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A Case-Control Study of Body Composition, Prevalence, and Curve Severity of the Patients With Adolescent Idiopathic Scoliosis in the East Part of China

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Abstract

Objective

The purpose of the study is to investigate the characteristics of prevalence and curve severity in patients with adolescent idiopathic scoliosis (AIS) and the body composition alterations between the patients with AIS and healthy controls.

Methods

Information on the study sample was obtained from a screening database. The AIS cohort was paired with an age- and gender-matched healthy cohort. The stratification of BMI and curve severity was conducted according to the criteria developed by the US Centers for Disease Control and Prevention and the Scoliosis Research Society. The prevalence and curve severity of the patients with AIS were investigated. Multigroup comparison of body composition parameters was conducted according to BMI between the patients with AIS and healthy controls.

Results

A total of 1,202 patients with AIS and an age- and gender-matched cohort were recruited from local schools. The underweight cases had the highest prevalence of AIS and significantly higher Cobb angle compared with the other three BMI subgroups. Although the patients with AIS had lower body weight, body fat mass, percentage of body fat, and fat-free mass compared with healthy controls, converse results were observed in the underweight cases after stratification according to BMI.

Conclusion

Based on the sporadic body composition of the patients with AIS observed in the current study, it is predictable that the pathophysiological alterations may be different before and after the onset of scoliosis. Well-designed human or animal studies for underweight patients would be helpful to reveal the mechanisms of pathophysiological alterations and better predict the development of AIS.

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References

  1. Ogilvie JW, Braun J, Argyle V, et al. The search for idiopathic scoliosis genes. Spine (Phila Pa 1976) 2006;31:679–81.

    Article  Google Scholar 

  2. Zhang H, Guo C, Tang M, et al. Prevalence of scoliosis among primary and middle school students in Mainland China: a systematic review and meta-analysis. Spine 2015;40:41–9.

    Article  Google Scholar 

  3. Archer IA, Dickson RA. Stature and idiopathic scoliosis. A prospective study. J Bone Joint Surg Br 1985;67:185–8.

    Article  CAS  Google Scholar 

  4. Buric M, Momcilovic B. Growth pattern and skeletal age in school girls with idiopathic scoliosis. Clin Orthop Relat Res 1982;170:238–42.

    Google Scholar 

  5. Cheng JC, Guo X. Osteopenia in adolescent idiopathic scoliosis. A primary problem or secondary to the spinal deformity? Spine (Phila Pa 1976) 1997;22:1716–21.

    Article  CAS  Google Scholar 

  6. Cheng JC, Guo X, Sher AH. Persistent osteopenia in adolescent idiopathic scoliosis. A longitudinal follow up study. Spine (Phila Pa 1976) 1999;24:1218–22.

    Article  CAS  Google Scholar 

  7. Cheng JC, Qin L, Cheung CS, et al. Generalized low areal and volumetric bone mineral density in adolescent idiopathic scoliosis. J Bone Miner Res 2000;15:1587–95.

    Article  CAS  Google Scholar 

  8. Cheung CS, Lee WT, Tse YK, et al. Generalized osteopenia in adolescent idiopathic scoliosis—association with abnormal pubertal growth, bone turnover, and calcium intake? Spine (Phila Pa 1976) 2006;31:330–8.

    Article  Google Scholar 

  9. Cook SD, Harding AF, Morgan EL, et al. Trabecular bone mineral density in idiopathic scoliosis. J Pediatr Orthop 1987;7:168–74.

    Article  CAS  Google Scholar 

  10. Liu Z, Tam EM, Sun GQ, et al. Abnormal leptin bioavailability in adolescent idiopathic scoliosis: an important new finding. Spine (Phila Pa 1976) 2012;37:599–604.

    Article  Google Scholar 

  11. Nordwall A, Willner S. A study of skeletal age and height in girls with idiopathic scoliosis. Clin Orthop Relat Res 1975;110:6–10.

    Article  Google Scholar 

  12. Siu King Cheung C, Tak Keung Lee W, Kit Tse Y, et al. Abnormal peri-pubertal anthropometric measurements and growth pattern in adolescent idiopathic scoliosis: a study of 598 patients. Spine (Phila Pa 1976) 2003;28:2152–7.

    Article  Google Scholar 

  13. Wang WJ, Hung VW, Lam TP, et al. The association of disproportionate skeletal growth and abnormal radius dimension ratio with curve severity in adolescent idiopathic scoliosis. Eur Spine J 2010;19:726–31.

    Article  Google Scholar 

  14. Willner S. A study of growth in girls with adolescent idiopathic structural scoliosis. Clin Orthop Relat Res 1974;101:129–35.

    Google Scholar 

  15. Willner S. Growth in height of children with scoliosis. Acta Orthop Scand 1974;45:854–66.

    Article  CAS  Google Scholar 

  16. Grivas TB, Arvaniti A, Maziotou C, et al. Comparison of body weight and height between normal and scoliotic children. Stud Health Technol Inform 2002;91:47–53.

    Google Scholar 

  17. Sadat-Ali M, Al-Othman A, Bubshait D, Al-Dakheel D. Does scoliosis cause low bone mass? A comparative study between siblings. Eur Spine J 2008;17:944–7.

    Article  Google Scholar 

  18. Dangerfield P, Davey R, Chockalingam N, et al. Body composition in females with adolescent idiopathic scoliosis (AIS). J Bone Joint Surg Br 2006;88:230–1.

