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Matrix Metalloproteinase-1 and -9 Promoter Polymorphisms Are Not Associated With an Increased Risk of Uterine Leiomyomas in a Japanese Population

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Abstract

Objective

Matrix metalloproteinases (MMPs) play an important role in modeling and remodeling the extracellular matrix in leiomyomas. Hence, we investigated whether associations exist between leiomyomas and promoter polymorphisms in the MMP-i and MMP-9 genes in a Japanese population.

Methods

We compared the distribution of polymorphisms in the promoter regions of MMP-1 (− 1607 1G/2G) and MMP-9 (− 1562 C/T) in 267 leiomyoma patients and 184 control patients using polymerase chain reaction—fragment-length polymorphism (PCR-RFLP) analysis.

Results

The allele frequencies of the MMP-1 —1607 2G and MMP-9 −1562 T polymorphisms were 74.6% and 18.6% in leiomyoma patients, and 71.3% and 18.6Vo in control patients, respectively. No significant differences in allele frequencies or genotype distributions were found between leiomyoma and control patients. Moreover, no associations were found between MMP-1 and MMP-9 genotypes and leiomyoma size or a family history of the condition.

Conclusion

These findings suggest that MMP-1 and MMP-9 promoter polymorphisms are unlikely to be associated with an increased risk of uterine leiomyomas in Japanese women.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017, Japan

    Naoya Takemura MD, Shigeki Yoshida MD, PhD, Stephen Kennedy MRCOG, Masashi Deguchi MD, PhD, Noriyuki Ohara MD, PhD & Takeshi Maruo MD, PhD

  2. Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK

    Naoya Takemura MD, Shigeki Yoshida MD, PhD, Stephen Kennedy MRCOG, Masashi Deguchi MD, PhD, Noriyuki Ohara MD, PhD & Takeshi Maruo MD, PhD

Authors
  1. Naoya Takemura MD
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  2. Shigeki Yoshida MD, PhD
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  3. Stephen Kennedy MRCOG
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  4. Masashi Deguchi MD, PhD
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  5. Noriyuki Ohara MD, PhD
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  6. Takeshi Maruo MD, PhD
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Corresponding author

Correspondence to Takeshi Maruo MD, PhD.

Additional information

Supported by the Anglia and Oxford Regional Health Authority Research and Development Programme, a Grant-in-Aid for Scientific Research 16024212 from the Japanese Ministry of Education, Science and Culture.

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Takemura, N., Yoshida, S., Kennedy, S. et al. Matrix Metalloproteinase-1 and -9 Promoter Polymorphisms Are Not Associated With an Increased Risk of Uterine Leiomyomas in a Japanese Population. Reprod. Sci. 13, 232–236 (2006). https://doi.org/10.1016/j.jsgi.2006.02.004

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  • DOI: https://doi.org/10.1016/j.jsgi.2006.02.004

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