    • 1
  • V. Caprioli
    • 2
  • P. Massardo
    • 2
  • J. I. J. Ogoche
    • 3
  • A. Hassanali
    • 3
  • E. Nyandat
    • 3
  • A. Chapya
    • 3
  1. 1.Istituto Guido Donegani S.p.A.Enimont GroupNovaraItaly
  2. 2.Agrimont S.r.l., Ricerca FitofarmaciEnimont GroupNovaraItaly
  3. 3.The International Centre of Insect Physiology and EcologyNairobiKenya

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