Skip to main content

Advertisement

SpringerLink
Log in

No Association of Endometriosis With Glutathione S-Transferase M1 and T1 Null Mutations in a Japanese Population

  • Original Articles
  • Published:
The Journal of the Society for Gynecologic Investigation: JSGI Aims and scope Submit manuscript

Abstract

Objective

Endometriosis is inherited as a complex trait, which means that multiple susceptibility genes interact with each other and with environmental factors to produce the phenotype. We investigated the frequency of glutathione S-transferase M1 and T1 (GSTM1 and GSTT1) null mutations in women with endometriosis in a Japanese population.

Methods

One hundred fourteen unrelated women with endometriosis were enrolled. Samples of umbilical cord blood obtained from 179 female newborn infants were used as population controls. Genomic DNA isolated from endometriosis patients and controls were subjected to multiple polymerase chain reactions to determine the GSTM1 and GSTT1 genotypes.

Results

There were no significant differences in the frequencies of the GSTM1 (P =.83, odds ratio 0.95) and GSTT1 (P =.24, odds ratio 0.75) null mutations between endometriosis patients and controls. The endometriosis group was divided into a subgroup of stage IV disease only, but no statistically significant differences were observed in the frequency of the GSTM1 null mutation (P =.88, odds ratio 0.96, 95% confidence interval 0.57-1.63) and the GSTT1 null mutation (P =.33, odds ratio 0.77, 95% confidence interval 0.45-1.30) between any of these groups and the controls.

Conclusion

These findings suggest that the GSTM1 and GSTT1 null mutations are not likely to be associated with an increased risk of endometriosis in a Japanese population.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Moen MH. Endometriosis in monozygotic twins. Acta Obstet Gynecol Scand 1994;73:59–62.

    Article  CAS  Google Scholar 

  2. Hadfield RM, Mardon HJ, Barlow DH, Kennedy SH. Endometriosis in monozygotic twins. Fertil Steril 1997;68:941–2.

    Article  CAS  Google Scholar 

  3. Simpson JL, Elias S, Malinak LR, Buttram VC Jr. Heritable aspects of endometriosis. I. Genetic studies. Am J Obstet Gynecol 1980;137:327–31.

    Article  CAS  Google Scholar 

  4. Moen MH, Magnus P. The familial risk of endometriosis. Acta Obstet Gynecol Scand 1993;72:560–4.

    Article  CAS  Google Scholar 

  5. Kennedy S, Hadfield R, Westbrook C, Weeks DE, Barlow D, Golding S. Magnetic resonance imaging to assess familial risk in relatives of women with endometriosis. Lancet 1998;352:1440–1.

    Article  CAS  Google Scholar 

  6. Kennedy S. Is there a genetic basis to endometriosis? Semin Reprod Endocrinol 1997;15:309–18.

    Article  CAS  Google Scholar 

  7. Rier SE, Martin DC, Bowman RE, Dmowski WP, Becker JL. Endometriosis in rhesus monkeys (Macaca mulatta) following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundam Appl Toxicol 1993;21:433–41.

    Article  CAS  Google Scholar 

  8. Nakago S, Hadfield RM, Zondervan KT, et al. Association between endometriosis and N-acetyl transferase 2 polymorphisms in a UK population. Mol Hum Reprod 2001;7:1079–83.

    Article  CAS  Google Scholar 

  9. Board P, Coggan M, Johnston P, Ross V, Suzuki T, Webb G. Genetic heterogeneity of the human glutathione transferases: A complex of gene families. Pharmacol Ther 1990;48:357–69.

    Article  CAS  Google Scholar 

  10. Seidegard J, Pero RW, Miller DG, Beattie EJ. A glutathione transferase in human leukocytes as a marker for the susceptibility to lung cancer. Carcinogenesis 1986;7:751–3.

    Article  CAS  Google Scholar 

  11. Bell DA, Taylor JA, Paulson DF, Robertson CN, Mohler JL, Lucier GW. Genetic risk and carcinogen exposure: A common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer. J Natl Cancer Inst 1993;85:1159–64.

    Article  CAS  Google Scholar 

  12. Baranova H, Perriot J, Albuisson E, et al. Peculiarities of the GSTM1 0/0 genotype in French heavy smokers with various types of chronic bronchitis. Hum Genet 1997;99:822–6.

    Article  CAS  Google Scholar 

  13. Hallier E, Schroder KR, Asmuth K, Dommermuth A, Aust B, Goergens HW. Metabolism of dichloromethane (methylene chloride) to formaldehyde in human erythrocytes: Influence of polymorphism of glutathione transferase theta (GST T1-1). Arch Toxicol 1994;68:423–7.

    Article  CAS  Google Scholar 

  14. Baranov VS, Ivaschenko T, Bakay B, et al. Proportion of the GSTM1 0/0 genotype in some Slavic populations and its correlation with cystic fibrosis and some multifactorial disease. Hum Genet 1996;97:516–20.

    Article  CAS  Google Scholar 

  15. Baranova H, Bothorishvilli R, Canis M, et al. Glutathione S-transferase M1 gene polymorphism and susceptibility to endometriosis in a French population. Mol Hum Reprod 1997;3:775–80.

