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Multifunctional drugs for head injury
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  • Review Article
  • Published: January 2009

Multifunctional drugs for head injury

  • Robert Vink1 &
  • Alan J. Nimmo1 

Neurotherapeutics volume 6, pages 28–42 (2009)Cite this article

  • 1185 Accesses

  • 117 Citations

  • 13 Altmetric

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Summary

Traumatic brain injury (TBI) remains one of the leading causes of mortality and morbidity worldwide in individuals under the age of 45 years, and, despite extensive efforts to develop neuroprotective therapies, there has been no successful outcome in any trial of neuroprotection to date. In addition to recognizing that many TBI clinical trials have not been optimally designed to detect potential efficacy, the failures can be attributed largely to the fact that most of the therapies investigated have been targeted toward an individual injury factor. The contemporary view of TBI is that of a very heterogenous type of injury, one that varies widely in etiology, clinical presentation, severity, and pathophysiology. The mechanisms involved in neuronal cell death after TBI involve an interaction of acute and delayed anatomic, molecular, biochemical, and physiological events that are both complex and multifaceted. Accordingly, neuropharmacotherapies need to be targeted at the multiple injury factors that contribute to the secondary injury cascade, and, in so doing, maximize the likelihood of a successful outcome. This review focuses on a number of such multifunctional compounds that have shown considerable success in experimental studies and that show maximum promise for success in clinical trials.

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    Robert Vink & Alan J. Nimmo

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Vink, R., Nimmo, A.J. Multifunctional drugs for head injury. Neurotherapeutics 6, 28–42 (2009). https://doi.org/10.1016/j.nurt.2008.10.036

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Key Words

  • Neurotrauma
  • statins
  • progesterone
  • erythropoietin
  • cyclosporin
  • toll-like receptors
  • magnesium
  • dexanabinol
  • bradykinin
  • substance P
  • minocycline
  • thyrotropin releasing hormone
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