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Ecological and Physiological Factors in the Cyclic Transmission of African Trypanosomiasis

  • F. L. Lambrecht
Article

Abstract

The cyclic transmission of African trypanosomes is subject to the successful passage through successive ‘biological barriers’ associated with the ecology and physiology of the host(s) and vector(s), and the ability of the parasite to adjust to the various substrates. This paper is an analytical compilation of factors which play a relevant role in the complex pathway characteristic of trypanosome transmission. These are discussed under the following headings: (a) physiology of the parasite; (b) physiology of the vector; (c) ecology of the vector; (d) feeding habits of the vector; (e) physiology of the vertebrate host; and (f) behaviour of the vertebrate host.

Key Words

Glossina Trypanosoma feeding pattern vertebrate host African trypanosomiasis 

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References

  1. Allsop R., Baldry D. A. T. and Rodrigues C. (1972) The influence of game animals on the distribution and feeding habits of Glossina pallidipes in the Lambwe Valley. Bull. Wld. Hlth. Org. 47, 795–809.Google Scholar
  2. Amreim Y. U., Geighy R and Kaufmann M. (1965) On the reacquisition of virulence in trypanosomes of the brucei group. Acta trop. 22, 193–203.Google Scholar
  3. Ashcroft M. T. (1959) The importance of African wild animals as reservoirs of trypanosomiasis. E. Afri. Med. J. 36, 247–161.Google Scholar
  4. Ashcroft M. T., Burt E. and Fairbairn H. (1959) The experimental infection of some African wild animals with T. rhodesiense, T. brucei and T. congolense. Ann. trop. Med. Parasit. 53, 137–146.PubMedCrossRefGoogle Scholar
  5. Baker J. R. (1968) Trypanosomes of wild animals in the neighbourhood of the Serengeti National Park. Symp. Zool. Soc. Lond. 24, 147–158.Google Scholar
  6. Baker J. R., Sachs R. and Laufer I. (1967) Trypanosomes of wild animals in an area northwest of the Serengeti National Park. Z. Tropenmed. Parasit. 18, 280–284.Google Scholar
  7. Burtt E. (1946) Incubation of tsetse pupae: increased transmission rate of Trypanosoma rhodesiense in Glossina morsitans. Ann. trop. Med. Parasit. 40, 18–28.PubMedCrossRefGoogle Scholar
  8. Buxton P. A. (1955) The Natural History of Tsetse Flies. Mem. London Sch. Hyg. & Trop. Med., No. 10.Google Scholar
  9. Challier A., Eyraud M., Lafaye A. and Laveissiere (1977) Amélioration du rendement de piège bicon-ique pour Glossines par l’emploi d’un cône inférieur bleu. Cah. O.R.S.T.O.M., sér. ent. med. parasit. XV, 282–286.Google Scholar
  10. Clarke J. E. (1965) Trypanosomes infections in the mouth-parts of Glossina morsitans: a correlation between the extent of labral infection and invasion of the hypopharynx. Ann. trop. Med. Parasit. 59, 235–239.PubMedCrossRefGoogle Scholar
  11. Clarke J. E. (1966) Trypanosome infections in the mouth-part of Glossina morsitans: variation in frequency and extent of labral infections with age. Ann. trop. Med. Parasit. 60, 223–229.PubMedCrossRefGoogle Scholar
  12. Clarke J. E. (1970) Trypanosome infection rates in the mouthparts of Zambian tsetse flies. Ann. trop. Med. Parasit. 64, 164–165.Google Scholar
  13. Cunningham M. P. and Vickerman K. (1962) Antigenic analyses of the Trypanosome brucei group, using the agglutination reaction. Trans. R. Soc. trop. Med. Hyg. 56, 48–59.PubMedCrossRefGoogle Scholar
