Skip to main content
Log in

Future directions of myocardial fatty acid imaging

  • Original Articles
  • Published:
Journal of Nuclear Cardiology Aims and scope

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Taegtmeyer H, King LM, Jones BE. Energy substrate metabolism, myocardial ischemia, and targets for pharmacotherapy. Am J Cardiol 1998;82:54K-60K.

    Article  PubMed  CAS  Google Scholar 

  2. Lopaschuk G. Regulation of carbohydrate metabolism in ischemia and reperfusion. Am Heart J 2000;139:S115–9.

    Article  Google Scholar 

  3. McVeigh JJ, Lopaschuk GD. Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic rat hearts. Am J Physiol 1990;259:H1079–85.

    PubMed  CAS  Google Scholar 

  4. Broderick TL, Quinney HA, Lopaschuk GD. Carnitine stimulation of glucose oxidation in the fatty acid perfused isolated working rat heart. J Biol Chem 1992;267:3758–63.

    PubMed  CAS  Google Scholar 

  5. McCormack JG, Barr RL, Wolff AA, Lopaschuk GD. Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts. Circulation 1996;93:135–42.

    PubMed  CAS  Google Scholar 

  6. Dilsizian V, Bateman TM, Bergmann SR, et al. Metabolic imaging with β-methyl-p-[123I]-iodophenyl-pentadecanoic acid identifies ischemic memory after demand ischemia. Circulation 2005;112: 2169–74.

    Article  PubMed  Google Scholar 

  7. Goldstein RA, Klein MS, Welch MJ, Sobel BE. External assessment of myocardial metabolism with C-11 palmitate in vivo. J Nucl Med 1980;21:342–8.

    PubMed  CAS  Google Scholar 

  8. Schon HR, Schelbert HR, Robinson G, et al. C-11 labeled palmitic acid for the noninvasive evaluation of regional myocardial fatty acid metabolism with positron-computed tomography. I. Kinetics of C-11 palmitic acid in normal myocardium. Am Heart J 1982; 103:532–47.

    Article  PubMed  CAS  Google Scholar 

  9. Reske SN, Biersack HJ, Lackner K, et al. Assessment of regional myocardial uptake and metabolism of omega-(p-123I-phenyl) pentadecanoic acid with serial single-photon emission tomography. Nuklearmedizin 1982;21:249–53.

    PubMed  CAS  Google Scholar 

  10. Yang JY, Ruiz M, Calnon DA, et al. Assessment of myocardial viability using 123I-labeled iodophenylpentadecanoic acid at sustained low flow or after acute infarction and reperfusion. J Nucl Med 1999;40:821–8.

    PubMed  CAS  Google Scholar 

  11. Caldwell JH, Martin GV, Link JM, et al. Iodophenylpentadecanoic acid-myocardial blood flow relationship during maximal exercise with coronary occlusion. J Nucl Med 1990;31:99–105.

    PubMed  CAS  Google Scholar 

  12. Murray G, Schad N, Ladd W, et al. Metabolic cardiac imaging in severe coronary disease: assessment of viability with iodine-123-iodophenylpentadecanoic acid and multicrystal gamma camera, and correlation with biopsy. J Nucl Med 1992;33: 1269–77.

    PubMed  CAS  Google Scholar 

  13. Verani MS, Taillefer R, Iskandrian AE, et al. 123I-IPPA SPECT for the prediction of enhanced left ventricular function after coronary bypass graft surgery. Multicenter IPPA Viability Trial Investigators. 123I-iodophenylpentadecanoic acid. J Nucl Med 2000;41: 1299–307.

    PubMed  CAS  Google Scholar 

  14. Goodman MM, Kirsch G, Knapp FF. Synthesis and evaluation of radioiodinated terminal p-iodophenyl-substituted α- and β-methyl branched fatty acids. J Med Chem 1984;27:390–7.

    Article  PubMed  CAS  Google Scholar 

  15. Knapp FF, Kropp J. Iodine 123-labelled fatty acids for myocardial single-photon tomography: current status and future perspectives. Eur J Nucl Med 1995;22:361–81.

    Article  PubMed  CAS  Google Scholar 

  16. Tamaki N, Kawamoto M, Yonekura Y, et al. Regional metabolic abnormality in relation to perfusion and wall motion in patients with myocardial infarction: assessment with emission tomography using an iodinated branched fatty acid analog. J Nucl Med 1992;33:659–67.

    PubMed  CAS  Google Scholar 

  17. Hambye AS, Vaerenberg MM, Dobbeleir AA, et al. Abnormal BMIPP uptake in chronically dysfunctional myocardial segments: correlation with contractile response to low-dose dobutamine. J Nucl Med 1998;39:1845–50.

    PubMed  CAS  Google Scholar 

  18. Kudoh T, Tadamura E, Tamaki N, et al. Iodinated free fatty acid and 201T1 uptake in chronically hypoperfused myocardium: histologic correlation study. J Nucl Med 2000;41:293–6.

