Conclusion
Metabolic adaptation may represent one of the earliest responses to myocardial ischemia, left ventricular remodeling, diabetes, and uremic heart disease. Thus targeting alterations in myocellular metabolism may foster novel and effective therapeutic interventions. In the future, recognizing key intracellular signals that link energy substrate metabolism with gene expression will allow the discovery of more specific molecular targets for the diagnosis and treatment of cardiovascular disease.
References
Evans CL, Grande F, Hsu FY. The glucose and lactate consumption of the dog’s heart. Q J Exp Physiol 1935;24:347–64.
Bing RJ. The metabolism of the heart. In: Harvey Lecture Series. Series 50. New York: Academic Press; 1954. p. 27–70.
Taegtmeyer H, Woods A. Clinical trials report. Metabolic modulation as a principle for myocardial protection. Curr Hypertens Rep 2003;5:443–4.
Depre C, Taegtmeyer H. Metabolic aspects of programmed cell survival and cell death in the heart. Cardiovasc Res 2000;45: 538–48.
Dilsizian V, Bonow RO. Current diagnostic techniques of assessing myocardial viability in hibernating and stunned myocardium. Circulation 1993;87:1–20.
Dilsizian V, Bateman TM, Bergmann SR, et al. Metabolic imaging with β-methyl-p-[123I]-iodophenyl-pentadecanoic acid (BMIPP) identifies ischemic memory following demand ischemia. Circulation 2005;112:2169–74.
Dilsizian V, Rocco TP, Freedman NM, Leon MB, Bonow RO. Enhanced detection of ischemic but viable myocardium by the reinjection of thallium after stress-redistribution imaging. N Engl J Med 1990;323:141–6.
Evans JR, Gunton RW, Baker RG, et al. Use of radioiodinated fatty acids for photoscans of the heart. Circ Res 1965;16:1–10.
Ter-Pogossian MM, Klein MS, Markham J, Roberts R, Sobel BE. Regional assessment of myocardial metabolic integrity in vivo by positron emission tomography with 11C-labelled palmitate. Circulation 1980;61:242–55.
Goodman MM, Kirsch G, Knapp FF Jr. Synthesis and evaluation of radioiodinated terminal p-iodophenyl substituted alpha- and beta-methyl-branched fatty acids. J Med Chem 1984;27:390–7.
Knapp FF Jr, Ambrose KR, Goodman MM. New radioiodinated methyl branched fatty acids for cardiac studies. Eur J Nucl Med 1986;12:S39–44.
Hosokawa R, Nohara R, Fujibayashi Y, et al. Myocardial kinetics of iodine-123-BMIPP in canine myocardium after regional ischemia and reperfusion: implications for clinical SPECT. J Nucl Med 1997;38:1857–63.
Borgers M, Ausma J. Structural aspects of the chronic hibernating myocardium in man. Basic Res Cardiol 1995;90:44–6.
Tillisch JH, Brunken R, Marshall R, et al. Reversibility of cardiac wall-motion abnormalities predicted by positron tomography. N Engl J Med 1986;314:884–8.
Kawai Y, Tsukamoto E, Nozaki Y, Morita K, Sakurai M, Tamaki N. Significance of reduced uptake of iodinated fatty acid analogue for the evaluation of patients with acute chest pain. J Am Coll Cardiol 2001;38:1888–94.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Dilsizian, V. Metabolic adaptation to myocardial ischemia: The role of fatty acid imaging. J Nucl Cardiol 14, S97–S99 (2007). https://doi.org/10.1016/j.nuclcard.2007.02.008
Issue Date:
DOI: https://doi.org/10.1016/j.nuclcard.2007.02.008