  14. Damian R. T. (1964) Molecular mimicry: antigen sharing by parasite and host and its consequences. Am. Naturalist 98, 129–149.CrossRefGoogle Scholar
  15. De Andrea Silva M. A. and Marques Da Silva J. (1958) On the incidence of Trypanosomiasis in game. C.S.I.T.R., 7th Meeting, 269–272.Google Scholar
  16. Desowitz R. and Watson H. J. C. (1953) Studies on Trypanosoma vivax. Iv. The maintenance of a strain in white rats without sheepserum supplement. Ann. trop. Med. Parasit. 47, 62–67.PubMedCrossRefGoogle Scholar
  17. Dodin A. and Fromentin H. (1962) Mise en évidence d’un antigène vaccinant dans le plasme de souris expérimentalement infectées par Trypanosoma gambiense et par T. congolense. Bull. Soc. Path. exot. 55, 128–138.PubMedGoogle Scholar
  18. Erickson I. C. and Møller A. R. (1975) Tsetse fly Glossina morsitans morsitans produces ultrasound related to behaviour. Experimentia 31, 788–790.CrossRefGoogle Scholar
  19. Fairbairn H. and Burtt E. (1946) The infectivity to man of a strain of Trypanosoma rhodesience transmitted cyclically by Glossina morsitans through sheep and antelope: evidence that man requires a minimum infective dose of metacyclic trypanosomes. Ann. trop. Med. Parasit. 40, 270–313.PubMedCrossRefGoogle Scholar
  20. Fairbairn H. and Culwick A. T. (1950) The transmission of polymorphic trypanosomes. Acta trop. 7, 19–47.Google Scholar
  21. Ford J. and Leggate B. M. (1961) The geographical and climatic distribution of trypanosome infection rates in Glossina morsitans group of flies. Trans. R. Soc. trop. Med. Hyg. 55, 383–397.CrossRefGoogle Scholar
  22. Frezil J. L. (1971) Application du xénodiagnostic dans le dépistage de la trypanosomiase a T. gambiense chez des sujets immunologiquement suspect. Bull. Soc. Path. Exot. 64, 871–878.PubMedGoogle Scholar
  23. Frezil J. L. and Carnevale P. (1976) Utilisation de la carboglace pour la capture de Glossina fuscipes quan-zensis avec le piège Challier-Laveissière. Conséquences épidémiologiques. Cah. O.R.S.T.O.M., ser. Ent. méd. parasit. XIV, 225–233.Google Scholar
  24. Galun R. (1975) The role of host-blood in the feeding behaviour of ectoparasites. In Dynamic Aspects of Host-Parasite Relationship, Vol. II (Ed. by Zuckerman A.), John Wiley, New York.Google Scholar
  25. Geigy R., Kauffmann M. and Beglinger R. (1967) A survey of wild animals as potential reservoirs of trypanosomiasis in the U langa District (Tanzania). Acta trop. 24, 97–108.PubMedGoogle Scholar
  26. Geigy R. and Kauffmann M. (1973) Sleeping sickness survey in the Serengeti area (Tanzania) 1971. I. Examination of large mammals for trypanosomes. Acta. trop. 30, 12–23.PubMedPubMedCentralGoogle Scholar
  27. Geigy R. M., Kauffmann M., Mayende J. S. P., Mwambu P. M. and Onyango R. J. (1973) Isolation of Trypanosoma rhodesiense from game and domestic animals in Musoma District, Tanzania. Acta. trop. 30, 49–56.PubMedPubMedCentralGoogle Scholar
  28. Glasgow J. P. (1961) The feeding habits of Glossina swynnertoni. J. Anim. Ecol. 30, 77–85.CrossRefGoogle Scholar
  29. Glasgow J. P. and Wilson F. (1953) A census of the tsetse fly Glossina pallidipes Austen and of its host animals. J. Anim. Ecol. 22, 47–56.CrossRefGoogle Scholar
  30. Glasgow J. P., Isherwood F., Lee-Jones F. and Weitz B. (1958) Factors influencing the staple food of tsetse. J. Ann. Ecol. 27, 59–69.CrossRefGoogle Scholar
