Abstract
The main objective of this study was to identify the risk factors of dyslipidemia and measure its impact on patients’ quality of life (QOL). Secondary objectives were to determine the percentage of dyslipidemia and assess the predictive factors affecting patients’ QOL. A cross-sectional study was conducted in a sample of Lebanese population. A standardized questionnaire was developed to assess the QOL using the Short form-36 (SF-36) score. A total of 452 individuals were interviewed, of which 59.5% were females. The mean age was 43.3 ± 15.6 years, and 24.8% had dyslipidemia. The results show a lower overall QOL score among dyslipidemic patients compared with controls (57.9% and 76.5%, respectively; p < 0.001). Waterpipe smoking [adjusted odds ratio (ORa) =4.113, 95% confidence interval (CI): 1.696–9.971, p = 0.002], hypertension (ORa = 3.597, 95% CI: 1.818–7.116, p < 0.001), diabetes (ORa = 3.441, 95% CI: 1.587–7.462, p = 0.002), cigarette smoking (ORa = 2.966, 95% CI: 1.516–5.804, p = 0.001), and passive smoking (ORa = 2.716, 95% CI: 1.376–5.358, p = 0.004) were significantly associated with dyslipidemia in individuals older than 30 years. A higher overall QOL score (p = 0.013) was observed in patients treated with statins in comparison with other lipid-lowering medications. In addition to clinical and economical consequences, dyslipidemia may have a significant impact on patients’ QOL. Further research is needed to confirm the impact of treatment on dyslipidemic patients’ QOL in order to maximize the overall benefits of therapy.
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References
European Association for Cardiovascular Prevention & Rehabilitation, Reiner Z, Catapano AL, De Backer G, Graham I, Taskinen MR, et al. ESC/EAS guidelines for the management of dyslipidaemias: the task force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur Heart J 2011;32:1769–818.
Roche ObEpi. Enquête épidémiologique nationale sur le surpoids et l’obésité. France: Une enquête inserm/kantar health/roche; 2012. Available at: <http://www.roche.fr/content/dam/corporate/roche_fr/doc/obepi_2012.pdf> [Accessed on April 2014].
Ford E, Mokdad A, Giles W, Mensah G. Serum total cholesterol concentrations and awareness, treatment and control of hypercholesterolemia among US adul. Findings from the National Health and Nutrition Examination Survey, 1999 to 2000. Circulation 2003;107:2185–9.
Xu T, Zhang JT, Yang M, Zhang H. Dyslipidemia and outcome in patients with acute ischemic stroke. Biomed Environ Sci 2014;27:106–10.
Keil U, Kuulasmaa K. Who monica project: risk factors. Int J Epidemiol 1989; 18(3 (Suppl. 1)):S46–55.
Kannel WB, Castelli WP, Gordon T. Cholesterol in the prediction of atherosclerotic disease. New perspectives based on the Framingham study. Ann Intern Med 1979;90:85–91.
Law MR, Wald NJ, Thompson SG. By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease? BMJ 1994;308:367–72.
Al Sifri SN, Almahmeed W, Azar S, Okkeh O, Bramlage P, Jünger C, et al. Results of the Dyslipidemia International Study (DYSIS)—Middle East: clinical perspective on the prevalence and characteristics of lipid abnormalities in the setting of chronic statin treatment. PLoS One 2014;9: e84350.
Tabatabaei-Malazy O, Qorbani M, Samavat T, Sharifi F, Larijani B, Fakhrzadeh H. Prevalence of dyslipidemia in Iran: a systematic review and meta-analysis study. Int J Prev Med 2014;5:373–93.
Azar ST, Hantash HA, Jambart S, El-Zaheri MM, Rachoin R, Chalfoun A, et al. Factors influencing dyslipidemia in statin-treated patients in Lebanon and Jordan: results of the Dyslipidemia International Study. Vasc Health Risk Manag 2014;10:225–35.
Wang CJ, Li YQ, Wang L, Li LL, Guo YR, Zhang LY, et al. Development and evaluation of a simple and effective prediction approach for identifying those at high risk of dyslipidemia in rural adult residents. PLoS One 2012;7: e43834.
Lalonde L, O’Connor A, Joseph L, Grover SA. Health-related quality of life in cardiac patients with dyslipidemia and hypertension. Qual Life Res 2004;13:793–804.
Martinelli LM, Mizutani BM, Mutti A, D’elia MP, Coltro RS, Matsubara BB. Quality of life and its association with cardiovascular risk factors in a community health care program population. Clinics (Sao Paulo) 2008;63:783–8.
Fleck MP, Louzada S, Xavier M, Chachamovich E, Vieira G, Santos L, et al. Application of the Portuguese version of the instrument for the assessment of quality of life of the World Health Organization (WHOQOL-100). Rev Saude Publica 1999;33:198–205.
Lalonde L, Clarke AE, Joseph L, Mackenzie T, Grover SA. Health-related quality of life with coronary heart disease prevention and treatment. J Clin Epidemiol 2001;54:1011–8.