    PubMed  CAS  Google Scholar 

  19. Franken PR, Dendale P, De Geeter F, et al. Prediction of functional outcome after myocardial infarction using BMIPP and sestamibi scintigraphy. J Nucl Med 1996;37:718–22.

    PubMed  CAS  Google Scholar 

  20. Ito T, Tanouchi J, Kato J, et al. Recovery of impaired left ventricular function in patients with acute myocardial infarction is predicted by the discordance in defect size on 123I-BMIPP and 201Tl SPECT images. Eur J Nucl Med 1996;23:917–23.

    Article  PubMed  CAS  Google Scholar 

  21. Hashimoto A, Nakata T, Tsuchihashi K, et al. Postischemic functional recovery and BMIPP uptake after primary percutaneous transluminal coronary angioplasty in acute myocardial infarction. Am J Cardiol 1996;77:25–30.

    Article  PubMed  CAS  Google Scholar 

  22. Ryan TJ, Anderson JL, Antman EM, et al. ACC/AHA guidelines for the management of patients with acute myocardial infarction. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial Infarction). J Am Coll Cardiol 1996;28:1328–428.

    Article  PubMed  CAS  Google Scholar 

  23. Burt CW. Summary statistics for acute cardiac ischemia and chest pain visits to United States EDs, 1995–1996. Am J Emerg Med 1999;17:552–9.

    Article  PubMed  CAS  Google Scholar 

  24. Brodie BR, Hansen C, Stuckey TD, et al. Door-to-balloon time with primary percutaneous coronary intervention for acute myocardial infarction impacts late cardiac mortality in high-risk patients and patients presenting early after the onset of symptoms. J Am Coll Cardiol 2006;47:289–95.

    Article  PubMed  Google Scholar 

  25. Udelson JE, Beshansky JR, Ballin DS, et al. Myocardial perfusion imaging for evaluation and triage of patients with suspected acute cardiac ischemia; a randomized controlled trial. JAMA 2002;288: 2693–700.

    Article  PubMed  Google Scholar 

  26. Klocke FJ, Baird MG, Lorell BH, et al. ACC/AHA/ASNC guide-lines for the clinical use of cardiac radionuclide imaging— executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASNC Committee to Revise the 1995 Guidelines for the Clinical Use of Cardiac Radionuclide Imaging). Circulation 2003;108:1404–18.

    Article  PubMed  Google Scholar 

  27. Tatum JL, Jesse RL, Kontos MC, et al. Comprehensive strategy for the evaluation and triage of the chest pain patient. Ann Emerg Med 1997;29:116–25.

    Article  PubMed  CAS  Google Scholar 

  28. Kawai Y, Tsukamoto E, Nozaki Y, et al. Significance of reduced uptake of iodinated fatty acid analogue for the evaluation of patients with acute chest pain. J Am Coll Cardiol 2001;38: 1888–94.

    Article  PubMed  CAS  Google Scholar 

  29. Taegtmeyer H, Goodwin GW, Doenst T, Frazier OH. Substrate metabolism as a determinant for postischemic functional recovery of the heart. Am J Cardiol 1997;80:3A-10A.

    Article  PubMed  CAS  Google Scholar 

  30. Sato H, Iwasaki T, Toyama T, et al. Prediction of functional recovery after revascularization in coronary artery disease using 18F-FDG and 123I-BMIPP SPECT. Chest 2000;117:65–72.

    Article  PubMed  CAS  Google Scholar 

  31. Seki H, Toyama T, Higuchi K, et al. Prediction of functional improvement of ischemic myocardium with 123I-BMIPP SPECT and 99mTc-tetrofosmin SPECT imaging: a study of patients with large acute myocardial infarction and receiving revascularization therapy. Circ J 2005;69:311–9.

    Article  PubMed  Google Scholar 

  32. Antman EM, Anbe DT, Armstrong PW, et al. ACC/AHA guide-lines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Management of Patients with Acute Myocardial Infarction). Circulation 2004;110: e82–292.

    Article  PubMed  Google Scholar 

  33. Al-Khatib SM, Sanders GD, Mark DB, et al. Implantable cardioverter-defibrillators and cardiac resynchronization therapy in patients with left ventricular dysfunction: randomized trial evidence through 2004. Am Heart J 2005;149:1020–34.

    Article  PubMed  Google Scholar 

  34. Solomon SD, Zelenkofske S, McMurray JJV, et al., for the Valsartan in Acute Myocardial Infarction Trial (VALIANT) Investigators. Sudden death in patients with myocardial infarction and left ventricular dysfunction, heart failure, or both. N Engl J Med 2004;325:2581–8.

    Google Scholar 

  35. Hohnloser SH, Kuck KH, Dorian P, et al. Prophylactic use of an implantable cardioverter-defibrillator after acute myocardial infarction. N Engl J Med 2004;351:2481–8.

    Article  PubMed  CAS  Google Scholar 

  36. Buxton AE. Sudden death after myocardial infarction—who needs prophylaxis, and when? N Engl J Med 2004;325:2638–40.

    Google Scholar 

  37. Stecker EC, Vickers C, Waltz J, et al. Population-based analysis of sudden cardiac death with and without left ventricular systolic dysfunction: two-year findings from the Oregon sudden unexpected death study. J Am Coll Cardiol 2006;47:1161–6.