  31. Godfrey D. G. (1961) Types of Trypanosoma congolense. II. Differences in the course of infection. Ann. trop. Med. Parasit. 55, 154.PubMedCrossRefGoogle Scholar
  32. Gray A. R. (1965) Antigenic variations in a strain of Trypanosoma brucei transmitted by Glossina morsitans and G. palpalis. J. gen. Microbiol. 41, 195–214.PubMedCrossRefGoogle Scholar
  33. Gray A. R. (1975) A pattern in the development of agglutino-genic antigens of cyclically transmitted isolates of Trypanosoma gambiense. Trans. R. Soc. trop. Med. Hyg. 69, 131–138.PubMedCrossRefGoogle Scholar
  34. Harley J. M. B. (1971) Comparison of the susceptibility to infection with Trypanosoma rhodesiense of Glossina pallidipes, G. fuscipes and G. brevipalpis. Ann. trop. Med. Parasit. 65, 191–196.PubMedCrossRefGoogle Scholar
  35. Harley J. M. B., Cunningham M. P. and Van Hoeve K. (1966) The numbers of infective Trypanosoma rhodesiense extruded by Glossina morsitans during feeding. Ann. trop. Med. Parasit. 60, 455–460.CrossRefGoogle Scholar
  36. Harley J. M. B. and Wilson A. J. (1968) Comparison between Glossina morsitans, G. pallidipes and G. fuscipes as vectors of trypanosomes of the Trypanosoma congolense group; the proportions infected experimentally and the numbers of infective organisms extruded during feeding. Ann. trop. Med. Parasit. 62, 178–187.PubMedCrossRefGoogle Scholar
  37. Harmsen R. (1973) The nature of the establishment barrier for Trypanosoma brucei in the gut of Glossina pallidipes. Trans. R. Soc. trop. Med. hyg. 67, 364–373.PubMedCrossRefGoogle Scholar
  38. Isherwood F., Duffy B. J., Glasgow J. P., Lee-Jones F. and Weitz B. (1961) Further studies of the food of tsetse flies. J. Anim. Ecol. 30, 259–266.CrossRefGoogle Scholar
  39. Janssen J. A. H. A. and Wijers D. J. B. (1974) Trypanosoma simiae at the Kenya coast. A correlation between virulence and the transmitting species of Glossina. Ann. trop. Med. Parasit. 68, 5–19.PubMedCrossRefGoogle Scholar
  40. Jordan A. M. (1964) Trypanosome infection rate in Glossina morsitans submorsitans in northern Nigeria. Bull. ent. Res. 55, 219–231.CrossRefGoogle Scholar
  41. Jordan A. M. (1965) The host of Glossina as the main factor affecting trypanosome infection rates of tsetse flies in Nigeria. Tvvrans. R. Soc. trop. Med. Hyg. 59, 423–431.CrossRefGoogle Scholar
  42. Kolbe F. E. (1973) The modulated sounds made by the tsetse fly Glossina brevipalpis. Zoo. Afr. 8, 241–258.Google Scholar
  43. Lambrecht F. L. (1964) Aspects of evolution and ecology of tsetse flies and trypanosomasis in prehistoric African environment. J. Afr. Hist. 5, 1–24.CrossRefGoogle Scholar
  44. Lambrecht F. L. (1965) Biological variations in trypanosomes and their relation to the epidemiology of Chagas’ disease. Rev. Inst. Med. trop. Sao Paulo 7, 346–352.PubMedGoogle Scholar
  45. Lambrecht F. L. (1967) Trypanosomiasis in prehistoric and later human populations: a tentative reconstruction. In Diseases in Antiquity (Ed. by Brothwell and Sandson ) Ch. C. Thomas, Illinois.Google Scholar
  46. Lambrecht F. L. (1973) Colour attraction of Glossina morsitans in N’gamiland, Botswana. J. trop. med. hyg. 76, 94–96.PubMedGoogle Scholar
  47. Lamprey H. F., Glasgow J. P., Lee-Jones F. and Weitz B. (1962) A simultaneous census of the potential and actual food sources of the tsetse fly Glossina swynnertoni, Austen. J. Anim. Ecol. 31, 151–156.CrossRefGoogle Scholar
