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Regional heterogeneity of resting perfusion in hypertrophic cardiomyopathy is related to delayed contrast enhancement but not to systolic function: A PET and MRI study

  • Original Article
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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

Regional differences in resting myocardial blood flow (MBF) have been observed in patients with hypertrophic cardiomyopathy (HCM), but their determinants are currently unknown. This study verifies whether MBF at rest in HCM is related to delayed contrast enhancement (DCE) or regional systolic function (or both) as determined by magnetic resonance imaging.

Methods and Results

Fourteen patients with HCM were studied. MBF was measured with positron emission tomography by use of oxygen 15-labeled water. DCE and tissue tagging, to calculate end-systolic circumferential shortening (Ecc), were obtained with magnetic resonance imaging. The mean resting MBF was 0.78 ± 0.19 mL . min-1 . mL-1, and there was a trend toward reduced MBF in the septum (0.72 ± 0.11 mL . min-1 . mL-1) compared with that in the lateral wall (0.84 ± 0.29 mL . min-1 . mL-1) (P -.092). The distribution patterns of DCE and Ecc were both heterogeneous, displaying significantly increased enhancement and impaired regional systolic function in the hypertrophic septum compared with the lateral wall (both P < .001). Resting MBF was inversely related to the extent of DCE (r - 0.30, P < .001), whereas MBF was not significantly related to Ecc (r -0.15, P - .072).

Conclusions

Regional heterogeneity of resting perfusion in HCM is related to the extent of DCE but not to regional systolic function.

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Authors and Affiliations

  1. Department of Cardiology, VU University Medical Center, De Boelelaan 1117, 6D 120, 1081 HV, Amsterdam, The Netherlands

    Paul Knaapen, Willem G. van Dockum, Marco J. W. Götte, Kimiko A. Broeze, Albert C. van Rossum & Frans C. Visser

  2. Physics and Medical Technology, The Netherlands

    Joost P. A. Kuijer, Jaco J. M. Zwanenburg & J. Tim Marcus

  3. VU University Medical Center, Institute for Cardiovascular Research, and Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Wouter E. M. Kok

  4. Nuclear Medicine and PET Research, The Netherlands

    Adriaan A. Lammertsma

Authors
  1. Paul Knaapen
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  2. Willem G. van Dockum
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  3. Marco J. W. Götte
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  4. Kimiko A. Broeze
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  7. Joost P. A. Kuijer
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  10. Wouter E. M. Kok
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Corresponding author

Correspondence to Paul Knaapen.

Additional information

Willem G. van Dockum is supported by the Netherlands Heart Foundation (grant 1999B203).

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Knaapen, P., van Dockum, W.G., Götte, M.J.W. et al. Regional heterogeneity of resting perfusion in hypertrophic cardiomyopathy is related to delayed contrast enhancement but not to systolic function: A PET and MRI study. J Nucl Cardiol 13, 660–667 (2006). https://doi.org/10.1016/j.nuclcard.2006.05.018

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  • DOI: https://doi.org/10.1016/j.nuclcard.2006.05.018

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