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Association Study of Endometriosis and Intercellular Adhesion Molecule-1 (ICAM-1) Gene Polymorphisms in a Japanese Population

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Abstract

Objective

Endometriosis is an immune-related, chronic inflammatory disease with polygenic predisposition. Cell adhesion molecules are expressed in endometriotic lesions, and in cells and tissues that are involved in the development and progression of the disease. In this study, we investigated the possible association between endometriosis and the G241R and K469E polymorphisms in the intercellular adhesion molecule-1 (ICAM-l) gene in a fapanese population.

Methods

We compared the distribution of the G241R and K469E polymorphisms in the ICAM-l gene in 126 endometriosis patients and 172 controls using polymerase chain reaction—restriction fragment length polymorphism (PCR-RFLP) analysis in a fapanese population.

Results

There were no significant differences between the cases and controls in the allele frequencies or genotype distributions of either the G241R or K469E polymorphisms in the ICAM-l gene. The endometriosis patients were divided into a subgroup of women with severe disease only. However, no significant differences were observed in the allele frequencies and genotype distributions of the ICAM-1 K469E polymorphisms between this subgroup and the controls. In contrast, only one in 169 controls was heterozygous (G/A genotype), and the A allele in the G2 41R polymorphism was not found in any of the 126 endometriosis patients.

Conclusion

Our findings suggest that the G241R and K469E polymorphisms in the ICAM-1 gene are unlikely to be associated with an increased risk of endometriosis in the fapanese population.

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References

  1. Sampson JA. Peritoneal endometriosis due to menstrual dissem-ination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol 1927;14:422–9.

    Article  Google Scholar 

  2. Nisolle M, Donnez J. Peritoneal endometriosis, ovarian endo-metriosis, and adenomyotic nodules of the rectovaginal septum are three different entities. Fertil Steril 1997;68:585–96.

    Article  CAS  PubMed  Google Scholar 

  3. Oosterlynck DJ, Cornillie FJ, Waer M, Vandeputte M, Koninckx PR. Women with endometriosis show a defect in natural killer activity resulting in a decreased cytotoxicity to autologous endometrium. Fertil Steril 1991;56:45–51.

    Article  CAS  PubMed  Google Scholar 

  4. Vigano P, Vercellini P, Di Blasio AM, Colombo A, Candiani GB, Vignali M. Deficient antiendometrium lymphocytemediated cytotoxicity in patients with endometriosis. Fertil Steril 1991;56:894–9.

    Article  CAS  PubMed  Google Scholar 

  5. Dmowski WP, Gebel HM, Braun DP. The role of cell-mediated immunity in pathogenesis of endometriosis. Acta Obstet Gynecol Scand 1994;159:7–14.

    CAS  Google Scholar 

  6. Simpson JL, Elias S, Malinak LR, Buttram VC. Heritable aspects of endometriosis. I. Genetic studies. Am J Obstet Gynecol 1980;137:327–31.

    Article  CAS  PubMed  Google Scholar 

  7. Coxhead D, Thomas EJ. Familial inheritance of endometriosis in a British population. A case control study. T Obstet Gynaecol 1993;13:42–4.

    Article  Google Scholar 

  8. Moen MH, Magnus P. The familial risk of endometriosis. Acta Obstet Gynecol Scand 1993;72:560–4.

    Article  CAS  PubMed  Google Scholar 

  9. Moen MH. Endometriosis in monozygotic twins. Acta Obstet Gynecol Scand 1994;73:59–62.

    Article  CAS  PubMed  Google Scholar 

  10. Haldfield RM, Maedon HJ, Barlow DH, Kennedy SH. Endo-metriosis in monozygotic twins. Fertil Steril 1997;68:941–2.

    Article  Google Scholar 

  11. Haldfield RM, Yudkin PL, Coe CL, et al. Risk factors for endometriosis in the rhesus monkey (Macaca mulatta): A casecontrol study. Hum Reprod Updates 1997;3:109–15.

    Article  Google Scholar 

  12. Rothlein R, Dustin ML, Marlin SD, Springer TA. A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J Immunol 1986;137:1270–4.

    CAS  PubMed  Google Scholar 

  13. Marlin SD, Springer TA. Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte functionassociated antigen-1. Cell 1987;51:813–9.

    Article  CAS  PubMed  Google Scholar 

  14. Diamond MS, Staunton DE, de Fougerolles AR, et al. ICAM-1 (CD54): A counter-receptor for Mac-1 (CDllb/CD18). J Cell Biol 1990;111:3129–39.