  48. Langley P. A. (1968) The effect of feeding the tsetse fly Glossina morsitans on impala blood. Bull. ent. Res. 58, 295–298.CrossRefGoogle Scholar
  49. Langley P. A. (1976) Initiation and regulation of ingestion by haematophagous arthropods. J. med. ent. 13, 121–130.CrossRefGoogle Scholar
  50. Langridge W. P. (1960) Scent attractants for tsetse flies. In Int. Sci. Comm. Tryp. Res., 8th Meeting.Google Scholar
  51. Lehman D. L. (1961) Attempts at the selective cultivation of Trypanosoma rhodesiense, T. brucei and T. congolense. Ann. Trop. Med. Parasit. 55, 440–446.CrossRefGoogle Scholar
  52. Lumsden W. H. R. (1966) Estimation of serum Igm in the diagnosis of human trypanosomiasis. Trans. R. Soc. trop. Med. Hyg. 60, 125.CrossRefGoogle Scholar
  53. Lumsden W. H. R. (1967) Trends in research on the immunology of trypanosomiasis. Bull. Wld. Hlth. Org. 37, 167–175.Google Scholar
  54. Lumsden W. H. R. and Evans D. A. (1976) Biology of the Kinetoplastida. Academic Press, London.Google Scholar
  55. Maillot L. (1961) Répartition des Glossines et maladie du sommeil suivant les races géographiques. Bull. Soc. Path. Exot. 54, 856–869.Google Scholar
  56. Marks A. D. (1966) Notes on the behaviour of tsetse flies (G. morsitans and G. pallidipes) with regard to impala. Interim report, Rhodesian Governiti., Dept. Vet. Serv., Tsetse and Trypanosomiasis Control Branch.Google Scholar
  57. Mschelbwala A. S. (1972) Trypanosoma brucei infection in the haemocele of tsetse flies. Trans. R. Soc. trop. Med. Hyg. 66, 637–643.CrossRefGoogle Scholar
  58. Nash T. A. M. (1948) A note on the effect of high temperature on the pupal stages of Glossina in relation to the transmission rate of Trypanosomes. Ann. trop. Med. Parasit. 42, 30–32.PubMedCrossRefGoogle Scholar
  59. Otieno L. H. (1973) Trypanosoma brucei in the haemo-lymph of experimentally infected young Glossina morsitans. Trans. R. Soc. trop. Med. Hyg. 67, 886–887.PubMedCrossRefGoogle Scholar
  60. Prothero R. M. (1963) Population mobility and trypanosomiasis in Africa. Bull. Wld. Hlth. Org. 28, 615–623.Google Scholar
  61. Rennisson B. D. and Robertson D. H. H. (1958) The use of carbon dioxide as an attractant for catching tsetse. E.A.T.R.O., Report 1958, p. 26.Google Scholar
  62. Rice M. J., Galun R. and Margalit J. (1973) Mouthpart sensilla of the tsetse fly and their function. III. Labrocibarial sensilla. Ann. trop. med. parasti. 67, 109–116.CrossRefGoogle Scholar
  63. Rifkin M. R. (1978) Purification and identification of the trypanocidal factor from normal human serum. 4th Int. Congr. Parasit. Warsaw, 1978, section F, p. 42.Google Scholar
  64. Rogers A. (1969) The use of dry ice in trapping tsetse. E.A.T.R.O. Report, (1969), 85–91.Google Scholar
  65. Soltys M. A. (1963) Immunity in African Trypanosomiasis. Bull. Wld. Hlth. Org. 28, 753–761.Google Scholar
  66. Soltys M. A. and Woo P. (1969) Multiplication of Trypanosoma brucei. Trans. R. Soc. trop. Med. Hyg. 63, 490–496.PubMedCrossRefGoogle Scholar
  67. Soltys M. A., Woo P. and Gillick A. C. (1969) A preliminary note on the separate and infectivity of tissue forms of Trypanosoma brucei. Trans. R. Soc. trop. Med. Hyg. 63, 495–496.PubMedCrossRefGoogle Scholar
  68. Terry R. J. (1976) Innate resistance to trypanosome infections. In Biology of the Kinetoplastida, (Ed. by Lumsden and Evans ), pp. 477–492. Academic Press, London.Google Scholar
