Summary
HIF-1α is critical to somitogenesis. Lack of HIF-1α disrupts the Notch signaling pathway which leads to vertebral malformations seen in congenital scoliosis
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Author disclosures: Angela Yao: none. Frances Farley: none. Ernestina Schipani: none.
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Yao, A., Farley, F. & Schipani, E. Paper #16: HIF-1α critical to Somitogenesis and interacts with the Notch pathway leading to vertebral malformations. Spine Deform 5, 447 (2017). https://doi.org/10.1016/j.jspd.2017.09.019
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DOI: https://doi.org/10.1016/j.jspd.2017.09.019