    Article  CAS  Google Scholar 

  16. Baranova H, Canis M, Ivaschenko T, et al. Possible involvement of arylamine N-acetyltransferase 2, glutathione S-transferases Ml and Tl genes in the development of endometriosis. Mol Hum Reprod 1999;5:636–41.

    Article  CAS  Google Scholar 

  17. Hadfield RM, Manek S, Weeks DE, et al. Linkage and association studies of the relationship between endometriosis and genes encoding the detoxification enzymes GSTM1, GSTT1 and CYP1A1. Mol Hum Reprod 2001;7:1073–8.

    Article  CAS  Google Scholar 

  18. The American Fertility Society. Revised American fertility society classification of endometriosis. Fertil Steril 1985;43:351–2.

    Article  Google Scholar 

  19. Arand M, Muhlbauer R, Hengstler J, et al. A multiplex polymerase chain fraction protocol for the simultaneous analysis of the glutathione S-transferase GSTM1 and GSTT1 polymorphisms. Anal Biochem 1996;236:184–6.

    Article  CAS  Google Scholar 

  20. Kihara M, Kihara M, Noda K. Risk of smoking for squamous and small cell carcinoma of the lung modulated by combinations of CYP1A1 and GSTM1 gene polymorphisms in a Japanese population. Carcinogenesis 1995;16:2331–6.

    Article  CAS  Google Scholar 

  21. Katoh T, Nagata N, Kuroda Y, et al. Glutathione S-transferase Ml (GSTM1) and T1 (GSTT1) genetic polymorphism and susceptibility to gastric and colorectal adenocarcinoma. Carcinogenesis 1996;17:1855–9.

    Article  CAS  Google Scholar 

  22. Morinobu A, Kanagawa S, Koshiba M, Sugai S, Kumagai S. Association of glutathione S-transferase M1 homozygous null genotype with susceptibility to Sjogren’s syndrome in Japanese individuals. Arthritis Rheum 1999;42:2612–5.

    Article  CAS  Google Scholar 

  23. Zondervan KT, Cardon LR, Kennedy SH. What makes a good case-control study? Design issues for complex traits such as endometriosis. Hum Reprod 2002;17:1415–23.

    Article  Google Scholar 

  24. Nebert DW, Gonzalez FJ. P450 genes: Structure, evolution and regulation. Annu Rev Biochem 1987;56:945–93.

    Article  CAS  Google Scholar 

  25. Safe SH. Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Pharmacol Ther 1995;67:247–81.

    Article  CAS  Google Scholar 

  26. Murata M, Watanabe M, Yamanaka M, et al. Genetic polymorphisms in cytochrome P450 (CYP) 1A1, CYP1A2, Cyp2E1, glutathione S-transferase (GST) M1 and GSTT1 and susceptibility to prostate cancer in the Japanese population. Cancer Lett 2001;165:171–7.

    Article  CAS  Google Scholar 

  27. Kitawaki J, Obayashi H, Ishihara H, et al. Oestrogen receptor-alpha gene polymorphism is associated with endometriosis, adenomyosis and leiomyomata. Hum Reprod 2001;16:51–5.

    Article  CAS  Google Scholar 

  28. Watanabe T, Imoto I, Kosugi Y, et al. Human arylhydrocarbon receptor repressor (AHRR) gene: Genomic structure and analysis of polymorphism in endometriosis. J Hum Genet 2001;46:342–6.

    Article  CAS  Google Scholar 

  29. Hadfield R, Mardon H, Barlow D, Kennedy S. Delay in the diagnosis of endometriosis: A survey of women from the USA and UK. Hum Reprod 1996;11:878–80.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho Chuo-ku, Kobe, Japan

    Mayumi Morizane MD, Shigeki Yoshida PhD, Satoshi Nakago PhD, Shinya Hamana PhD, Takeshi Maruo PhD & Stephen Kennedy PhD

  2. Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK

    Mayumi Morizane MD, Shigeki Yoshida PhD, Satoshi Nakago PhD, Shinya Hamana PhD, Takeshi Maruo PhD & Stephen Kennedy PhD

Authors
  1. Mayumi Morizane MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shigeki Yoshida PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Satoshi Nakago PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shinya Hamana PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Takeshi Maruo PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Stephen Kennedy PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Takeshi Maruo PhD.

Additional information

This work was supported by the Anglia and Oxford Regional Health Authority Research and Development Programme, a Grant-in-Aid for Scientific Research 12877263 from the Japanese Ministry of Education, Science and Culture and the Japan Association of Obstetricians and Gynecologists Ogyaa-Donation Foundation (JODF).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Morizane, M., Yoshida, S., Nakago, S. et al. No Association of Endometriosis With Glutathione S-Transferase M1 and T1 Null Mutations in a Japanese Population. Reprod. Sci. 11, 118–121 (2004). https://doi.org/10.1016/j.jsgi.2003.07.009

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1016/j.jsgi.2003.07.009

Key words

Search

Navigation