  69. Turner D. A. (1971) Olfactory perception of live host and carbon dioxide by the tsetse fly Glossina morsitans morsitans. Bull. ent. Res. 61, 75–96.CrossRefGoogle Scholar
  70. Turner O. A. and Invest J. F. (1973) Laboratory analyses of vision in tsetse flies (Dipt.: Glossinidae,. Bull. ent. Res. 62, 342–357.CrossRefGoogle Scholar
  71. Vale G. A. (1966) Mobile attractants for tsetse flies. Arnoldia 4, No. 33.Google Scholar
  72. Vale G. A. (1974) New field methods for studying the responses of tsetse flies (Diptera: Glossinidae) to hosts. Bull. ent. Res. 64, 199–208.CrossRefGoogle Scholar
  73. Vale G. A. and Hargrove J. W. (1975) Field attraction of tsetse flies (Diptera: Glossinidae) to ox odour; the effect of dose. Trans. Rhodesian Sci. Assoc. 56, 46–50.Google Scholar
  74. Vanden Berghe L. (1956) Aspect particular de la trypanosomiasis, maladie des pêcheurs, au Lac Tumba (Congo Belge.). Ann. Soc. Bel. Med. trop. 36, 185–190.Google Scholar
  75. Vanden Berghe L. and Lambrecht F. L. (1962) Etude bioloque et écologique dans la région du Bugesera (Ruanda). Acad. R. Sci. Outre-Mer, Mem. Tome XIII.Google Scholar
  76. Vanden Berghe L. and Lambrecht F. L. (1963) The epidemiology and control of human trypanosomiasis in Glossina morsitans fly belts. Am. J. trop. Med. Hyg. 12, 129–164.CrossRefGoogle Scholar
  77. Vickerman K. (1978) Antigenic variations in trypano-somes. Nature 273, 613–617.PubMedCrossRefGoogle Scholar
  78. Weinman D. (1959) Cultivation of trypanosomes. Trans. R. Soc. trop. Med. Hyg. 51, 560–561.CrossRefGoogle Scholar
  79. Weitz B. (1960) Feeding habits of bloodsucking arthropods. Exp. Parasit. 9, 63–82.CrossRefGoogle Scholar
  80. Weitz B. (1963) The feeding habits of Glossina. Bull. Wld. Hlth. Org. 28, 711–729.Google Scholar
  81. Weitz B. (1970) Host of Glossina. In The African Trypanosomiasis (Ed. by Mulligan H. W.). Allen and Unwin, London.Google Scholar
  82. Weitz B. and Jackson C. H. N. (1955) The host-animals of Glossina morsitans at Daga-Iloi. Bull. ent. Res. 46, 531–538.CrossRefGoogle Scholar
  83. Wijers D. J. B. (1958) Factors that may influence the infection rate of Glossina palpalis with Trypanosoma gambiense. I. Age of the fly at the time of the infected feed. Ann. trop. Med. Parasit. 52, 385–389.PubMedCrossRefGoogle Scholar
  84. Wijers D. J. B. and Willet K. G. (1960) Factors that may influence the infection rate of Glossina palpalis with Trypanosoma gambiense. II. The number and the morphology of the trypanosomes present in the blood of the host at the time of the infected feed. Ann. trop. Med. Parasit. 54, 341–350.PubMedCrossRefGoogle Scholar
  85. Willett K. C. (1966) Development of the peritrophic membrane in Glossina (tsetse flies) and its relation to infection with trypanosomes. Exp. Parasit. 18, 290–295.CrossRefGoogle Scholar
  86. Williamson J. (1956) The composition of tsetse fly saliva. I. A histochemical analysis. II. Analysis of amino acids and sugars by paper partition chromatography. Ann. trop. Med. Parasit. 50, 322–333, 334–344.PubMedCrossRefGoogle Scholar

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© ICIPE 1980

Authors and Affiliations

  • F. L. Lambrecht
    • 1
  1. 1.International Centre of Insect Physiology and EcologyNairobiKenya

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