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Association of Two Polymorphisms in the Peroxisome Proliferator-Activated Receptor-γ Gene With Adenomyosis, Endometriosis, and Leiomyomata in Japanese Women

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Abstract

Objective

The peroxisome proliferator–activated receptor-γ (PPAR-γ) is a nuclear hormone receptor that plays an important role in many diseases. This study investigated whether two polymorphisms (Pro12Ala in exon B and C161T in exon 6) of the PPAR-γ2 gene are related to adenomyosis, endometriosis, or leiomyomata.

Methods

A total of 390 patients with adenomyosis, endometriosis, and/or leiomyomata were classified into four groups: 103 patients with adenomyosis (21 adenomyosis only and 82 adenomyosis with endometriosis and/or leiomyomata), 95 patients with endometriosis only, 100 patients with leiomyomata only, and 92 patients with endometriosis and leiomyomata.

Results

There was no association between distribution of genotype or allele frequencies for the PPAR-γ Pro12Ala polymorphism and the presence of adenomyosis, endometriosis, and/or leiomyomata. However, compared with results for controls, the PPAR-γ 161CC genotype and 161C allele frequencies were significantly increased in patients with adenomyosis (genotype: X2 = 8. 185, corrected P value [Pc] =. 0169; allele: X2 = 8. 331, Pc =. 0155) and inpatients with endometriosis (genotype: X2 = 6. 748, Pc =. 0375; allele: X2 = 6. 413, Pc =. 0453).

Conclusion

The results suggest that the PPAR-γ 161CC genotype could be a genetic risk factor for adenomyosis and endometriosis, whereas the Pro12Ala polymorphism was not associated with these estrogen-dependent benign uterine diseases in a fapanese population.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan

    Miyo Kiyomizu MD, Jo Kitawaki MD, PhD, Hiroshi Obayashi PhD, Mitsuhiro Ohta PhD, Hisato Koshiba MD, PhD, Hiroaki Ishihara MD, PhD & Hideo Honjo MD, PhD

  2. Department of Clinical Research, Institute of Bio-Response Informatics, Kyoto, Japan

    Miyo Kiyomizu MD, Jo Kitawaki MD, PhD, Hiroshi Obayashi PhD, Mitsuhiro Ohta PhD, Hisato Koshiba MD, PhD, Hiroaki Ishihara MD, PhD & Hideo Honjo MD, PhD

  3. Department of Medical Biochemistry, Kobe Pharmaceutical University, Kobe, Japan

    Miyo Kiyomizu MD, Jo Kitawaki MD, PhD, Hiroshi Obayashi PhD, Mitsuhiro Ohta PhD, Hisato Koshiba MD, PhD, Hiroaki Ishihara MD, PhD & Hideo Honjo MD, PhD

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  1. Miyo Kiyomizu MD
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  2. Jo Kitawaki MD, PhD
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  3. Hiroshi Obayashi PhD
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  4. Mitsuhiro Ohta PhD
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  5. Hisato Koshiba MD, PhD
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  6. Hiroaki Ishihara MD, PhD
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Correspondence to Jo Kitawaki MD, PhD.

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Kiyomizu, M., Kitawaki, J., Obayashi, H. et al. Association of Two Polymorphisms in the Peroxisome Proliferator-Activated Receptor-γ Gene With Adenomyosis, Endometriosis, and Leiomyomata in Japanese Women. Reprod. Sci. 13, 372–377 (2006). https://doi.org/10.1016/j.jsgi.2006.03.005

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  • DOI: https://doi.org/10.1016/j.jsgi.2006.03.005

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