    Article  CAS  PubMed  Google Scholar 

  15. Hayflick JS, Kilgannon P, Gallatin WM. The intercellular adhesion molecule (ICAM) family of proteins. Immunol Res 1998;17:313–27.

    Article  CAS  PubMed  Google Scholar 

  16. Somigliana E, Vigano P, Gaffuri B, Guarneri D, Busacca M, Vignali M. Human endometrial stromal cells as a source of soluble intercellular adhesion molecule (ICAM)-l molecules. Hum Reprod 1996;11:1190–4.

    Article  CAS  PubMed  Google Scholar 

  17. Wu MH, Yang BC, Hsu CC, Lee YC, Huang KE. The expression of soluble intercellular adhesion molecule-1 in endometriosis. Fertil Steril 1998;70:1139–42.

    Article  CAS  PubMed  Google Scholar 

  18. Vigano P, Gaffuri B, Somigliana E, Busacca M, Di Blassio AM, Vignali M. Expression of intercellular adhesion molecule (ICAM)-l mRNA and protein is enhanced in endometriosis versus endometrial stromal cells in culture. Mol Hum Reprod 1998;4:1150–6.

    Article  CAS  PubMed  Google Scholar 

  19. De Placido G, Alviggi C, Di Palma G, et al. Serum concentration of soluble human leukocyte class I antigens and of the soluble intercellular adhesion molecule-1 in endometriosis: Relationship with stage and non-pigmented peritoneal lesions. Hum Reprod 1998;13:3206–10.

    Article  PubMed  Google Scholar 

  20. Vora DK, Rosenbloom CL, Beaudet AL, Cottingham RW. Polymorphisms and linkage analysis for ICAM-1 and the selectin gene cluster. Genomics 1994;21:473–7.

    Article  CAS  PubMed  Google Scholar 

  21. Verity DH, Vaughan RW, Kondeatis E, et al. Intercellular ad-hesion molecule-1 gene polymorphisms in Behcet’s disease. Eur J Immunogenet 2000;27:73–6.

    Article  CAS  PubMed  Google Scholar 

  22. Mycko MP, Kwinkowski M, Troncznska E, Szymanska B, Selmaj KW. Multiple sclerosis: The increased frequency of the ICAM-1 exon 6 gene point mutation genetic type K469. Ann Neurol 1998;44:70–5.

    Article  CAS  PubMed  Google Scholar 

  23. Yang H, Voca DK, Targan SR, Toyoda H, Beaudet AL, Rotter JI. Intercellular adhesion molecule 1 gene associations with im-munologic subsets of inflammatory bowel disease. Gastroenter-ology 1995;109:440–8.

    Article  CAS  Google Scholar 

  24. Vigano P, Infantino M, Lattuada D, et al. Intercellular adhesion molecule-1 (ICAM-1) gene polymorphisms in endometriosis. Mol Hum Reprod 2003;9:47–52.

    Article  CAS  PubMed  Google Scholar 

  25. The American Fertility Society. Revised American Fertility So-ciety classification of endometriosis. Fertil Steril 1985;43:351–2.

    Article  Google Scholar 

  26. Amoli MM, Shelley E, Mattey DL, et al. Lack of association between intercellular adhesion molecule-1 gene polymorphisms and giant cell arteritis. J Rheumatol 2001;28:1600–4.

    CAS  PubMed  Google Scholar 

  27. Kristiansen OP, Nolsoe RL, Holst H, et al. The intercellular adhesion molecule-1 K469E polymorphism in type 1 diabetes. Immunogenetics 2000;52:107–11.

    Article  CAS  PubMed  Google Scholar 

  28. Zondervan KT, Cardon LR, Kennedy SH. What makes a good case-control study? Design issues for complex traits such as endometriosis. Hum Reprod 2002;17:1415–23.

    Article  PubMed  Google Scholar 

  29. Braun C, Zahn R, Martin K, Albert E, Folwaczny C. Polymor-phisms of the ICAM-1 gene are associated with inflammatory bowel disease, regardless of the p-ANCA status. Clin Immunol 2001;101:357–60.

    Article  CAS  PubMed  Google Scholar 

  30. Kim EH, Mok JW, Bang D, Lee ES, Lee S, Park K. Intercellular adhesion molecule-1 polymorphisms in Korean patients with Behcet’s disease. J Korean Med Sei 2003;18:415–8.

    Article  CAS  Google Scholar 

  31. Matsuzawa J, Sugimura K, Matsuda Y, et al. Association between K469E allele of intercellular adhesion molecule 1 gene and in-flammatory bowel disease in a Japanese population. Gut 2003;52:75–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Eskenazi B, Warner ML. Epidemiology of endometriosis. Obstet Gynecol Clin North Am 1997;24:235–58.

