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Involvement of c-Myc-mediated transient receptor potential melastatin 8 expression in oxaliplatin-induced cold allodynia in mice

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Abstract

Background

Oxaliplatin, a platinum-based chemotherapeutic agent, induces acute cold allodynia and dysesthesia. Cold-sensitive transient receptor potential channels (TRPM8 and TRPA1) have been implicated as candidates to mediate oxaliplatin-induced cold allodynia and hyperalgesia, but precise roles of these channels remain unclear. In this study, we investigated the role of TRPM8 in oxaliplatin-induced cold allodynia.

Methods

Oxaliplatin was injected intraperitoneally in mice. Cold allodynia was evaluated by the acetone test. Expression levels of TRPM8 mRNA and protein were measured using reverse transcription-polymerase chain reaction and Western blotting, respectively.

Results

Oxaliplatin-induced cold allodynia was alleviated by the TRPM8 blockers N-(2-aminoethyl)-N-[4-(benzyloxy)-3-methoxybenzyl]-N′-(1S)-1-(phenyl) ethyl] urea and TC-I 2014. Oxaliplatin increased the expression levels of TRPM8 mRNA and protein in the dorsal root ganglia and plantar skin, respectively. Prophylactic administration of the c-Myc inhibitor 10058-F4 prevented cold allodynia and the increase of TRPM8 mRNA after oxaliplatin injection.

Conclusion

These results suggest that oxaliplatin induces cold allodynia through the increase of c-Myc-mediated TRPM8 expression in primary sensory neurons.

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References

  1. Park SB, Goldstein D, Krishnan AV, Lin CS, Friedlander ML, Cassidy J, et al. Chemotherapy-induced peripheral neurotoxicity: a critical analysis. CA Cancer J Clin 2013;63:419–37.

    Article  Google Scholar 

  2. Quasthoff S, Hartung HP. Chemotherapy-induced peripheral neuropathy. J Neurol 2002;249:9–17.

    Article  CAS  Google Scholar 

  3. Pachman DR, Qin R, Seisler DK, Smith EM, Beutler AS, Ta LE, et al. Clinical course of oxaliplatin-induced neuropathy: results from the randomized phase III trial N08CB (Alliance). J Clin Oncol 2015;33:3416–22.

    Article  CAS  Google Scholar 

  4. Binder A, Stengel M, Maag R, Wasner G, Schoch R, Moosig F, et al. Pain in oxaliplatin-induced neuropathy—sensitisation in the peripheral and central nociceptive system. Eur J Cancer 2007;43:2658–63.

    Article  CAS  Google Scholar 

  5. Zhao M, Isami K, Nakamura S, Shirakawa H, Nakagawa T, Kaneko S. Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice. Mol Pain 2012;8:55.

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Gauchan P, Andoh T, Kato A, Kuraishi Y. Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice. Neurosci Lett 2009;458:93–5.

    Article  CAS  Google Scholar 

  7. Nassini R, Gees M, Harrison S, De SG, Materazzi S, Moretto N, et al. Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation. Pain 2011;152:1621–31.

    Article  CAS  Google Scholar 

  8. Stucky CL, Dubin AE, Jeske NA, Malin SA, McKemy DD, Story GM. Roles of transient receptor potential channels in pain. Brain Res Rev 2009;60:2–23.

    Article  CAS  Google Scholar 

  9. Tominaga M, Caterina MJ. Thermosensation and pain. J Neurobiol 2004;61:3–12.

    Article  Google Scholar 

  10. Chen J, Kang D, Xu J, Lake M, Hogan JO, Sun C, et al. Species differences and molecular determinant of TRPA1 cold sensitivity. Nat Commun 2013;4:2501.

    Article  Google Scholar 

  11. Kono T, Satomi M, Suno M, Kimura N, Yamazaki H, Furukawa H, et al. Oxaliplatin-induced neurotoxicity involves TRPM8 in the mechanism of acute hypersensitivity to cold sensation. Brain Behav 2012;2:68–73.

    Article  Google Scholar 

  12. Zhang L, Barritt GJ. TRPM8 in prostate cancer cells: a potential diagnostic and prognostic marker with a secretory function? Endocr Relat Cancer 2006;13: 27–38.

    Article  Google Scholar 

  13. Gauchan P, Andoh T, Kato A, Sasaki A, Kuraishi Y. Effects of the prostaglandin E1 analog limaprost on mechanical allodynia caused by chemotherapeutic agents in mice. J Pharmacol Sci 2009;109:469–72.

    Article  CAS  Google Scholar 

  14. Parks DJ, Parsons WH, Colburn RW, Meegalla SK, Ballentine SK, Illig CR, et al. Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. J Med Chem 2011;54:233–47.

    Article  CAS  Google Scholar 

  15. Sasaki A, Mizoguchi S, Kagaya K, Shiro M, Sakai A, Andoh T, et al. A mouse model of peripheral postischemic dysesthesia: involvement of reperfusion-induced oxidative stress and TRPA1 channel. J Pharmacol Exp Ther 2014;351: 568–75.

    Article  Google Scholar 

  16. Guo J, Parise RA, Joseph E, Egorin MJ, Lazo JS, Prochownik EV, et al. Efficacy, pharmacokinetics, tissue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice. Cancer Chemother Pharmacol 2009;63:615–25.

    Article  CAS  Google Scholar 

  17. Cole MD. Myc meets its Max. Cell 1991;65:715–6.

    Article  CAS  Google Scholar 

  18. Yin X, Giap C, Lazo JS, Prochownik EV. Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene 2003;22:6151–9.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan

    Shizuka Mizoguchi & Tsugunobu Andoh

  2. Department of Organomolecular Chemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan

    Takayuki Yakura

  3. Tokyo Medical and Dental University, Tokyo, Japan

    Yasushi Kuraishi

Authors
  1. Shizuka Mizoguchi
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  2. Tsugunobu Andoh
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  3. Takayuki Yakura
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  4. Yasushi Kuraishi
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Corresponding author

Correspondence to Tsugunobu Andoh.

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Mizoguchi, S., Andoh, T., Yakura, T. et al. Involvement of c-Myc-mediated transient receptor potential melastatin 8 expression in oxaliplatin-induced cold allodynia in mice. Pharmacol. Rep 68, 645–648 (2016). https://doi.org/10.1016/j.pharep.2016.03.001

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  • DOI: https://doi.org/10.1016/j.pharep.2016.03.001

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