Effect of Some Benzyl-1,3-Benzodioxole Analogs on Reproduction in the Mediterranean Fruit Fly, Ceratitis capitata (Wiedemann)

  • F. Chang
  • C. L. Hsu
  • L. Jurd
Research Article


Seven benzyl-1,3-benzodioxole analogs were tested for possible effects on reproduction in females of the Mediterranean fruit fly. Single topical doses of J2581 (5-ethoxy-6-[4-methoxyphenyl]methyl-1,3-benzodioxole) and J3263 (5-methoxy-6-(1-[4-ethoxyphenyl]ethyl)-1,3-benzodioxole) were found to cause a temporary delay in ovarian growth in female medflies by 9 and 13 days respectively when compared to acetone-treated controls. Continued exposure of the analogs at the target site(s) appears to be necessary for more permanent effects. Nurse cell development appears not to be affected, but oocyte growth and subsequent egg production and egg hatch were significantly reduced. Methoprene treatment appeared to obviate the effect of J2581 in arresting ovarian growth.

Key Words

Benzyl-1,3-benzodioxoles reproduction medfly ovary chemosterilant topical application methoprene 


Sept analogues de benzyl-1, 3-benzodioxole verifièrent pour des effets possibles sur la reproduction des femelles de [Diptera: Tephritidae]. Des doses topiques singulières de J2581 (5-ethoxy-6-[4-methoxyphenyl]methyl-1, 3-benzodioxole) trouvèrent à causer un délai temporaire dans le développement ovarien des familles de [Diptera: Tephritidae] par 9 et 13 jours, respectivement, en comparaison des contrôles qui traitèrent avec l’acétone. Il semble que l’exposition continuée des analogues aux sites sélectifs fût nécessaire pour des effets plus permanents. Il ne semble pas que le développement de “nurse cell” fût affecté, mais le développement de l’oocyte et la production d’oeuf subséquent et la couvée d’oeuf réduirent significativement. Le traitement methoprene concomitant avec ou 3 jours après le traitement benzodioxole initial obvia à ou accéléra le développement ovarien, respectivement.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Brookes G. T., Pratt G. E., Mace D. W. and Cocks J. A. (1985) Inhibition of juvenile hormone biosynthesis in corpora allata of the cockroach Periplanela amehcana (L.) in vitro. Pestic. Sci. 16, 132–142.CrossRefGoogle Scholar
  2. Chang S. C., Borkovec A. B. and Demilo A. B. (1980) Effects of substituted benzylphenols on reproduction of house flies. J. Econ. Ent. 73, 745–747.CrossRefGoogle Scholar
  3. Chang F., Hsu C. L., Jurd L. and Williamson D. L. (1984) Effect of precocene and benzyl-1,3-benzodioxole derivatives on sex attractancy in the Mediterranean fruit fly (Diptera: Tephritidae). Ann. ent. Soc. Am. 77, 147–151.CrossRefGoogle Scholar
  4. De Loof A., Van Mellaert H., and Jurd L. (1982) Two new compounds with anti-juvenile hormone activity as shown by the Galleria bioassay. Gen. Comp. Endocrinol. 46, 377.Google Scholar
  5. Flint H. M., Jurd L. and Merkle J. (1980) Pink bollworm: Sterilizing effects of benzylphenols and benzyl-1,3-benzodioxoles. J. econ. Ent. 73, 710–714.CrossRefGoogle Scholar
  6. Fuchs M. S. and Kang S. H. (1981) Ecdysone and mosquito vitellogenesis: A critical appraisal. Insect Biochem. 11, 627–633.CrossRefGoogle Scholar
  7. Jurd L., Stevens K. and Manners G. D. (1972) Quinonoid constituents of Dalbergia retusa heartwood. Phytochem. 11, 3287–3292.CrossRefGoogle Scholar
  8. Jurd L., Fye R. L. and Morgan J., Jr. (1979) New types of insect chemosterilants. Benzylphenols and benzyl-1,3-benzodioxole derivatives as additives to housefly diet. J. Agric. Food Chem. 27, 1007–1016.CrossRefGoogle Scholar
  9. Jurd L. and Manners G. D. (1980) Wood extractives as models for the development of new types of pest control agents. J. Agric. Food Chem. 28, 183–188.CrossRefGoogle Scholar
  10. Langley P. A., Trewern M. A. and Jurd L. (1982) Sterilizing effects of benzyl-1,3-benzodioxoles on the tsetse fly Glossina morsitans morsitans. Bull. ent. Res. 72, 473–481.CrossRefGoogle Scholar
  11. Rawlins S. C., Jurd L. and Snow J. W. (1979) Antifertility effects of benzylphenols and benzyl-1,3-benzodioxoles on screwworm flies. J. econ. Ent. 72, 674–677.CrossRefGoogle Scholar
  12. Rawlins S. C. and Jurd L. (1981) Influence of the mode of administration of benzylphenols and benzyl-1,3-benzodioxoles on screwworm fertility. J. Econ. Ent. 74, 215–217.CrossRefGoogle Scholar
  13. Riddiford L. M., Osir E., Fittinghoff C. and Green J. M. (1987) Methoprene and JH I may have different receptor sites in nuclei of Manduca sexta larval epidermis. Insect Biochem. (In Press).Google Scholar
  14. Tanaka N., Steiner L. F. Ohinata K. and Okamoto R. (1969) Low-cost larval rearing medium for mass production of oriental and Mediterranean fruit flies. J. econ. Ent. 62, 967–968.CrossRefGoogle Scholar
  15. Van Mellaert H. V., De Loof A. and Jurd L. (1983a) Physiological effects of a benzyl-1,3-benzodioxole chemo-sterilant on Sarcophaga bullata. Pestic. Biochem. Physiol. 20, 124–130.CrossRefGoogle Scholar
  16. Van Mellaert H. V., De Loof A. and Jurd L. (1983b) Antijuvenile hormone effects on newly described chemosterilants: Benzyl-1,3-benzodioxoles and benzylphenols. Ent. Exp. & Appl. 33, 83–88.CrossRefGoogle Scholar

Copyright information

© ICIPE 1988

Authors and Affiliations

  • F. Chang
    • 1
  • C. L. Hsu
    • 1
  • L. Jurd
    • 1
    • 2
  1. 1.Department of EntomologyUniversity of HawaiiHonoluluUSA
  2. 2.Western Regional Research CenterARS, USDABerkeleyUSA

Personalised recommendations