    Article  CAS  PubMed  Google Scholar 

  33. Izumiya C, Maeda N, Kusume T, et al. Coordinated but depressed expression of human leukocyte antigen-DR, intercellular adhesion molecule-1, and CD 14 on peritoneal macrophages in women with pelvic endometriosis. Fertil Steril 2003;80:768–75.

    Article  PubMed  Google Scholar 

  34. Collins T, Williams A, Johnston GI, et al. Structure and chro-mosomal location of the gene for endothelial-leukocyte molecule 1. J Biol Chem 1991;266:2466–73.

    CAS  PubMed  Google Scholar 

  35. Diamond MS, Staunton DE, Marlin SD, Springer TA. Binding of the integrin Mac-1 (CD1 lb/CD 18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation. Cell 1991;65:961–71.

    Article  CAS  PubMed  Google Scholar 

  36. Salvarani C, Casali B, Boiardi L, et al. Intercellular adhesion molecule 1 gene polymorphisms in polymyalgia rheumatica/ giant cell arteritis: Association with disease risk and severity. J Rheumatol 2000;27:1215–21.

    CAS  PubMed  Google Scholar 

  37. Boiardi L, Salvarani C, Casali B, et al. Intercellular adhesion molecule-1 gene polymorphisms in Behcet’s disease. J Rheuma-tol 2001;28:1283–7.

    CAS  Google Scholar 

  38. Staunton DE, Dustin ML, Erickson HP, Springer TA. The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus. Cell 1990;61:243–54.

    Article  CAS  PubMed  Google Scholar 

  39. Joling P, Boom S, Johnson J, et al. Domain 5 of the intercellular adhesion molecule-1 (ICAM-1) is involved in adhesion of B-cells and follicular dendritic cells. Adv Exp Med Biol 1994;355:131–5.

    Article  CAS  PubMed  Google Scholar 

  40. Kamiuchi K, Hasegawa G, Obayashi H, et al. Intercellular ad-hesion molecule-1 (ICAM-1) polymorphism is associated with diabetic retinopathy in type 2 diabetes mellitus. Diabet Med 2002;19:371–6.

    Article  CAS  PubMed  Google Scholar 

  41. Kitawaki J, Obayashi H, Ishihara H, et al. Oestrogen receptoralpha gene polymorphism is associated with endometriosis, adenomyosis and leiomyomata. Hum Reprod 2001;46:342–6.

    Google Scholar 

  42. Kado N, Kitawaki J, Obayashi H, et al. Association of the CYP17 gene and CYP19 gene polymorphisms with risk of endometriosis in Japanese women. Hum Reprod 2002;17:897–902.

    Article  CAS  PubMed  Google Scholar 

  43. Asghar T, Yoshida S, Kennedy S, et al. The tumor necrosis factor-alpha promoter —1031C polymorphism is associated with decreased risk of endometriosis in a Japanese population. Hum Reprod 2004;19:2509–14.

    Article  CAS  PubMed  Google Scholar 

  44. Hadfield R, Mardon H, Barlow D, Kennedy S. Delay in the diagnosis of endometriosis: A survey of women from the USA and UK. Hum Reprod 1996;11:878–80.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho Chuo-ku, Kobe, Japan

    Masako Yamashita MD, Shigeki Yoshida PhD, Stephen Kennedy MRCOG, Noriyuki Ohara PhD, Satoru Motoyama PhD & Takeshi Maruo PhD

  2. Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK

    Masako Yamashita MD, Shigeki Yoshida PhD, Stephen Kennedy MRCOG, Noriyuki Ohara PhD, Satoru Motoyama PhD & Takeshi Maruo PhD

Authors
  1. Masako Yamashita MD
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  2. Shigeki Yoshida PhD
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  3. Stephen Kennedy MRCOG
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  4. Noriyuki Ohara PhD
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  6. Takeshi Maruo PhD
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Corresponding author

Correspondence to Takeshi Maruo PhD.

Additional information

This work was supported by a Grant-in-Aid for Scientific Research 05390506 from the Japanese Ministry of Education, Science and Culture and the Japan Association of Obstetricians and Gynecologists Ogyaa-Donation Foundation (JODF).

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Yamashita, M., Yoshida, S., Kennedy, S. et al. Association Study of Endometriosis and Intercellular Adhesion Molecule-1 (ICAM-1) Gene Polymorphisms in a Japanese Population. Reprod. Sci. 12, 267–271 (2005). https://doi.org/10.1016/j.jsgi.2005.03.002

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  • DOI: https://doi.org/10.1016/j.jsgi.2005.03.002

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