Theodorou M, Kaitelidou D, Galanis P, Middleton N, Theodorou P, Stafylas P, et al. Quality of Life measurement in patients with hypertension in Cyprus. Hellenic J Cardiol 2011;52:407–15.
Sabbah I, Drouby N, Sabbah S, Retel-Rude N, Mercier M. Quality of life in rural and urban populations in Lebanon using SF-36 health survey. Health Qual Life Outcomes 2003;1:30.
Ware Jr JE, Sherbourne CD. The MOS 36-Item Short-Form Health Survey (SF-36): I. conceptual framework and item selection. Med Care 1992;30:473.
Bounthavong M, Law AV. Identifying health-related quality of life (HRQL) domains for multiple chronic conditions (diabetes, hypertension and dyslipidemia): patient and provider perspectives. J Eval Clin Pract 2008;14:1002–11.
Zamotaev IN. Medico-social factors influencing the course of arterial hypertension and the quality of life. Klin Med (Mosk) 2012;90:25–31.
Trevisol DJ, Moreira LB, Fuchs FD, Fuchs SC. Health-related quality of life and awareness of hypertension. J Hypertens 2012;30:629.
Lee MH, So ES. Impact of hypertension-related comorbidity on health-related quality of life: a population-based survey in South Korea. Asia Pac J Public Health 2012;24:753–63.
Zyoud SH, Al-Jabi SW, Sweileh WM, Wildali AH, Saleem HM, Aysa HA, et al. Health-related quality of life associated with treatment adherence in patients with hypertension: a cross-sectional study. Int J Cardiol 2013;168:2981–3.
Jaber A. Effects of food supplements and physical activity on cardiovascular disease: a case control pilot study. Mémoire master 2 recherche, épidémiologie et biostatistique, Université Libanaise; 2012, p. 30.
Carvalho MA, Silva IB, Ramos SB, Coelho LF, Gonc¸alves ID, Figueiredo Neto JA. Quality of life of hypertensive patients and comparison of two instruments of HRQOL measure. Arq Bras Cardiol 2012;98:442–51.
Kolotkin RL, Meter K, Williams GR. Quality of life and obesity. Obes Rev 2001;2:219–29.
Kushner RF, Foster GD. Obesity and quality of life. Nutrition 2000;16:947–52.
Heikkinen H, Jallinoja P, Saarni SI, Patja K. The impact of smoking on health-related and overall quality of life: a general population survey in Finland. Nicotine Tob Res 2008;10:1199–207.
Zenger M, Hinz A, Petermann F, Brähler E, Stöbel-Richter Y. Health and quality of life within the context of unemployment and job worries. Psychother Psychosom Med Psychol 2013;63:129–37.
Aydenian H, Fadel MA, Baddoura R. Epidemiological study of hyperlipemia in a Lebanese population. Ann Biol Clin (Paris) 1999;57:697–703.
Ncep III. Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 2001;285:2486–97.
Bayram F, Kocer D, Gundogan K, Kaya A, Demir O, Coskun R, et al. Prevalence of dyslipidemia and associated risk factors in Turkish adults. J Clin Lipodol 2014;8:206–16.
Wang J, Zhang RY, Chen RP, Chen LS, Lin SD, Liang GX, et al. Prevalence and risk factors for dyslipidemia in diabetics with overweight or obesity. Zhong Yi Xue Za Zhi 2013;93:2851–6.
Ebrahimi H, Emamian MH, Hashemi H, Fotouhi A. Dyslipidemia and its risk factors among urban middle-aged Iranians: a population-based study. Diabetes Metab Syndr 2016;10:149–156.
Sun G-Z, Li Z, Guo L, Zhou Y, Yang HM, Sun YX. High prevalence of dyslipidemia and associated risk factors among rural Chinese adults. Lipids Health Dis 2014;13:189.
Erem C, Hacihasanoglu A, Deger O, Kocak M, Topbas M. Prevalence of dyslipidemia and associated risk factors among Turkish adults: Trabzon lipid study. Endocrine 2008;34:36–51.
Spilker B, Revicki DA. Taxonomy of quality of life. In: Spilker B, editor. Quality of life and pharmacoeconomics in clinical trials. Philadelphia: Lippincott-Raven Publishers; 1996. p. 25–31.
Hari Babu R, Nagaraju R, Prasad Kvsrg, Reddy S. Assessment of medication adherence and quality of life in hyperlipidemia patients. Int J Pharma Bio Sci 2012;1:388–93.
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Farhat, A., Al-Hajje, A., Rachidi, S. et al. Risk factors and quality of life of dyslipidemic patients in Lebanon: A cross-sectional study. J Epidemiol Glob Health 6, 315–323 (2016). https://doi.org/10.1016/j.jegh.2016.10.001
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DOI: https://doi.org/10.1016/j.jegh.2016.10.001