    Article  PubMed  Google Scholar 

  38. Bolognese L, Carrabba N, Parodi G, et al. Impact of microvascular dysfunction on left ventricular remodeling and long-term clinical outcome after primary coronary angioplasty for acute myocardial infarction. Circulation 2004;109:1121–6.

    Article  PubMed  Google Scholar 

  39. Gibson CM. Has my patient achieved adequate myocardial reperfusion? Circulation 2003;108:504–7.

    Article  PubMed  Google Scholar 

  40. Jeremias A, Gibson CM. Narrative review: alternative causes for elevated cardiac troponin levels when acute coronary syndromes are excluded. Ann Intern Med 2005;142:786–91.

    PubMed  Google Scholar 

  41. El Fakhri G, Sitek A, Zimmerman RE, Ouyang J. Generalized five-dimensional dynamic and spectral factor analysis. Med Phys 2006;33:1016–24.

    Article  PubMed  Google Scholar 

  42. El Fakhri G, Habert MO, Maksud P, et al. Quantitative simultaneous 99mTc-ECD/123I-FP-CIT SPECT in Parkinson’s disease and multiple system atrophy. Eur J Nucl Med Mol Imaging 2006;33:87–92.

    Article  PubMed  Google Scholar 

  43. Gibbons RJ, Eckel RH, Jacobs AK, et al, for the American Heart Association Science Advisory and Coordinating Committee. The utilization of cardiac imaging. Circulation 2006;113:1715–6.

    Article  PubMed  Google Scholar 

  44. Taegtmeyer H. Metabolism—the lost child of cardiology. J Am Coll Cardiol 2000;36:1386–8.

    Article  PubMed  CAS  Google Scholar 

  45. Hashimoto A, Nakata T, Nagao K, et al. Prediction of left ventricular functional recovery in patients with acute myocardial infarction using single photon emission computed tomography with thallium-201 and iodine-123-beta-methyl-p-iodophenyl-pentadecanoic acid. J Cardiol 1995;26:59–68. Japanese.

    PubMed  CAS  Google Scholar 

  46. Nishimura T, Nishimura S, Kajiya T, et al. Prediction of functional recovery and prognosis in patients with acute myocardial infarction by 123I-BMIPP and 201Tl myocardial single photon emission computed tomography: a multicenter trial. Ann Nucl Med 1998;12:237–48.

    Article  PubMed  CAS  Google Scholar 

  47. Fujiwara S, Takeishi Y, Atsumi H, et al. Prediction of functional recovery in acute myocardial infarction: comparison between sestamibi reverse redistribution and sestamibi/BMIPP mismatch. J Nucl Cardiol 1998;5:119–27.

    Article  PubMed  CAS  Google Scholar 

  48. Hambye AS, Vervaet A, Dobbeleir A, Dendale P, Franken P. Prediction of functional outcome by quantification of sestamibi and BMIPP after acute myocardial infarction. Eur J Nucl Med 2000;27:1494–500.

    Article  PubMed  CAS  Google Scholar 

  49. Akimoto N. Prediction of improvement of left ventricular wall motion in patients with myocardial infarction—by using 99mTc-tetrofosmin and 123I-BMIPP myocardial SPECT at subacute phase. Kaku Igaku 2000;37:291–301. Japanese.

    PubMed  CAS  Google Scholar 

  50. Yasugi N, Koyanagi S, Ohzono K, et al. Comparative study of dobutamine stress echocardiography and dual single-photon emission computed tomography (thallium-201 and I-123 BMIPP) for assessing myocardial viability after acute myocardial infarction. Circ J 2002;66:1132–8.

    Article  PubMed  Google Scholar 

  51. Akutsu Y, Kodama Y, Nishimura H, et al. Contractile reserve, thallium-201 reverse redistribution and mismatch between perfusion and metabolism in reperfused infarct-related myocardium with delayed and incomplete functional recovery. Jpn Heart J 2004;45:739–48.

    Article  PubMed  Google Scholar 

  52. Tani T, Teragaki M, Watanabe H, et al. Detecting viable myocardium and predicting functional improvement: comparisons of positron emission tomography, rest-redistribution thallium-201 single-photon emission computed tomography (SPECT), exercise thallium-201 reinjection SPECT, I-123 BMIPP SPECT and dobutamine stress echocardiography. Circ J 2004;68:950–7.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to James E. Udelson.

Additional information

Dr Pastore is supported by a Herbert J. Levine Foundation grant and by an American Society of Nuclear Cardiology-Astellas Research Grant award.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pastore, C.J., Babich, J.W. & Udelson, J.E. Future directions of myocardial fatty acid imaging. J Nucl Cardiol 14, S153–S163 (2007). https://doi.org/10.1016/j.nuclcard.2007.02.013

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1016/j.nuclcard.2007.02.013

Keywords

Navigation