    Google Scholar 

  19. Hung VW, Qin L, Cheung CS, et al. Osteopenia: a new prognostic factor of curve progression in adolescent idiopathic scoliosis. J Bone Joint Surg Am 2005;87:2709–16.

    CAS  PubMed  Google Scholar 

  20. Barrios C, Cortes S, Perez-Encinas C, et al. Anthropometry and body composition profile of girls with nonsurgically treated adolescent idiopathic scoliosis. Spine (Phila Pa 1976) 2011;36:1470–7.

    Article  Google Scholar 

  21. Ramirez M, Martinez-Llorens J, Sanchez JF, et al. Body composition in adolescent idiopathic scoliosis. Eur Spine J 2013;22:324–9.

    Article  Google Scholar 

  22. Mullie P, Vansant G, Hulens M, et al. Evaluation of body fat estimated from body mass index and impedance in Belgian male military candidates: comparing two methods for estimating body composition. Mil Med 2008;173:266–70.

    Article  Google Scholar 

  23. Negrini S, Aulisa AG, Aulisa L, et al. 2011 SOSORT guidelines: orthopaedic and rehabilitation treatment of idiopathic scoliosis during growth. Scoliosis 2012;7:3.

    Article  Google Scholar 

  24. Gandhi PK, Revicki DA, Huang IC. Adolescent body weight and health-related quality of life rated by adolescents and parents: the issue of measurement bias. BMC Public Health 2015;15:1192.

    Article  Google Scholar 

  25. Hershkovich O, Friedlander A, Gordon B, et al. Association between body mass index, body height, and the prevalence of spinal deformities. Spine J 2014;14:1581–7.

    Article  Google Scholar 

  26. Burwell R, Dangerfield P, Moulton A, Anderson S. Etiologic theories of idiopathic scoliosis: autonomic nervous system and the leptin-sympathetic nervous system concept for the pathogenesis of adolescent idiopathic scoliosis. Stud Health Technol Inform 2008;140:197.

    CAS  PubMed  Google Scholar 

  27. Tam EM, Liu Z, Lam TP, et al. Lower muscle mass and body fat in adolescent idiopathic scoliosis are associated with abnormal leptin bioavailability. Spine (Phila Pa 1976) 2016;41:940–6.

    Article  Google Scholar 

  28. Blum WF, Englaro P, Hanitsch S, et al. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. J Clin Endocrinol Metab 1997;82:2904–10.

    CAS  PubMed  Google Scholar 

  29. Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactiveleptin concentrations in normal-weight and obese humans. N Engl J Med 1996;334:292–5.

    Article  CAS  Google Scholar 

  30. Zoabli G, Mathieu PA, Aubin CE. Back muscles biometry in adolescent idiopathic scoliosis. Spine J 2007;7:338–44.

    Article  Google Scholar 

  31. Shimode M, Ryouji A, Kozo N. Asymmetry of premotor time in the back muscles of adolescent idiopathic scoliosis. Spine (Phila Pa 1976) 2003;28:2535–9.

    Article  Google Scholar 

  32. Cheon M, Park J, Lee Y, Lee J. Effect of chiropractic and lumbar exercise program on lumbar muscle strength and Cobb’s angle in patients with scoliosis for u-Healthcare. EURASIP J Wireless Commun Network 2013;2013:1–6.

    Article  Google Scholar 

  33. Otman S, Kose N, Yakut Y. The efficacy of Schroth’s 3-dimensional exercise therapy in the treatment of adolescent idiopathic scoliosis in Turkey. Saudi Med J 2005;26:1429–35.

    PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Interdisciplinary Division of Biomedical Engineering, The Hong Kong Polytechnic University, 11 Yuk Choi Road, Hung Hom, Kowloon, Hong Kong, 999077, China

    Yu Zheng MD & M. S. Wong PhD

  2. Center of Rehabilitation Medicine, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, 610041, China

    Yu Zheng MD & Chengqi He MD

  3. Institute for Disaster Management and Reconstruction, Sichuan University-The Hong Kong Polytechnic University, Huanghe Middle Road, Chengdu, 610041, China

    Yu Zheng MD & Chengqi He MD

  4. Department of Rehabilitation Medicine, Wuxi Rehabilitation Hospital, 100 Beitang Street, Wuxi, 214000, China

    Yu Zheng MD, Yan Yang MA, Ning Sun BSc, Tao Wang BSc, Huabo Li BSc & Lijie Zhang BSc

  5. The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    Yini Dang PhD, MD

Authors
  1. Yu Zheng MD
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  2. Yini Dang PhD, MD
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  3. Yan Yang MA
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  4. Ning Sun BSc
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  5. Tao Wang BSc
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  6. Huabo Li BSc
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  7. Lijie Zhang BSc
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  8. Chengqi He MD
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  9. M. S. Wong PhD
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Corresponding author

Correspondence to M. S. Wong PhD.

Additional information

This work was supported by the Wuxi Science and Technology Program (WSTP), China (grant number: ZD201408). The WSTP had no further role in study design; collection, analysis, and interpretation of data; writing of the report; or the decision to submit the paper for publication.

Author disclosures: None.

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Zheng, Y., Dang, Y., Yang, Y. et al. A Case-Control Study of Body Composition, Prevalence, and Curve Severity of the Patients With Adolescent Idiopathic Scoliosis in the East Part of China. Spine Deform 5, 374–380 (2017). https://doi.org/10.1016/j.jspd.2017.04.002

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  • DOI: https://doi.org/10.1016/j.jspd.2017.04.002

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